Publications: 1995-1999

561) X.-H. Huang, H. Tomoda, H. Nishida, R. Masuma, and S. Ōmura: Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. I. Production, isolation and biological properties. J. Antibiot., 48, 1-4 (1995).

562) X.-H. Huang, H. Nishida, H. Tomoda, N. Tabata, K. Shiomi, D.-J. Yang, H. Takayanagi, and S. Ōmura: Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. II. Structure elucidation of terpendoles A, B, C and D. J. Antibiot., 48, 5-11 (1995).

563) N. Tabata, H. Tomoda, R. Masuma, Y. Iwai, and S. Ōmura: Fudecalone, a new anticoccidial agent produced by Penicillium sp. FO-2030. J. Antibiot., 48, 53-58 (1995).

564) C.-H. Pang, K. Matsuzaki, H. Ikeda, H. Tanaka, and S. Ōmura: Production of 6,8α-seco-6,8α-deoxy derivatives of avermectins by a mutant strain of Streptomyces avermitilis. J. Antibiot., 48, 59-66 (1995).

565) N. Tabata, H. Tomoda, Y. Iwai, and S. Ōmura: Arohynapene D, a new anticoccidial agent produced by a Penicillium sp. FO-2295. J. Antibiot., 48, 83-84 (1995).

566) C.-H. Pang, K. Matsuzaki, H. Ikeda, H. Tanaka, and S. Ōmura: Production of a new methylated 6,8α-seco-6,8α-deoxy derivatives of the avermectins by a transformant strain of Streptomyces avermitilis. J. Antibiot., 48, 92-94 (1995).

567) H. Ikeda, Y. Takada, C.-H. Pang, K. Matsuzaki, H. Tanaka, and S. Ōmura: Direct production of 5-oxo derivatives of avermectins by a recombinant strain of Streptomyces avermitilis. J. Antibiot., 48, 95-97 (1995).

568) T. Kobayashi, R. Masuma, S. Ōmura, and K. Watanabe: Materials from the fungus flora of Japan (47). Mycoscience, 35, 399-401 (1994).

569) H. Yamada, K. Shiomi, Q. Xu, T. Nagai, M. Shibata, I. Oya, Y. Takahashi, and S. Ōmura: New glycosidases inhibitors, panosialins D and wD produced by Streptomyces sp. OH-5186. J. Antibiot., 48, 205-210 (1995).

570) Y. Honma, Y. Matsuo, Y. Hayashi, and S. Ōmura: Treatment of Philadelphia-chromosome-positive human leukemia in scid mouse model with herbimycin A, bcr-abl tyrosine kinase activity inhibitor. Int. J. Cancer, 60, 685-688 (1995).

571) M. Katagiri, M. Hayashi, K. Matsuzaki, H. Tanaka, and S. Ōmura: The neurito inducer lactacystin arrests cell cycle at both G0/G1 and G2 phases in Neuro 2a cells. J. Antibiot., 48, 344-346 (1995).

572) Y. Takahashi, M. Shinose, Y. Iwai, and S. Ōmura: Transfer of staurosporine-producing strain Streptomyces staurosporeus AM-2282 to the genus Saccharothrix as Saccharothrix aerocolonigenes (labeda 1986) subsp. staurosporeus subsp. nov. Actinomycetol., 9, 19-26 (1995).

573) S. Kakinuma, H. Ikeda, Y. Takada, H. Tanaka, D. A. Hopwood and S. Ōmura: Production of the new antibiotic tetrahydrokalafungin by transformants of the kalafungin producer Streptomyces tanashiensis. J. Antibiot., 48, 484-487 (1995).

574) H. Tomoda, N. Tabata, D.-J. Yang, H. Takayanagi, H. Nishida, and S. Ōmura: Pyripyropenes, novel ACAT inhibitors produced by Aspergillus fumigatus. III. Structure elucidation of pyripyropenes E to L. J. Antibiot., 48, 495-503 (1995).

575) H. Ikeda, C.-H. Pang, H. Endo, T. Ohta, H. Tanaka, and S. Ōmura: Construction of a single component producer from the wild type avermectin producer Streptomyces avermitilis. J. Antibiot., 48, 532-534 (1995).

576) S. Ōmura, Y. Sasaki, Y. Iwai, and H. Takeshima: Staurosporine, a potentially important gift from a microorganism. J. Antibiot., 48, 535-548 (1995).

577) H. Ikeda and S. Ōmura: Control of avermectin biosynthesis in Streptomyces avermitilis for the selective production of a useful component. J. Antibiot., 48, 549-562 (1995).

578) N. Arai, K. Shiomi, H. Tomoda, N. Tabata, D. J. Yang, R. Masuma, T. Kawakubo, and S. Ōmura: Isochromophilones III-VI, inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium multicolor FO-3216. J. Antibiot., 48, 696-702 (1995).

579) K. Matsuzaki, H. Ikeda, R. Masuma, H. Tanaka, and S. Ōmura: Isochromophilones I and II, novel inhibitors against gp120-CD4 binding produced by Penicillium multicolor FO-2338. I. Screening, taxonomy, fermentation, isolation and biological activity. J. Antibiot., 48, 703-707 (1995).

580) K. Matsuzaki, H. Tanaka, and S. Ōmura: Isochromophilones I and II, novel inhibitors against gp120-CD4 binding produced by Penicillium multicolor FO-2338. J. Antibiot., 48, 708-713 (1995).

581) K. Shiomi, N. Arai, M. Shinose, Y. Takahashi, H. Yoshida, J. Iwabuchi, Y. Tanaka, and S. Ōmura: New antibiotics phthoxazolines B, C and D produced by Streptomyces sp. KO-7888. J. Antibiot., 48, 714-719 (1995).

582) Y. Tanaka, M. Sugoh, W.Ji, J. Iwabuchi, H. Yoshida, and S. Ōmura: Screening method for cellulose biosynthesis inhibitors with herbicidal activity. J. Antibiot., 48, 720-724 (1995).

583) S. Ōmura, F. Kuno, K. Otoguro, T. Sunazuka, K. Shiomi, R. Masuma, and Y. Iwai: Arisugacin, a novel and selective inhibitor of acetyl-cholinesterase from Penicillium sp. FO-4259. J. Antibiot., 48, 745-746 (1995).

