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Discovery, chemistry, and chemical biology of microbial products [abstract]
Splendid gifts: Fifth edition
Splendid gifts from microorganisms - the achievements of Satoshi Omura and collaborators. [how to order]
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Publications: 1985-1989
304) K. Tsuzuki, M. Akeyoshi, and S. Ōmura: Sulfur-extrusive rearrangement of a-acylthio ester by lithium amide. Bull. Chem. Soc. Jpn., 58, 395-396 (1985).
305) S. Ōmura and H. Tanaka: Production and antimicrobial activity of macrolides (Review article). In "Macrolide Antibiotics" (Ed. S. Ōmura) 3-35, Academic Press (1984).
306) A. Nakagawa and S. Ōmura: Structure and stereochemistry of macrolides (Review article). In "Macrolide Antibiotics" (Ed. S. Omura) 37-84, Academic Press (1984).
307) S. Ōmura and Y. Tanaka: Biochemistry, regulation, and genetics of macrolide production (Review article). In "Macrolide Antibiotics" (Ed. S. Omura) 199-229, Academic Press (1984).
308) S. Ōmura and H. Tanaka: Production, structure, and antifungal activity of polyene macrolides (Review article). In "Macrolide Antibiotics" (Ed. S. Omura) 351-404 , Academic Press (1984).
309) S. Ōmura: Production, structure, and biological properties of macrolide-like antibiotics (Review article). In "Macrolide Antibiotics" (Ed. S. Omura) 509-552, Academic Press (1984).
310) Y. Iwai and S. Ōmura: Taxonomic properties of the genus Kitasatosporia (Review article). Actinomycetol., No. 45, 12-19 (1984).
311) H. Sano, H. Tanaka, K. Yamashita, R. Okachi, and S. Ōmura: Chemical modification of spiramycins. V. Synthesis and antibacterial activity of 3'- or 4"'-de-N-methylspiramycin I and their N-substituted derivatives. J. Antibiot., 38, 186-196 (1985).
312) S. Ōmura and H. Tomoda: Antibiotic cerulenin, its action mechanism in fatty acid synthetase and application as an inhibitor to polyketide biosynthesis. Oil Chem., 34, 2-9 (1985).
313) Y. Takahashi, Y. Iwai, and S. Ōmura: Two new species of the genus Kitasatosporia, Kitasatosporia phosalacinea sp. nov. and Kitasatosporia griseola sp. nov. J. Gen. Appl. Microbiol., 30, 377-387 (1984).
314) H. Takeshima, J. Inokoshi, M. Namiki, J. Shimada, and S. Ōmura: Structural analysis of the gene coding for hepatitis B virus surface antigen and its product. J. Gen. Virol., 66, 195-200 (1985).
315) S. Ōmura and Y. Tanaka: Control of ammonium ion level in antibiotic fermentation (Review article). In "Biological Biochemical, and Biomedical Aspects of Actinomycetes" (Eds. L. O.-Ortiz, L. F. Bojalil, and V. Yakoleff) 367-380, Academic Press (1985).
316) D. A. Hopwood, F. Malphartida, H. M. Kieser, H. Ikeda, J. Duncan, I. Fujii, B. A. M. Rudd, H. G. Floss, and S. Ōmura: Production of 'hybrid' antibiotics by genetic engineering. Nature, 314, 642-644 (1985).
317) S. Ōmura, A. Nakagawa, N. Imamura, K. Kushida, C.-M. Liu, L. H. Sello, and J. W. Westley. Structure of a new macrolide antibiotic, X-4952B. J. Antibiot., 38, 674-676 (1985).
318) H. Yamada, K. Ohtani, H. Kiyohara, J.-C. Cyong, Y. Otsuka, Y. Ueno, and S. Ōmura: Purification and chemical properties of anti-complementary polysaccharide from the leaves of Altemisia princeps. Planta Medica, 1985, 121-126.
319) Y. Iwai, H. Shimizu, and S. Ōmura: A view of the screening for antiviral antibiotics (Review article). Kagaku to Seibutsu, 23, 379-385 (1985).
320) S. Ōmura, H. Sano, and T. Sunazuka: Structure-activity relationships of spiramycins. J. Amtimicrob. Chemother., 16, Suppl. A, 1-11 (1985).
321) S. Ōmura, Y. Takahashi, Y. Iwai, and H. Tanaka: Revised nomenclature of Kitasatosporia setalba. Int. J. System. Bacteriol., 35, 221 (1985).
