Frenolicin B

Discovery, producing organism and structure (1)

Frenolicin B and deoxyfrenolicin were isolated during the course of screening for antimycoplasmal antibiotics from the culture broth of the actinomycete strain AM-3867. The total synthesis of frenolicin B has been reported by many groups. The first total synthesis was reported by Kraus et al (2).

Physical data (Frenolicin B) (1)

Orange columns. C₁₈H₁₆O₆; mol wt 328.09. Sol. in MeOH.

Biological activity (1,3)

1) Antimicrobial activity (1)

2) Frenolicin B shows anticoccidial activity in vitro and a strong immunity against Eimeria tenella infection in chicks (3).

References

1. [145] Y. Iwai et al., J. Antibiot., 31, 959–965 (1978)
2. G. A. Kraus et al., J. Am. Chem. Soc., 115, 5859–5860 (1993)
3. [332] S. Ōmura et al., J. Antibiot., 38, 1447–1448 (1985)