584) T. Nagamitsu, T. Sunazuka, H. Stump, R. Obata, S. Arima, K. Matsuzaki, H. Tanaka, and S. Ōmura: Structure-activity relationships of lactacystin, the first non-protein neurotrophic factor. J. Antibiot., 48, 747-748 (1995).

585) R. Obata, T. Sunazuka, L. Zhuorong, H. Tomoda, and S. Ōmura: Structure-activity relationships of pyripyropenes fungal acyl-CoA: cholesterol acyltransferase inhibitors. J. Antibiot., 48, 749-750 (1995).

586) H. Tomoda, N. Tabata, D.-J. Yang, H. Takayanagi, and S. Ōmura: Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. III. Production, isolation and structure elucidation of new components. J. Antibiot., 48, 793-804 (1995).

587) H. Tomoda, M. Ito, N. Tabata, R. Masuma, Y. Yamaguchi, and S. Ōmura: Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties. J. Antibiot., 48, 937-941 (1995).

588) H. Tomoda, N. Tabata, M. Ito, and S. Ōmura: Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C. J. Antibiot., 48, 942-947 (1995).

589) S. Takahashi, K. Uchida, A. Nakagawa, Y. Miyake, M. Kainosho, K. Matsuzaki, and S. Ōmura: Biosynthesis of lactacystin. J. Antibiot., 48, 1015-1020 (1995).

590) K. Komiyama, S. Takamatsu, Y.-P. Kim, A. Matsumoto, Y. Takahashi, M. Hayashi, H. Boyd Woodruff, and S. Ōmura: Louisianins A, B, C and D: Non-steroidal growth inhibitors of testosterone-responsive SC115 cells. I. Taxonomy, fermentation, isolation and biological characteristics. J. Antibiot., 48, 1086-1089 (1995).

591) S. Takamatsu, Y.-P. Kim, M. Hayashi, K. Furuhata, H. Takayanagi, K. Komiyama, H. Boyd Woodruff, and S. Ōmura: Louisianins A, B, C and D: Non-steroidal growth inhibitors of testosterone-responsive SC 115 cells. II. Physico-chemical properties and structural elucidation. J. Antibiot., 48, 1090-1094 (1995).

592) H. Tanaka, M. Katagiri, S. Arima, K. Matsuzaki, J. Inokoshi, and S. Ōmura: Neuronal differentiation of neuro 2A cells by lactacystin and its partial inhibition by the protein phosphatase inhibitors calyculin A and okadaic acid. Biochem. Biophys. Res. Commun., 216, 291-297 (1995).

593) C. L. Ward, S. Ōmura, and R. R. Kopito: Degradation of CFTR by the ubiquitin-proteasome pathway. Cell, 83, 121-127 (1995).

594) S. Mori, K. Tanaka, S. Ōmura, and Y. Saito: Degradation process of ligand-stimulated platelet-derived growth factor β-receptor involves ubiquitin-proteasome proteolytic pathway. J. Biol. Chem., 270, 29447-29452 (1995).

595) K. Shiomi, H. Yang, Q. Xu, N. Arai, M. Namiki, M. Hayashi, J. Inokoshi, H. Takeshima, R. Masuma, K. Komiyama, and S. Ōmura: Phenopyrrozin, a new radical scavenger produced by Penicillium sp. FO-2047. J. Antibiot., 48, 1413-1418 (1995).

596) R. Obata, T. Sunazuka, H. Tomoda, Y. Harigaya, and S. Ōmura: Chemical modification and structure-activity relationships of pyripyropenes; potent, bioavailable inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT). Bioorg. Med. Chem. Lett., 5, 2683-2688 (1995).

597) M. Hayashi, Y.-P. Kim, H. Hiraoka, M. Natori, S. Takamatsu, T. Kawakubo, R. Masuma, K. Komiyama, and S. Ōmura: Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. I. Taxonomy, fermentation, isolation and biological activities. J. Antibiot., 48, 1435-1439 (1995).

598) Y. Tanaka, M. Sugoh, H. Yoshida, N. Arai, K. Shiomi, A. Matsumoto, Y. Takahashi, and S. Ōmura: Hydranthomycin, a new agroactive antibiotic produced by Streptomyces sp. K93-5305. J. Antibiot., 48, 1525-1526 (1995).

599) S. J.-Ohmi, T. Kawaguchi, S. Sugiyama, K. Tanaka, S. Ōmura, and H. Kikuchi: Lactacystin, a specific inhibitor of the proteasome, induces apoptosis in human monoblast U937 cells. Biochem. Biophys. Res. Commun., 217, 1070-1077 (1995).

600) T. Nagamitsu, T. Sunazuka, R. Obata, H. Tomoda, H. Tanaka, Y. Harigaya, S. Ōmura, and A. B. Smith, III: Total synthesis of (+)-pyripyropene, a potent orally bioavailable inhibitor of acyl-CoA:cholesterol acyltransferase. J. Org. Chem., 60, 8126-8127 (1995).

601) Y. Enomoto, K. Shiomi, M. Hayashi, R. Masuma, T. Kawakubo, K. Tomosawa, Y. Iwai, and S. Ōmura: Herquline B, a new platelet aggregation inhibitor produced by Penicillium herquei Fg-372. J. Antibiot., 49, 50-53 (1996).

602) S. Takamatsu, Y.-P. Kim, M. Hayashi, H. Hiraoka, M. Natori, K. Komiyama, and S. Ōmura: Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. II. Physicochemical properties and structural elucidation. J. Antibiot., 49, 95-98 (1996).

603) Y. Morikawa, S. Hinata, H. Tomoda, T. Goto, M. Nakai, C. Aizawa, H. Tanaka, and S. Ōmura: Complete inhibition of human immunodeficiency virus (HIV) gag myristoylation is necessary for inhibition of particle budding. J. Biol. Chem., 271, 2868-2873 (1996).

604) H. Tomoda, T. Tabata, Y. Nakata, H. Nishida, T. Kaneko, R. Obata, T. Sunazuka, and S. Ōmura: Biosynthesis of pyripyropene A. J. Org. Chem., 61, 882-886 (1996).

605) K. Shiomi, R. Uchida, J. Inokoshi, H. Tanaka, Y. Iwai, and S. Ōmura: Andrastins A-C, new protein farnesyltransferase inhibitors, produced by Penicillium sp. FO-3929. Tetrahedron Lett., 37, 1265-1268 (1996).