322) H. Tanaka, I. Moriguchi, S. Hirono, and S. Ōmura: Quantitative structure-activity relationships of O-acyl derivatives of leucomycin for antimicrobial and ribosome-binding activities. Chem. Pharm. Bull., 33, 2803-2808 (1985).
323) S. Ōmura, N. Imamura, H. Kuga, H. Ishikawa, Y. Yamazaki, K. Okano, K. Kimura, Y. Takahashi, and H. Tanaka: Adechlorin, a new adenosine deaminase inhibitor containing chlorine. Production, isolation and properties. J. Antibiot., 38, 1008-1015 (1985).
324) T. Tsuge, S. Nishimura, S. Ōmura, K. Kohmoto, and H. Otani: Metabolic regulation of host-specific toxin production in Alternaria alternata pathogens (2). Suppression of toxin production from germinating spores by chemical treatment. Ann. Phytopath. Soc. Jpn., 51, 277-284 (1985).
325) N. Imamura, M. Murata, T. Yao, R. Oiwa, H. Tanaka, and S. Ōmura: Occurrence of 1,2,4-triazole ring in actinomycetes. J. Antibiot., 38, 1110-1111 (1985).
326) S. Ōmura, M. Murata, K. Kimura, S. Matsukura, T. Nishihara, and H. Tanaka: Screening for new antifolates of microbial origin and a new antifolate AM-8402. J. Antibiot., 38, 1016-1024 (1985).
327) M. Murata, T. Miyasaka, H. Tanaka, and S. Ōmura: Diazaquinomycin A, a new antifolate antibiotic, inhibits thymidylate synthase. J. Antibiotics, 38, 1025-1033 (1985).
328) A. Nakagawa, H. Tomoda, M. V. Hao, K. Okano, Y. Iwai, and S. Ōmura: Antiviral activities of pentalenolactones. J. Antibiot., 38, 1114-1115 (1985).
329) A. Nakagawa, Y. Tanaka, K. Otoguro, and S. Ōmura: A new antifungal antibiotic, 3'-O-decarbamoylirumamycin. J. Antibiot., 38, 1266-1269 (1985).
330) S. Ōmura, R. Iwata, Y. Iwai, S. Taga, Y. Tanaka, & H. Tomoda: Luminamicin, a new antibiotic. Production, isolation and physicochemical and biological properties. J. Antibiot., 38, 1322-1326 (1985).
331) H. Sano, T. Sunazuka, H. Tanaka, K. Yamashita, R. Okachi, and S. Ōmura: Chemical modification of spiramycins. VI. synthesis and antibacterial activities of 3,3"-di-O-acyl-4"-O-sulfonyl and 3,3"-di-O-acyl-4"-O-alkyl derivatives of spiramycin I. J. Antibiot., 38, 1350-1358 (1985).
332) S. Ōmura, K. Tsuzuki, Y. Iwai, M. Kishi, S. Watanabe, and H. Shimizu: Anticoccidial activity of frenolicin B and its derivatives. J. Antibiot., 38, 1447-1448 (1985).
333) S. Ōmura, K. Tsuzuki, T. Sunazuka, H. Toyota, I. Takahashi, and Z. Itoh: Gastrointestinal motor-stimulating activity of macrolide antibiotics and the structure-activity relationship. J. Antibiot., 38, 1631-1632 (1985).
334) A. Nakagawa, T.-S. Wu, P. J. Keller, J. P. Lee, S. Ōmura, and H. G. Floss: Biosynthesis of asukamycin. Formation of the 2-amino-3-hydroxycyclopent-2-enone moiety. J. Chem. Soc., Chem. Commun., 1985, 519-521 (1985).
335) J. M. Beale, J. P. Lee, A. Nakagawa, S. Ōmura, and H. G. Floss: Biosynthesis of the antibiotic reductinomycin. J. Am. Chem. Soc., 108, 331-332 (1986).
336) S. Ōmura, H. Tanaka, H. Kuga, and N. Imamura: Adecypenol, a unique adenosine deaminase inhibitor containing homopurine and cyclopentaene rings. J. Antibiot., 39, 309-310 (1986).
337) S. Ōmura and Y. Tanaka: Biosynthesis of tylosin and its regulation by ammonium and phosphate (Review article). In "Regulation of Secondary Metabolite Formation" (Eds. H. Kleinkauf, H. V. Dohren, and H. Dornauer) 306-332, VCH Verlagsgesellschaft GmbH (1985).
