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Discovery, chemistry, and chemical biology of microbial products [abstract]
Splendid gifts: Fifth edition
Splendid gifts from microorganisms - the achievements of Satoshi Omura and collaborators. [how to order]
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Publications: 1970-1974
30) S. Ōmura, M. Katagiri, A. Nakagawa, H. Yamada, I. Umezawa, K. Komiyama, and T. Hata: Studies on the chemical structure and some biological properties of leucomycins (kitasamycins) and their related macrolide antibiotics (Review article). In "Progress in Antimicrobial and Anticancer Chemotherapy-Proceedings of the 6th International Congress of Chemotherapy" 1043-1049, University of Tokyo Press (1970).
31) M. Hiramatsu, A. Furusaki, T. Noda, K. Naya, Y. Tomiie, I. Nitta, T. Watanabe, T. Take, J. Abe, S. Ōmura and T. Hata: The crystal and molecular structure of demycarosylleucomycin A3 hydro-bromide. Bull. Chem. Soc. Jpn., 43, 1966-1975 (1970).
32) S. Ito, T. Matsuya, S. Ōmura, M. Otani, A. Nakagawa, H. Takeshima, Y. Iwai, M. Ohtani, and T. Hata: A new antibiotic, kinamycin. J. Antibiot., 23, 315-317 (1970).
33) S. Ōmura, A. Nakagawa, M. Katagiri, T. Hata, M. Hiramatsu, T. Kimura, and K. Naya: Chemistry of leucomycins. VIII. Absolute configuration of leucomycin and isoleucomycin. Chem. Pharm. Bull., 18, 1501-1508 (1970).
34) S. Ōmura, Y. Hironaka, and T. Hata: Chemistry of leucomycins. IX. Identification of leucomycin A3 with josamycin. J. Antibiot., 23, 511-513 (1970).
35) S. Ōmura: Macrolide antibiotics. (Review article). Kagaku to Seibutsu (Chemistry and Biology), 8, 139-150 (1970).
36) S. Ōmura: Studies on macrolide antibiotics (Review article). In "Proceedings of Symposium on Antibiotics of The 14th Annual Meeting of Kanto Branch, Pharmaceutical Soc. Jpn." 13-20 (1970).
37) T. Hata and S. Ōmura: Advances in antibiotics. Chemistry and Chemical Industry, 21, 347-354 (1968).
38) S. Ōmura, M. Otani, M. Ohtani, and T. Hata: I-2743-C, new antimycin analogue from a Kitasatoa sp. nov. Kitasato Arch. Exp. Med., 43, 29-33 (1970).
39) Y. Iwai, S. Ōmura, and T. Hata: Studies on the determination of glycerol in fermented broth of antibiotic-production by Streptomyces sp. J. Ferm. Technol., 49 842-846 (1971).
40) T. Hata, S. Ōmura, Y. Iwai, A. Nakagawa, M. Otani, S. Ito, and T. Matsuya: A new antibiotic, kinamycin: Fermentation, isolation, purification and properties. J. Antibiot., 24, 353-359 (1971).
41) M. Onda, Y. Konda, S. Ōmura, and T. Hata: Structure of carzinophilin. II. A new amino acid and its derivative from carzinophilin. Chem. Pharm. Bull., 10, 2013-2019 (1971).
42) Y. Iwai, K. Komiyama, R. Oiwa, J. Awaya, I. Umezawa, S. Ōmura, and T. Hata: Studies on anti-L-1210 antibiotic produced by Streptomyces sp., No. OS-1988. Kitasato Arch. Exp. Med., 34, 71-77 (1971).
43) S. Ōmura, A. Nakagawa, H. Yamada, T. Hata, A. Furusaki, and T. Watanabe: Structure of kinamycin C, and the structural relationship among kinamycins A, B, C and D (comm.). Chem. Pharm. Bull., 19, 2428-2430 (1971).
44) T. Sato, K. Yamaguchi, M. Katagiri, J. Awaya, Y. Iwai, S. Ōmura, and T. Hata: Studies on antibiotic O-2867, a new antibiotic. J. Antibiot., 24, 774-778 (1971).
45) T. Hata, S. Ōmura, M. Katagiri, K. Atsumi, and J. Awaya: A new antifungal antibiotic, prumycin. J. Antibiot., 24, 900-901 (1971).
46) T. Hata and S. Ōmura: Chemical and biological studies on leucomycins (kitasamycins) (Review article). In "Drug Action and Drug Resistance in Bacteria" (Ed. by S. Mitsuhashi) 267-291, University of Tokyo Press, Tokyo (1971).
47) Y. Iwai, K. Komiyama, R. Oiwa, J. Awaya, I. Umezawa, S. Ōmura, and T. Hata: Studies on water-soluble antitumor antibiotics produced by Streptomyces sp., No. OS-786. Kitasato Arch. Exp. Med., 44, 95-105 (1971).