606) K. Oda, Y. Ikehara, and S. Ōmura: Lactacystin, an inhibitor of the proteasome, blocks the degradation of a mutant precursor of glycosylphosphatidyl-inositol-linked protein in a Pre-Golgi compartment. Biochem. Biophys. Res. Commun., 219, 800-805 (1996).

607) D.-J. Yang, H. Tomoda, N. Tabata, R. Masuma, and S. Ōmura: New isochromophilones VII and VIII produced by Penicillium sp. FO-4164. J. Antibiot., 49, 223-229 (1996).

608) N. Tabata, H. Tomoda, Y. Iwai, and S. Ōmura: Xanthoquinodin B3, a new anticoccidial agent produced by Humicola sp. FO-888. J. Antibiot., 49, 267-271 (1996).

609) H. Tomoda, N. Tabata, D.-J. Yang, I. Namatame, H. Tanaka, and S. Ōmura: Pyripyropenes, novel ACAT inhibitors produced by Aspergillus fumigatus IV. J. Antibiot., 49, 292-298 (1996).

610) K. Katagiri, K. K.Yokoyama, T. Hamamoto, S. Ōmura, S. Irie, and T. Katagiri: Lyn and Gfr protein-tyrosine kinases prevent apoptosis during retinoic acid-induced granulocytic differentiation of HL-60 cells. J. Biol. Chem., 271, 11557-11562 (1996).

611) S. Ōmura and H. Takeshima: Lactacystin: a tool for elucidation of proteasome functions. Tanpakushitsu Kakusan Koso, 41, 327-336 (1996).

612) N. Inatomi, F. Sato, S. Marui, Z. Itoh, and S. Ōmura: Vagus-dependent and vagus-independent mechanisms of action of the erythromycin derivative EM 574 and motilin in dogs. Jpn. J. Pharmacol., 71, 29-38 (1996).

613) N. Tanaka, M. Naganuma, M. Fukuda, Y. Wati, K. Komatu, S. Yoshida, K. Komiyama, and S. Ōmura: Novel inhibitor of melanogenesis produced by Talaromyces FO-3182. J. Jpn. Cosmetic Sci. Soc., 20, 3-6 (1996).

614) S. Ōmura, J. Inokoshi, R. Uchida, K. Shiomi, R. Masuma, T. Kawakubo, H. Tanaka, Y. Iwai, S. Kosemura, and S. Yamamura: Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. I. Producing strain, fermentation, isolation, and biological activities. J. Antibiotics, 49, 414-417 (1996).

615) R. Uchida, K. Shiomi, J. Inokoshi, T. Sunazuka, H. Tanaka, Y. Iwai, H. Takayanagi, and S. Ōmura: Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. II. Structure elucidation and biosynthesis. J. Antibiotics, 49, 418-424 (1996).

616) S. Takamatsu, Y.-P. Kim, M. Hayashi, K. Komiyama, G. Imokawa, and S. Ōmura: A new inhibitor of melanogenesis, albocycline K3, produced by Streptomyces sp. OH-3984. J. Antibiotics, 49, 485-486 (1996).

617) Y. Takahashi, Y. Iwai, and S. Ōmura: Physiological regulation of sporulation of Kitasatosporia setae in submerged culture. Actinomycetol. 10, 43-49 (1996)

618) H. Yoshida, K. Kitamura, K. Tanaka, S. Ōmura, T. Miyazaki, T. Hachiya, R. Ohno, and T. Naoe: Accelerated degradation of PML-retinoic acid receptor a (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway. Cancer Res., 56, 2945-2948 (1996).

619) M. Hayashi, Y.-P. Kim, S. Takamatsu, S. Preeprame, T. Komiya, R. Masuma, H. Tanaka, K. Komiyama, and S. Ōmura: Chlovalicin, a new cytocidal antibiotic produced by Sporothrix sp. FO-4649. I. Taxonomy, fermentation, isolation and biological activities. J. Antibiotics 49, 631-634 (1996).

620) S. Takamatsu, Y.-P. Kim, T. Komiya, T. Sunazuka, M. Hayashi, H. Tanaka, K. Komiyama, and S. Ōmura: Chlovalicin, a new cytocidal antibiotic produced by Sporothrix sp. FO-4649. II. Physicochemical properties and structural elucidation. J. Antibiotics 49, 635-638 (1996).

621) S. Ōmura and H. Tomoda: Lactacystin, a specific inhibitor of proteasome: from its discovery to its application (Review article). Cell Technology, 15, 929-940 (1996).

622) A. Nakagawa and S. Ōmura: Biosynthesis of bioactive microbial metabolites and its application to the structural studies and production of hybrid compounds (Review article). J. Antibiotics, 49, 717-741 (1996).

623) F. Kuno, K. Otoguro, K. Shiomi, Y. Iwai, and S. Ōmura: Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. I. Screening, taxonomy, fermentation, isolation and biological activity. J. Antibiotics, 49, 742-747 (1996).

624) F. Kuno, K. Shiomi, K. Otoguro, T. Sunazuka, and S. Ōmura: Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. II. Structure elucidation. J. Antibiotics, 49, 748-751 (1996).

625) Y. Funabashi, Y. Maeshiba, N. Inatomi, S. Tanayama, S. Harada, Z. Itoh, and S. Ōmura: Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity. J. Antibiotics, 49, 794-801 (1996).

626) Y. Funabashi, S. Hakoda, N. Inatomi, K. Koyama, S. Tanida, S. Harada, Z. Itoh, and S. Ōmura: Microbial conversion of EM574 and EM523, gastrointestinal motor stimulating agents. J. Antibiotics, 49, 802-810 (1996).

627) Y. Murakami, N. Tanahashi, K. Tanaka, S. Ōmura, and S. Hayashi: Proteasome pathway operates for the degradation of ornithine decarboxylase in intact cells. Biochem. J., 317, 77-80 (1996).

628) T. Nagamitsu, T. Sunazuka, H. Tanaka, S. Ōmura, P. A. Sprengeler, and A. B. Smith, III: Total synthesis of (+)-lactacystin. J. Am. Chem. Soc., 118, 3584-3590 (1996).

629) S. Ōmura and K. Shiomi: Drug discovery and microbial secondary metabolites (Review article). Bioscience and Industry, 54, 633-635 (1996).