338) K. Shibata, S. Satsumabayashi, H. Sano, K. Komiyama, A. Nakagawa, and S. Ōmura: Chemical modification of herbimycin A. Synthesis and in vivo antitumor activities of halogenated and other related derivatives of herbimycin A. J. Antibiot., 39, 415-423 (1986).
339) Y. Tanaka, A. Taki, R. Masuma, and S. Ōmura: Mechanism of nitrogen regulation of protylonolide biosynthesis in Streptomyces fradiae. J. Antibiot., 39, 813-821 (1986).
340) S. Ōmura, H. Ikeda, F. Marpartida, H. M. Kieser, and D. A. Hopwood: Production of new hybrid antibiotics, mederrhodins A and B, by a genetically engineered strain. Antimicrob. Agents Chemother., 29, 13-19 (1986).
341) S. Ōmura, M. Murata, K. Kimura, T. Nishihara, and H. Tanaka: Screening for new antifolates of microbial origin. In "Recent Advances in Chemotherapy, Proceedings of the 14th Int. Cong. Chemother." (Ed. J. Ishigami) 327-328, University of Tokyo Press (1985).
342) S. Ōmura and Y. Tanaka: Macrolide Antibiotics (Review article). In "Bacteriology" (Eds. H.-J. Rehm and G. Reed) 4, 360-391, VCH Verlagsgesellschaft (1986).
343) S. Ōmura, N. Imamura, K. Kawakita, Y. Mori, Y. Yamazaki, R. Masuma, Y. Takahashi, H. Tanaka, L.-Y. Huang & H. B. Woodruff: Ahpatinins, new acid proteases inhibitors containing 4-amino-3-hydroxy-5-phenylpentanoic acid. J. Antibiot., 39, 1079-1085 (1986).
344) S. Ōmura, A. Nakagawa, N. Fukamachi, K. Otoguro, and B. Kobayashi: Aggreceride, a new platelet aggregation inhibitor from Streptomyces. J. Antibiot., 39, 1180-1181 (1986).
345) Y. Kawahata, S. Takatsuto, N. Ikekawa, M. Murata, and S. Ōmura: Synthesis of a new amino acid-antibiotic, oxetin and its three stereoisomers. Chem. Pharm. Bull., 34, 3102-3110 (1986).
346) H. Tomoda, R. Iwata, Y. Takahashi, Y. Iwai, R. Oiwa, and S. Ōmura: Lustromycin, a new antibiotic produced by Streptomyces sp. J. Antibiot., 39, 1205-1210 (1986).
347) S. Ōmura, H. Tomoda, Q. M. Xu, Y. Takahashi, and Y. Iwai: Triacsins, new inhibitors of acyl-CoA synthetase produced by Streptomyces. J. Antibiot., 39, 1211-1218 (1986).
348) S. Ōmura, H. Ishikawa, H. Kuga, N. Imamura, S. Taga, Y. Takahashi, and H. Tanaka: Adecypenol, a unique adenosine deaminase inhibitor containing homopurine and cyclopentene rings. Taxonomy, production and enzyme inhibition. J. Antibiot., 39, 1219-1224 (1986).
349) K. Tsuzuki, Y. Iwai, S. Ōmura, H. Shimizu, and N. Kitajima: Nanaomycins production by a frenolicin B producing strain. J. Antibiot., 39, 1343-1345 (1986).
350) S. Ōmura, A. Nakagawa, K. Kushida, and G. Lukacs: Structure of cervinomycin, a novel antianaerobic antibiotic. J. Am. Chem. Soc., 108, 6088-6089 (1986).
351) S. Ōmura, N. Imamura, R. Oiwa, H. Kuga, R. Iwata, R. Masuma, and Y. Iwai: Clostomicins, new antibiotics produced by Micromonospora echinospora subsp. armeniaca subsp. nov. I. Production, isolation, and physicochemical and biological properties. J. Antibiot., 39, 1407-1412 (1986).
352) Y. Takahashi, Y. Iwai, and S. Ōmura: Clostomicins, new antibiotics produced by Micromonospora echinospora subsp. armeniaca subsp. nov. II. Taxonomic study of the producing microorganism. J. Antibiot., 39, 1413-1418 (1986).
353) S. Ōmura: Philosophy of new drug discovery (Review article). Microbiol. Rev., 50, 259-379 (1986).
354) H. Yamada, Y. Otsuka, and S. Omura: Structural characterization of anti-complementary polysaccharides from the leaves of Artemisia princeps. Planta Medica, 1986, 311-314.
