Setamycin

Discovery, producing organism and structure (1-8)

Setamycin was isolated from a culture broth of the actinomycete strain KM-6054 and recognized to possess antimicrobial and nematocidal activity (1,2). Later, bafilomycin (3,4), a Golgi protein transfer inhibitor was found, and bafilomycin B1 was identified as being identical in structure to setamycin. The taxonomic study of the producing strain led us to establish a new genus of Kitasatospora setae (4–6).

Physical data

Yellow powder. C₄₄H₆₅NO₁₃; mol wt 815.45. Sol. in MeOH, EtOH, benzene. Insol. in H₂O, hexane.

Biological activity (1,2)

1) Antimicrobial spectrum (1)

2) Setamycin has nematocidal activity (pine wood nematode, Bursaphelenchus lignicolus) with an IC₅₀ value of 10 µg/ml²).

References

1. [216] S. Ōmura et al., J. Antibiot., 34, 1253–1256 (1981)
2. [383] K. Otoguro et al., J. Antibiot., 41, 250–252 (1988)
3. G. Werner et al., J. Antibiot., 37, 110–117 (1984)
4. [224] S. Ōmura et al., J. Antibiot., 34, 1633–1634 (1981)
5. [245] S. Ōmura et al., J. Antibiot., 35, 1013–1019 (1982)
6. [721] Y. Takahashi et al., Zent. bl. Bacteriol. 289, 263-284 (1999)
7. [721] G. Michael et al., J. Antibiot., 50, 1073–1077 (1997)
8. E. Ohta et al., Tetrahedron Lett., 42, 4179–4181 (2001)