630) S. Ōmura: Feature of antibiotics in the 21st century (Review article). Jpn. J. Antibiotics, 49, 755-765 (1996).

631) T. Sunazuka and S. Ōmura: Chemistry and synthetic study of lactacystin, the first non-protein neurotrophic factor. J. Syn. Org. Chem., Jpn., 54, 740-751 (1996).

632) E. Fujita, T. Mukasa, T. Tsukahara, K. Arahata, S. Ōmura, and T. Momoi: Enhancement of CPP32-like activity in TNF-treated U937 cells by the proteasome inhibitors. Biochem. Biophys. Res. Commun., 224, 74-79 (1996).

633) R. Uchida, K. Shiomi, T. Sunazuka, J. Inokoshi, A. Nishizawa, T. Hirose, H. Tanaka, Y. Iwai, and S. Ōmura: Kurasoins A and B, new protein farnesyltransferase inhibitors produced by Paecilomyces sp. FO-3684. II. Structure elucidation and total synthesis. J. Antibiotics, 49, 886-889 (1996).

634) H. Tomoda, Y. Yamaguchi, N. Tabata, T. Kobayashi, R. Masuma, H. Tanaka, and S. Ōmura: Amidepsine E, an inhibitor of diacylglycerol acyltransferase produced by Humicola sp. FO-5969. J. Antibiotics, 49, 929-931 (1996).

635) R. Uchida, K. Shiomi, J. Inokoshi, R. Masuma, T. Kawakubo, H. Tanaka, Y. Iwai, and S. Ōmura: Kurasoins A and B, new protein farnesyltransferase inhibitors produced by Paecilomyces sp. FO-3684. I. Producing strain, fermentation, isolation and biological activities. J. Antibiotics, 49, 932-934 (1996).

636) F. Sztaricskai, Z. Kinya, M. M. Puskas, G. Batta, R. Masuma, and S. Ōmura: Semisynthetic modification of antibiotic lincomycin. J. Antibiotics, 49, 941-943 (1996).

637) A. B. Smith, III, T. Kinsho, T. Sunazuka and S. Ōmura: Biomimetic total synthesis of the ACAT inhibitor (+)-pyripyropene E. Tetrahedron Lett., 37, 6461-6464 (1996).

638) R. Yamada, K. Fukuda, M. Kawanishi, Y. Ohmori, M. Nasu, M. Seto, Y. Sasaki, T. Sunazuka, L. Zhuorong, N. Funato, M. Iguchi, Y. Harigaya, Y. Iwai, and S. Ōmura: Synthesis and activity of staurosporine analogs with a lactone functionality. Bioorganic and Med. Chem. Lett., 6, 1893-1896 (1996).

639) Y. Tanaka, K. Matsuzaki, C.-L. Zhong, H. Yoshida, T. Kawakubo, R. Masuma, H. Tanaka, and S. Ómura: Dechlorogeodin and its new dihydro derivatives, fungal metabolites with herbicidal activity. J. Antibiot., 49, 1056-1059 (1996).

640) R. Yamada. M. Seto, Y. Sasaki, T. Sunazuka, Y. Harigaya, Y. Iwai, and S. Ōmura: Synthesis and anti-platelet aggregation activity of water-soluble staurosporine derivatives. J. Antibiot., 49, 1070-1072 (1996).

641) T. P. McGee, H. H. Cheng, H. Kumagai, S. Ōmura, and R. D. Simoni: Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increase susceptibility to proteolysis. J. Biol. Chem., 271, 25630-25638 (1996).

642) M. V. Blagosklonny, G. S. Wu, S. Ōmura, and W. S. El-Diery: Proteasome-dependent regulation of p21WAF1/CiP1 expression. Biochem. Biophys. Res. Commun., 227, 564-569 (1996).

643) H. Miura, H. Tomoda, K. Miura, K. Takishima, and S. Ōmura: Lactacystin increase LDL receptor level on HepG2 cells. Biochem. Biophys. Res. Commun., 227, 684-687 (1996).

644) R. Obata, T. Sunazuka, Z. Li, Z. Tian, Y. Harigaya, N. Tabata, H. Tomoda, and S. Ōmura: Chemical modification and structure-activity relationships of pyripyropenes. I. Modification at the four hydroxyl groups. J. Antibiot., 49, 1133-1148 (1996).

645) R. Obata, T. Sunazuka, Y. Kato, H. Tomoda, Y. Harigaya, and S. Ōmura: Chemical modification and structure-activity relationships of pyripyropenes. II. 1,11-Cyclic analogs. J. Antibiot., 49, 1149-1156 (1996).

646) H. Ikeda and S. Ōmura: Production of useful microbial secondary metabolites by engineered biosynthesis (Review article). Kagaku to Seibutsu, 34, 761-771 (1996).

647) M. Hayashi, Y.-P. Kim, S. Takamatsu, A. Enomoto, M. Shinose, Y. Takahashi, H. Tanaka, K. Komiyama, and S. Ōmura: Madindoline, a novel inhibitor of IL-6 activity from Streptomyces sp. K93-0711. I. Taxonomy, fermentation, isolation and biological activities. J. Antibiot., 49, 1091-1093 (1996).

648) Y. Takahashi, A. Matsumoto, A. Seino, Y. Iwai, and S. Ōmura: Rare actinomycetes isolated from desert soil. Actinomycetol. 10, 91-97 (1996).

649) H. Gouda, K. Matsuzaki, H. Tanaka, S. Ōmura, J. A. McCauley, P. A. Sprengeler, G. T. Furst, and A. B. Smith, III: Stereostructure of (-)-chloropeptin I, a novel inhibitor of gp120-CD4 binding, via high-temperature molecular dynamics, Monte Carlo Conformational searching, and NMR spectroscopy. J. Am. Chem. Soc., 118, 13087-13088 (1996).

650) R. Uchida, K. Shiomi, J. Inokoshi, H. Tanaka, Y. Iwai, and S. Ōmura: Andrastin D, novel protein farnesyltransferase inhibitor produced by Penicillium sp. FO-3929. J. Antibiot., 49, 1278-1280 (1996).