48) S. Nomura, T. Horiuchi, S. Ōmura, and T. Hata: The action of mechanism of cerulenin. J. Biochem., 71, 783-796 (1972).
49) S. Koto, S. Zen, S. Ōmura, and T. Hata: The synthesis of purine nucleosides of L-mycarose and L-cladinose. Bull. Chem. Soc. Jpn., 45, 532-535 (1972).
50) S. Nomura, T. Horiuchi, T. Hata and S. Ōmura: Inhibition of sterol and fatty acid biosyntheses by cerulenin in cell-free systems of yeast. J. Antibiot., 25, 365-368 (1972).
51) D. Vance, I. Goldberg, O. Mitsuhashi, K. Bloch, S. Ōmura, and S. Nomura: Inhibition of fatty acid synthetases by the antibiotic cerulenin. Biochem. Biophys. Res. Commun., 48, 649-656 (1972).
52) S. Ōmura, M. Tishler, M. Katagiri, and T. Hata: Structure of prumycin, 2,5-diamino-2,5-dideoxypentose containing antibiotic. J. Chem. Soc., Chem. Commun., 1972, 633-634 (1972).
53) S. Ōmura, A. Nakagawa, N. Yagisawa, Y. Suzuki, and T. Hata: Chemistry of leucomycins -X. Conformational studies of leucomycin. Tetrahedron, 28, 2839-2848 (1972).
54) S. Ōmura, Y. Hironaka, A. Nakagawa, I. Umezawa, and T. Hata: Antimycoplasma activities of macrolide antibiotics. J. Antibiot., 25, 105-108 (1972).
55) S. Koto, K. Yago, S. Zen, S. Ōmura, and T. Hata: Synthesis of anomeric methyl 6-O-(L-mycarosyl)-b-D-glucosaminides. Chem. Lett., 1, 731-732 (1972).
56) A. Furusaki, M. Matsui, T. Watanabe, S. Ōmura, A. Nakagawa, and T. Hata: The crystal and molecular structure of kinamycin C-p-bromo-benzoate. Israel J. Chem., 10, 173-187 (1972).
57) S. Ōmura, M. Tishler, A. Nakagawa, Y. Hironaka, and T. Hata: Relationships of structure and microbiological activities of the 16-membered macrolides. J. Med. Chem., 15, 1011-1015 (1972).
58) S. Koto, K. Yago, S. Zen, and S. Ōmura: The synthesis of anomeric methyl 4-O-L-mycarosyl-b-D-mycaminosides. Chem. Lett., 1, 1091-1092 (1972).
59) T. Hata, S. Ōmura, Y. Iwai, H. Ohno, H. Takeshima, and N. Yamaguchi: Studies on penicillinase inhibitor produced by microorganisms. J. Antibiot., 25, 473-474 (1972).
60) S. Ōmura, A. Nakagawa, H. Yamada, T. Hata, A. Furusaki, and T. Watanabe: Structures and biological properties of kinamycins A, B, C, and D. Chem. Pharm. Bull., 21, 931-940 (1973).
61) Y. Iwai, J. Awaya, T. Kesado, H. Yamada, S. Ōmura, and T. Hata: Selective production of cerulenin by Cephalosporium caerulens KF-140. J. Ferm. Technol., 51, 575-581 (1973).
62) H. Ohno, J. Awaya, S. Ōmura, S. Sakamoto, and T. Hata: A new proteolytic enzyme having milk clotting activity from Streptomyces sp. No. OS-1000. J. Ferm. Technol., 51, 609-612 (1973).
63) M. Onda, Y. Konda, Y. Narimatsu, S. Ōmura, and T. Hata: Structure of pyrindicin. Chem. Pharm. Bull., 21, 2048-2049 (1973).
64) H. Ohno, A. Matsumae, Y. Iwai, M. Nakae, S. Ōmura, and T. Hata: In vitro and in vivo activity of penicillinase inhibitor, KA-107 against Staphylococcus aureus FS-1277. Antimicrob. Agents Chemother., 4, 226-230 (1973).
65) Y. Iwai, H. Ohno, H. Takeshima, N. Yamaguchi, S. Ōmura, and T. Hata: Screening and isolation of the penicillinase inhibitor, KA-107. Antimicrob. Agents Chemother., 4, 222-225 (1973).
66) S. Ōmura, M. Katagiri, J. Awaya, K. Atsumi, R. Oiwa, T. Hata, S. Higashikawa, K. Yasui, H. Terada, and S. Kuyama: Production and isolation of a new antifungal antibiotic, prumycin and taxonomic studies of Streptomyces sp., strain No. F-1028. Agricult. Biol. Chem., 37, 2805-2812 (1973).
67) S. Koto, K. Yago, S. Zen, and S. Ōmura: Synthesis of anomeric methyl 6-O-(L-mycarosyl)-b-D-glucosaminides and 4-O-(L-mycarosyl)-b-D-mycaminosides. Bull. Chem. Soc. Jpn., 46, 3800-3804 (1973).
