Luminamicin

Discovery, producing organism and structure (1,2)

Luminamicin was isolated from a culture broth of the actinomycete strain OMR-59. It exhibits antibacterial activity against anaerobic bacteria, particularly Clostridium sp. (1,2). Luminamicin is identical to coloradocin, discovered by Abbott’s group to be an anti-anaerobe antibiotic. The structure of coloradocin was elucidated by Rasmussen et al (3).

Physical data

Colorless needles; C₃₂H₃₈O₁₂; mol wt 614.24. Sol. in MeOH, acetone, EtOAc. Insol. in H₂O, hexane.

Biological activity (1,2)

Antimicrobial activity (1,2).

References

1. [330] S. Ōmura et al., J. Antibiot., 38, 1322–1326 (1985)
2. [371] S. Taga et al., Kitasato Arch. Exp. Med., 60, 15–24 (1987)
3. R. Rasmussen et al., J. Antibiot., 40, 1383–1393 (1987).