651) H. Tanaka, K. Matsuzaki, H. Nakashima, T. Ogino, A. Matsumoto, H. Ikeda, H. Boyd Woodruff, and S. Ōmura: Chloropeptins, new anti-HIV antibiotics inhibiting gp120-CD4 binding from Streptomyces sp. I. Taxonomy, fermentation, isolation, and physico-chemical properties and biological activities. J. Antibiot., 50, 58-65 (1997).

652) K. Matsuzaki, T. Ogino, T. Sunazuka, H. Tanaka, and S. Ōmura: Chloropeptins, new anti-HIV antibiotics inhibiting gp120-CD4 binding from Streptomyces sp. II. Structure elucidation of chloropeptin I. J. Antibiot., 50, 66-69 (1997).

653) M. Jeffers, G. A. Taylor, K. M. Weidner, S. Ōmura, and G. V. Woude: Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway. Mol. Cell. Biol., 17, 799-808 (1997).

654) R. J. Rayanade, K. Patel, M. Ndubuisit, S. Sharma, S. Ōmura, J. D. Etlinger, R. Pine, and P. B. Sehgal: Proteasome- and p53-dependent masking of signal transducer and activator of transcription (STAT) factors. J. Biol. Chem., 272, 4659-4662 (1997).

655) Y.-P. Kim, S. Takamatsu, M. Hayashi, K. Komiyama, and S. Ōmura: Pyridindolols K1 and K2, new alkaloids from Streptomyces sp. K93-0711. J. Antibiot., 50, 189-193 (1997).

656) Y. Tanaka, H. Yoshida, Y. Enomoto, K. Shiomi, M. Shinose, Y. Takahashi, J.-R. Liu, and S. Ōmura: Malolactomycins C and D, new 40-membered macrolides active against Botrytis. J. Antibiot., 50, 194-200 (1997).

657) R. Obata, T. Sunazuka, Z. Tian, H. Tomoda, Y. Harigaya, and S. Ōmura: Chemical modification and structure-activity relationships of pyripyropenes. 3. Synthetic conversion of pyridine-pyrone moiety. J. Antibiot., 50, 229-236 (1997).

658) T. Sunazuka, T. Zhi-Ming, Y. Harigaya, S. Takamatsu, M. Hayashi, K. Komiyama, and S. Ōmura: Efficient chemical conversion of louisianin A to C and D, the inhibitor of angiogenesis. J. Antibiot., 50, 274-275 (1997).

659) S. C. Munday-Finch, A. L. Wilkins, C. O. Miles, H. Tomoda, and S. Ōmura: Isolation and structure elucidation of lolilline, a possible biosynthetic precursor of the lolitrem family of tremorgenic mycotoxins. J. Agricult. Food Chem., 45, 199-204 (1997).

660) S. Ōmura: Biologically active microbial metabolites. In "Medicinal Chemistry: Today and Tomorrow" (Ed. by M. Yamazaki) 43-48 (1997).

661) H. Tomoda, H. Kumagai, Y. Ogawa, T. Sunazuka, H. Hashizume, H. Nagashima, and S. Omura: Synthesis of four chiral isomers of β-lactone DU-6622 and inhibition of HMG-CoA synthase by the specific (2R,3R)-isomer. J. Org. Chem., 62, 2161-2165 (1997).

662) F. Sato, M. Sekiguchi, S. Marui, N. Inatomi, A. Shino, Z. Itoh, and S. Ōmura: EM-574, an erythromycin derivative, is a motilin receptor agonist in the rabbit. E. J. Pharmacol., 322, 63-71 (1997).

663) T. Sunazuka, T. Hirose, T. Z.-Ming, R. Uchida, K. Shiomi, Y. Harigaya, and S. Ōmura: Synthesis and absolute structures of novel protein farnesyltransferase inhibitors, kurasoins A and B. J. Antibiot., 50, 453-455 (1997).

664) H. Tanaka, K. Matsuzaki, and S. Ōmura: gp120-CD4 binding inhibitors having anti-HIV activity (Review Article). Nippon Nogeikagaku Kaishi 71, 530-534 (1997).

665) H. Ostrowska, C. Wojcik, S. Ōmura, and K. Worowski: Lactacystin, a specific inhibitor of the proteasome, inhibits human platelet lysosomal cathepsin A-like enzyme. Biochem. Biophys. Res. Commun., 234, 729-732 (1997).

666) S.-T. Yee, Y. Okada, K. Ogasawara, S. Ōmura, A. Takatsuki, T. Kakiuchi, D. Muno, E. Kominami, and T. Mizuochi: MHC class I presentation of an exogenous polypeptide antigen encoded by the murine AIDS defective virus. Microbiol. Immunol., 41, 563-570 (1997).

667) G. Niedermann, R. Grimm, E. Greier, M. Maurer, C. Realini, C. Gartmann, J. Soll, S. Ōmura, M. C. Rechsteiner, W. Baumeister, and K. Eichmann: Potential immunocompetence of proteolytic fragments produced by proteasomes before evolution of the vertebrate immune system. J. Exp. Med., 185, 209-220 (1997).

668) F. Takeuchi, K. A. Seta, S. Ōmura, and R. A. Roth: Insulin degradation by madin-darby canine kidney cells expressing the insulin receptor. Diabetes Res. and Clin. Practice, 37, 81-90 (1997).

669) J.-P. Perchellet, S. W. Newell, J. B. Labesich, E. M. Perchellet, Y. Chen, D. H. Hua, S. L. Kraft, R. J. Basaraba, S. Ōmura, and H. Tomoda: Antitumor activity of novel tricyclic pyrone analogs in murine leukemia cells in vitro. Anticancer Res., 17, 2427-2434 (1997).

670) T. Yamazaki, C. Haas, T. C. Saido, S. Ōmura, and Y. Ihara: Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition. Biochemistry, 36, 8377-8383 (1997).

671) F. Tokunaga, H. Shirotani, K. Hara, D. Kozuki, S. Ōmura, and T. Koide: Intracellular degradation of secretion defect-type mutants of anti-thrombin is inhibited by proteasomal inhibitors. FEBS Lett., 412, 65-69 (1997).

672) H. Tanaka and S. Ōmura: Screening of novel receptor-activity compounds of microbial origin (Review article). In "Biotechnology" (Eds. H.-J. Rehm and G. Reed) 7, 107-132, VCH Verlargsgesellschaft mbH (1997).

673) N. Tabata, N. Ito, H. Tomoda, and S. Ōmura: Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus. Phytochemistry, 46, 683-687 (1997).