68) S. Ōmura, Y. Suzuki, A. Nakagawa, and T. Hata: Fast liquid chromatography of macrolide antibiotics. J. Antibiot., 26, 794-796 (1973).
69) G. D'Agnolo, I. S. Rosenfeld, J. Awaya, S. Ōmura, and P. R. Vagelos: Inhibition of fatty acid synthesis by the antibiotic cerulenin. Specific inactivation of b-ketoacyl-acyl carrier protein synthetase. Biochim. Biophys. Acta, 326, 155-166 (1973).
70) S. Ōmura and H. Takeshima: Inhibition of the biosynthesis of leucomycin, a macrolide antibiotic, by cerulenin. J. Biochem. 75, 193-195 (1974).
71) B. H. Arison and S. Ōmura: Revised structure of cerulenin. J. Antibiot., 27, 28-30 (1974).
72) S. Ōmura, A. Nakagawa, K. Suzuki, T. Hata, A. A. Jakubowski, and M. Tishler: Isolation and structure of leuconolide A3 5,18-hemiacetal and 9-dehydro-18-dihydroleucomycin A3. J. Antibiot., 27, 147-149 (1974).
73) T. Ohno, T. Kesado, J. Awaya, and S. Ōmura: Target of inhibition by the anti-lipogenic antibiotic cerulenin of sterol synthesis in yeast. Biochem. Biophys. Res. Commun., 57, 1119-1124 (1974).
74) S. Ōmura, H. Tanaka, Y. Koyama, R. Oiwa, M. Katagiri, J. Awaya, T. Nagai, and T. Hata: Nanaomycins A and B, new antibiotics produced by a strain of Streptomyces. J. Antibiot., 27, 363-365 (1974).
75) S. Ōmura, A. Nakagawa, K. Suzuki, and T. Hata: A new bicyclo lactone from leucomycin A3 by alkali treatment. J. Antibiot., 27, 370-372 (1974).
76) S. Ōmura, H. Tanaka, J. Awaya, Y. Narimatsu, Y. Konda, and T. Hata: Pyrindicin, a new alkaloid from a Streptomyces strain. Taxonomy, fermentation, isolation and biological activity. Agricult. Biol. Chem., 38, 899-906 (1974).
77) A. Nakagawa, K. Suzuki, K. Iwasaki, T. Hata and S. Ōmura: Chemistry of leucomycins. XI. Chemical transformation of a basic macrolide to a neutral macrolide. Chem. Pharm. Bull., 22, 1426-1428 (1974).
78) J. L. Schwartz, M. Katagiri, S. Ōmura, and M. Tishler: The mechanism of prumycin action. J. Antibiot., 27, 379-385 (1974).
79) T. Ohno, D. B. P. Goodman, H. Rasmussen, and S. Ōmura: A new type of sodium transport inhibitor in the toad bladder. J. Membrane Biol., 18, 295-304 (1974).
80) K. Satoh. K. Komiyama, C. Kitao, Y. Iwai, K. Atsumi, R. Oiwa, M. Katagiri, I. Umezawa, S. Ōmura, and T. Hata: Isolation and characterization of a new antitumor antibiotic, OS-3256-B from Streptomyces candidus var. azaticus. J. Antibiot., 27, 620-625 (1974).
81) M. Onda, Y. Konda, Y. Narimatsu, H. Tanaka, J. Awaya, and S. Omura: Alkaloid from Streptomyces sp. NA-337. Chem. Pharm. Bull., 22, 2916-2920 (1974).
82) S. Ōmura, M. Katagiri, J. Awaya, T. Furukawa, I. Umezawa, N. Oi, M. Mizoguchi, B. Aoki, and M. Shindo: Relationship between the structures of fatty acid amide derivatives and their antimicrobial activities. Antimicrob. Agents Chemother., 6, 207-215 (1974).
83) S. Ōmura, M. Katagiri, K. Atsumi, T. Hata, A. A. Jakubowski, E. B. Springs, and M. Tishler: Structure of prumycin. J. Chem. Soc. Chem. Commun., 1974, 1627-1631 (1974).
84) T. Ohno, J. Awaya, T. Kesado, S. Nomura, and S. Ōmura: Mechanism of action of CM-55, a synthetic analogue of the antilipogenic antibiotic cerulenin. Antimicrob. Agents Chemother., 6, 387-392 (1974).
85) S. Ōmura and J. Awaya: Effects of cerulenin on lipid metabolism. Kagaku to Seibutsu, 12, 787-794 (1974).
86) S. Pestka, A. Nakagawa, and S. Ōmura: Effect of leucomycins and analogues on binding [14C]-erythromycin to Escherichia coli ribosomes. Antimicrob. Agents Chemother., 6, 606-612 (1974).