674) K. Matsui, S. Ōmura, H. Cui, S. L. Schauer, G. E. Sonenshein, and S.-T. Ju: Proteasome regulation of Fas ligand cytotoxicity. Eur. J. Immunol., 27, 2269-2278 (1997).

675) E. A. Fisher, M. Zhou, D. M. Mitchell, X. Wu, S. Ōmura, H. Wang, A. L. Goldberg, and H. N. Ginsberg: The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70. J. Biol. Chem., 272, 20427-20434 (1997).

676) H. Cui, K. Matsui, S. Ōmura, S. L. Schauer, R. A. Matulka, G. E. Sonenshen, and S.-T. Ju: Proteasome regulation of activation-induced T cell death. Proc. Natl. Acad. Sci. USA, 94, 7515-7520 (1997).

677) J. Magae, S. Illenye, T. Tejima, Y.-C. Chang, Y. Mitsui, K. Tanaka, S. Ōmura, and N. H. Heintz: Transcriptional squelching by ectopic expression of E2F-1 and p53 is alleviated by proteasome inhibitors MG-132 and lactacystin. Oncogene 15, 759-769 (1997).

678) S. Tanaka, K.-I. Nemoto, E. Yamamura, S. Ōmura, A. Ichikawa: Degradation of the 74 kDa form of L-histidine decarboxylase via the ubiquitin-proteasome pathway in a rat basophilic/mast cell line (RBL-2H3). FEBS Lett., 417, 203-207 (1997).

679) F. Sztaricskai, Z. Dinya, G. Batta, R. Masuma, and S. Ōmura: Linkomicin antibiotikum kemiai modositasa. Magyar Kemiai Folyoirat., 103, 524-530 (1997).

680) T. Sunazuka, T. Hirose, Y. Harigaya, S. Takamatsu, M. Hayashi, K. Komiyama, S. Ōmura, P. A. Sprengeler, and A. B. Smith, III: Relative and absolute stereochemistries and total synthesis of (+)-macrosphelides A and B, potent, orally bioavailable inhibitor of cell-cell-adhesion. J. Am. Chem. Soc., 119, 10247-10248 (1997).

681) N. Arai, K. Shiomi, S. Takamatsu, K. Komiyama, M. Shinose, Y. Takahashi, Y. Tanaka, Y. Iwai, J.-R. Liu, and S. Ōmura: Amphistin, a new melanogenesis inhibitor, produced by an acinomycete. J. Antibiot., 50, 808-814 (1997).

682) F. Sztaricskai, S. Kinya, G. Batta, A. Mocsari, M. Lollosi, Z. Majer, R. Masuma, and S. Ōmura: Chemical synthesis and structural study of lincomycin sulfoxides and a sulfone. J. Antibiot., 50, 866-873 (1997).

683) S. Takamatsu, H. Hiraoka, Y.-P. Kim, M. Hayashi, M.Natori, K. Komiyama, and S. Ōmura: Macrosphelides C and D, novel inhibitors of cell adhesion. J. Antibiot., 50, 878-880 (1997).

684) F. Fang, H. Ui, K. Shiomi, R. Masuma, Y. Yamaguchi, C. G. Zhang, X. W. Zhang, Y. Tanaka, and S. Ōmura: Two new components of the aspochalasins produced by Aspergillus sp. J. Antibiot., 50, 919-925 (1997).

685) H. Ikeda and S. Ōmura: Avermectin biosynthesis (Review article). Chem. Rev., 97, 2591-2609 (1997).

686) K. Otoguro, F. Kuno, and S. Ōmura: Arisugacins, selective acetylcholinesterase inhibitors of microbial origin. Pharmacol. Ther., 76, 45-54 (1997).

687) H. Tomoda and S. Ōmura: Application of lactacystin studies on proteasome functions (Review article, in Japanese). Tissue Culture Technol., 23, 503-506 (1997).

688) S. Takamatsu, Y.-P. Kim, A. Enomoto, M. Hayashi, H. Tanaka, K. Komiyama, and S. Ōmura: Madindolines, novel inhibitors of IL-6 activity from Streptomyces sp. K93-0711. II. Physico-chemical properties and structural elucidation. J. Antibiot., 50, 1069-1072 (1997).

689) R. Obata, T. Sunazuka, Z. Tian, H. Tomoda, Y. Harigaya, S. Ōmura, and A. B. Smith, III: New analogs of the pyripyropene family of ACAT inhibitors via α-pyrone fragmentation and α acylation/cyclization. Chem. Lett., 935-936 (1997).

690) M.-C. Rho, M. Toyoshima, M. Hayashi, R. Uchida, K. Shiomi, K. Komiyama, and S. Ōmura: Enhancement of drug accumulation by andrastin A produced by Penicillium sp. FO-3929 in vincristine-resistant KB cells. J. Antibiot., 51, 68-72 (1998).

691) J. Delic, P. Masdehora, S. Ōmura, J-M Cosset, J. Dumont, J-L Binet, and H. Magdelenat: The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukemia lymphocytes to TNF-α-initiated apoptosis. British J. Cancer, 77, 1103-1107 (1998).

692) L. Monney, I. Otter, R. Olivier, H. L. Ozer, A. L. Haas, S. Ōmura, and C. Borner. Defects in the ubiquitin pathway induce caspase-independent apoptosis blocked by Bcl-2. J. Biol. Chem., 273, 6121-6131 (1998).

693) H. Ikeda, L-R Wang, T. Ohta, J. Inokoshi, and S. Ōmura: Cloning of the gene encoding avermectin B 5-O-methyltransferase in avermectin-producing Streptomyces avermitilis. Gene, 206, 175-180 (1998).

694) Y. Tanaka, K. Shiomi, K. Kamei, M. S.-Hagino, Y. Enomoto, F. Fang, Y. Yamaguchi, R. Masuma, C. G. Zhang, X. W. Zhang, and S. Ōmura. Antimalarial activity of radicicol, heptelidic acid and other fungal metabolites. J. Antibiot., 51, 153-160 (1998).

695) Y. Tanaka, F. F. Fang, C. G. Zhang, X. W. Zhang, and S. Ōmura: Heme-dependent radical generation from antimalarial fungal metabolites, radicicol and heptelidic acid. J. Antibiot., 51, 451-453 (1998).

696) Y. Tanaka, Y. Takahashi, M. Shinose, S. Ōmura, I, I.-Karakawa, H. Iwase, and K. Hotta: Screening and fermentation of endo-α-N-acetyl-galactosaminidase S, a mucin-hydrolyzing enzyme from Streptomyces acting on the GalNAc-O-Ser(Thr) linkage. J. Ferment. Bioeng., 85, 381-387 (1998).

697) T. Oikawa, T. Sasaki, M. Nakamura, M. Shimamura, N. Tanahashi, S. Ōmura, and K. Tanaka: The proteasome is involved in angiogenesis. Biochem. Biophys. Res. Comm., 246, 243-248 (1998).

698) M. Fukushi, N. Amizuka, K. Hoshi, H. Ozawa, H. Kumagai, S. Ōmura, Y. Misumi, Y. Ikehara, and K. Oda: Intracellular retention and degradation of tissue-nonspecific alkaline phosphatase with a Gly317 - Asp substitution associated with lethal hypophosphatasia. Biochem. Biophys. Res. Comm., 246, 613-618 (1998).

699) H. Ikeda and S. Ōmura: Combinatorial biosynthesis: Engineered biosynthesis of polyketide compounds. (Review article, in Japanese). Tannpakushitu Kakusan Koso, 43, 1265-1277 (1998).

700) T. Sunazuka, T. Nagamitsu, and S. Ōmura: Synthetic study of a-pyrone meroterpenoides, pyripyropens. J. Synthetic Organic Chem., Japan, 56, 478-488 (1998).

701) A. Matsumoto, Y. Takahashi, M. Mochizuki, A. Seino, Y. Iwai, and S. Ōmura: Characterization of actinomycetes isolated from fallen leaves. Actinomycetologica, 12, 46-48 (1998).

702) H. Tomoda, N. Tabata, R. Masuma, S.-Y. Si, and S. Ōmura: Erabulenols, inhibitors of cholesteryl ester transfer protein produced by Penicillium sp. FO-5637. I. Production, isolation and biological properties. J. Antibiot., 51, 618-623 (1998).

703) N. Tabata, H. Tomoda, and S. Ōmura: Erabulenols, inhibitors of cholesteryl ester transfer protein produced by Penicillium sp. FO-5637. II. Structure elucidation of erabulenols A and B. J. Antibiot., 51, 624-628 (1998).

704) C. Salvat, I. Jariel-Encontre, C. Acquaviva, S. Ōmura, and M. Piechaczyk: Differential directing of c-Fos and c-Jun proteins to the proteasome in serum-stimulated mouse embryo fibroblasts. Oncogene 17, 327-337 (1998).

705) K. Matsuzaki, H. Tahara, J. Inokoshi, H. Tanaka, R. Masuma, and S. Ōmura: New brominated and halogen-less derivatives and structure-activity relationship of azaphilones inhibiting gp120-CD4 binding. J. Antibiot., 51, 1004-1011 (1998).

706) T. Tanaka, A. Mizumoto, E. Mochiki, H. Suzuki, Z. Itoh, and S. Ōmura: Effects of EM574 and cisapride on gastric contractile and emptying activity in normal and drug-induced gastroparesis in dogs. J. Pharmacol. Exp. Ther., 287, 712-719 (1998).

707) I. Namatame, H. Tomoda, S. Si, Y. Yamaguchi, R.Masuma, and S. Ōmura: Beauveriolides, specific inhibitors of lipid droplet formation in mouse macrophage, produced by Beauveria sp. FO-6979. J. Antibiot., 52, 1-6 (1999).

708) I. Namatame, H. Tomoda, N. Tabata. S. Si, and S. Ōmura: Structure elucidation of fungal beauveriolide III, a novel inhibitor of lipid droplet formation in mouse macrophages. J. Antibiot., 52, 7-12 (1999).

709) H. Zhang, H. Tomoda, N. Tabata, M. Oohori, M. Shinose, Y. Takahashi, and S. Ōmura: Zelkovamycin, a new cyclic peptide antibiotic from Streptomyces sp. K96-0670. I. Production, isolation and biological properties. J. Antibiot., 52, 29-33 (1999).

710) N. Tabata, H. Tomoda, H. Zhang, R. Uchida, and S. Ōmura: Zelkovamycin, a new cyclic peptide antibiotic from Streptomyces sp. K96-0670. II. Structure elucidation. J. Antibiot., 52, 34-39 (1999).

711) S. Ōmura, Y. Enomoto, M. Shinose, Y. Takahashi, Y. Iwai, and K. Shiomi: Isolation and structure of a new antibiotic viridomycin F produced by Streptomyces sp. K96-0188. J. Antibiot., 52, 61-64 (1999).

712) T. Sunazuka, H. Takizawa, M. Desaki, K. Suzuki, R. Obata, K. Otoguro, and S. Ōmura: Effects of erythromycin and its derivatives on interleukin-8 release by human bronchial epithelial cell line BEAS-2B cells. J. Antibiot., 52, 71-74 (1999).

713) H. Kitagawa, E. Tani, H. Ikemoto, I. Ozaki, A. Nakano, and S. Ōmura: Proteasome inhibitors induce mitochondria-independent apoptosis in human glioma cells. FEBS Letters 443, 181-186 (1999).

714) H. Tomoda, C. Matsushima, N. Tabata, I. Namatame, H. Tanaka, M. J. Bamberger, H. Arai, M. Fukuzawa, K. Inoue, and S. Ōmura: Structure-specific inhibition of cholesteryl ester transfer protein by azaphilones. J. Antibiot., 52, 160-170 (1999).

715) J. Inokoshi, M. Katagiri, S. Arima, H. Tanaka, M. Hayashi, Y.B. Kim, R. Furumai, M. Yoshida, S. Horinouchi, and S. Ōmura: Neuronal differentiation of Neuro 2α cells by inhibitors of cell cycle progression, trichostatin A and butyrolactone I. Biochem. Biophys. Res. Commun., 256, 372-376 (1999).

716) P. Masdehors, S. Ōmura, H. M.-Beral, F. Mentz, J.-M. Cosset, J. Dumont, H. Magdelenat, and J. Delic: Increased sensitivity of CLL-derived lymphocytes to apoptotic death activation by the proteasome-specific inhibitor lactacystin. British J. of Haematology, 105, 752-757 (1999).

717) R. Uchida, H. Tomoda, Y. Dong, and S. Ōmura: Altenusin, a specific neutral sphingomyelinase inhibitor, produced by Penicillium sp. FO-7436. J. Antibiot., 52, 572-574 (1999).

718) S. Ōmura, H. Tomoda, N. Tabata, Y. Ohyama, T. Abe, and M. Namikoshi: Roselipins, novel fungal metabolites having a highly methylated fatty acid modified with a mannose and an arabinitol. J. Antibiot., 52, 586-589 (1999).

719) H. Sonoda, K. Omi, K. Hojo, K. Nishida, S. Ōmura, and K. Sugita: Suppression of oncogenic transformation by hypothemycin associated with accelerated cyclin D1 degradation through ubiquitin-proteasome pathway. Life Sciences, 65, 381-394 (1999).

720) I. Namatame, H. Tomoda, H. Arai, K. Inoue, and S. Ōmura: Complete inhibition of mouse macrophage-derived foam cell formation by triacsin C. J. Biochem., 125, 319-327 (1999).

721) Y. Takahashi, A. Seino, Y. Iwai, and S. Ōmura: Taxonomic study and morphological differentiation of an actinomycete genus, Kitasatospora. (Review article). Zent. bl. Bakteriol., 289, 265-284 (1999).

722) H. Ikeda, T. Nonomiya, M. Usami, T. Ohta, and S. Ōmura: Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis. Proc. Natl. Acad. Sci., USA, 96, 9509-9514 (1999).

723) T. Tanaka, A. Mizumoto, E. Mochiki, H. Suzuki, Z. Itoh, and S. Ōmura: Effect of EM574 on postprandial pancreaticobiliary secretion, gastric motor activity, and emptying in conscious dogs. Digestive Diseases and Sci., 44, 1100-1106 (1999).

724) H. Tomoda, Y. Ohyama, T. Abe, N. Tabata, M. Namikoshi, Y. Yamaguchi, R. Masuma, and S. Ōmura: Roselipins, inhibitor of diacylglycerol KF-1040. J. Antibiot., 52, 689-694 (1999).

725) T. Matsumoto, A. Ishiyama, Y. Yamaguchi, R. Masuma, H. Ui, K. Shiomi, H. Yamada, and S. Omura: Novel cyclopentanone derivatives pentenocins A and B, with interleukin–1b converting enzyme inhibitory activity, produced by Trichoderma hamatum FO-6903. J. Antibiot., 52, 754-757 (1999).

726) K. Shiomi, H. Tomoda, K. Otoguro, and S. Ōmura: Meroterpenoids with various biological activities produced by fungi (Review article). Pure Appl. Chem., 71, 1059-1064 (1999).

727) N. Tabata, Y. Ohyama, H. Tomoda, T. Abe, M. Namikoshi, and S. Ōmura: Structure elucidation of roselipins, inhibitors of diacylglycerol acyl-transferase produced by Gliocladium roseum KF-1040. J. Antibiot., 52, 815-826 (1999).

728) H. Tomoda, I. Namatame, S. Si, K. Kawaguchi. R. Masuma, M. Namikoshi, and S. Ōmura: Phenochalasins, inhibitors of lipid droplet formation in mouse macro-phages, produced by Phomopsis sp. FT-0211. J. Antibiotics, 52, 851-856 (1999).

729) H. Tomoda, I. Namatame, N. Tabata, K. Kawaguchi, S. Si, and S. Ōmura: Structure elucidation of fungal phenochalasins, novel inhibitors of lipid droplet formation in mouse macrophages. J. Antibiot., 52, 857-861 (1999).

730) Y. Tanaka, K. Kamei, K. Otoguro, and S. Ōmura: Heme-dependent radical generation: Possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol. J. Antibiotics, 52, 880-888 (1999).

731) N. Tabata, H. Tomoda, Y. Yamaguchi, R. Masuma, M. J. Bamberger, and S. Ōmura: Inhibition of cholesteryl ester transfer protein by fungal metabolites, L681,512. J. Antibiotics, 52, 1042-1045 (1999).

732) J. Inokoshi, K. Shiomi, R. Masuma, H. Tanaka, and S. Ōmura: Funalenone, a novel collagenase inhibitor produced by Aspergillus niger. J. Antibiotics, 52, 1095-1100 (1999).

733) H. Tomoda, N. Tabata, M. Shinose, Y. Takahashi, H. Boyd Woodruff and S. Ōmura: Ferroverdins, inhibitors of cholesteryl ester transfer protein produced by Streptomyces sp. WK-5344. I. Production, isolation and biological properties. J. Antibiotics, 52, 1101-1107 (1999).

734) N. Tabata, H. Tomoda, and S. Ōmura. Ferroverdins, inhibitors of cholesteryl ester transfer protein produced by Streptomyces sp. WK-5344. II. Structure elucidation. J. Antibiotics, 52, 1108-1113 (1999).

735) S.-I. Kumeda, A. Deguchi, M. Toi, S. Ōmura, and K. Umezawa: Induction of Gl arrest and selective growth inhibition by lactacystin in human umbilical vein endothelial cells. Anticancer Res., 19, 3961-3968 (1999).

736) S. Ōmura: Antiinfective drugs into the 21st century (Review Article, in Japanese). Japanese J. Bacteriol, 54, 795-813 (1999).

737) H. Tomoda, N. Ohbayashi, H. Kumagai, H. Hashizume, T. Sunazuka, and S. Ōmura: Differential inhibition of HMG-CoA synthase and pancreatic lipase by the specific chiral isomers of β-lactone DU-6622. Biochem. Biophys. Res. Comm., 265, 536-540 (1999).

738) K. Nakatani, T. Murayama, Y. Satoh, K. Furukawa, S. Ōmura, and Y. Ohizumi: Modulation of actomyosin ATPase by thiotetromycin is mediated through conformational change of actin. Eur. J. Pharmacol., 383, 381-386 (1999).

739) N. Mugita, Y. Konda, H. Nakamura, T. Fujiwara, K. Tanaka, S. Ōmura, N. Shimbara, M. Ogawa, H. Saya, and M. Naka: The involvement of proteasome in myogenic differentiation of murine myocytes and human rhabdomyosarcoma cells. Int. J. Mol. Med., 3, 127-137 (1999).