355) R. Masuma, Y. Tanaka, H. Tanaka, and S. Ōmura: Production of nanaomycin and other antibiotics by phosphate-depressed fermentation using phosphate-trapping agents. J. Antibiot., 39, 1557-1564 (1986).
356) K. Shibata, S. Satsumabayashi, A. Nakagawa, and S. Ōmura: The structure and cytocidal activity of herbimycin C. J. Antibiot., 39, 1630-1633 (1986).
357) A. Nakagawa, Y. Iwai, H. Shimizu, and S. Ōmura: Enhanced antimicrobial activity of acetyl derivatives of cervinomycin. J. Antibiot., 39, 1636-1638 (1986).
358) S. Ōmura: Studies on macrolide and new antibiotics (Review article). Yakugaku Zasshi, 106, 729-757 (1986).
359) M. Di Giambattista, P. Vannuffel, T. Sunazuka, J. Jacob, S. Ōmura, and C. Cocito: Antagonistic interactions of macrolides and synergimycins on bacterial ribosomes. J. Am. Chemother., 18, 307-315 (1986).
360) P. S.-Nakagawa, Y. Fukushi, K. Maebashi, N. Imamura, Y. Takahashi, Y. Tanaka, H. Tanaka, and S. Ōmura: Izupeptins A and B, new glycopeptide antibiotics produced by an actinomycete. J. Antibiot., 39, 1719-1723 (1986).
361) K. Tsuzuki, H. Matsubara, A. Nakagawa, and S. Ōmura: Syntheses and antimicrobial activities of 9-O-acyl derivatives of tylosin and demycarosyl-tylosin. J. Antibiot., 39, 1784-1787 (1986).
362) Y. Tanaka, K. Hirata, Y. Takahashi, Y. Iwai, and S. Ōmura: Globopeptin, a new antifungal peptide antibiotic. J. Antibiot., 40, 242-244 (1987).
363) M. Murata, H. Tanaka, and S. Omura: 7-Hydro-8-methyl pteroylglutamyl-glutamic acid, a new anti-folate from an actinomycete. Fermentation, isolation, structure and biological activity. J. Antibiot., 40, 251-257 (1987).
364) A. Nakagawa, S. Ōmura, K. Kushida, H. Shimizu, and G. Lukacs: Structure of cervinomycin, a novel xanthone antibiotic active against anaerobe and mycoplasma. J. Antibiot., 40, 301-308 (1987).
365) S. Ōmura, K. Otoguro, N. Imamura, H. Kuga, Y. Takahashi, R. Masuma, Y. Tanaka, and H. Tanaka: Jietacins A and B, new nematocidal antibiotics from a Streptomyces sp. Taxonomy, isolation, and physico-chemical and biological properties. J. Antibiot., 40, 623-629 (1987).
366) S. Ōmura, H. Tomoda, H. Kumagai, M. D. Greenspan, J. B. Yodkovitz, J. S. Chen, A. W. Alberts, I. Martin, S., Mochales, R. L. Monaghan, J. C. Chabala, R. E. Schwartz, and A. A. Patchett. Potent inhibitory effect of antibiotic 1233A on cholesterol biosynthesis which specifically blocks 3-hydroxy-3-methyl-glutaryl coenzyme A synthase. J. Antibiot., 40, 1365-1367 (1987).
367) S. Ōmura and M. Murata: Antimetabolites from microorganisms (Review article). Radioisotopes, 36, 63 (1987).
368) T. Teshima, M. Nishikawa, I. Kubota, T. Shiba, and S. Ōmura: Structure of an antibiotic, AM-2504. In "Peptide Chemistry 1986" (Ed. T. Miyazawa) 169-174, Protein Research Foundation, Osaka (1987).
369) A. Nakagawa, N. Fukamachi, K. Yamaki, M. Hayashi, S. Oh-ishi, B. Kobayashi, and S. Ōmura: Inhibition of platelet aggregation by medermycin and its related isochromanequinone antibiotics. J. Antibiot., 40, 1075-1076 (1987).
370) Y. Takahashi and S. Ōmura: Kitasatosporia, a genus of the order Actinomycetales. The Kitasato Arch. Exp. Med., 60, 1-14 (1987).
371) S. Taga, Y. Takahashi, Y. Iwai, and S. Ōmura: Taxonomic study of luminamicin-producing actinomycete strain OMR-59. The Kitasato Arch. Exp. Med., 60, 15-24 (1987).
372) H. Tomoda, K. Igarashi, Y. Tanaka, S. Ōmura, H. Funabashi, and S. Okuda: Biosynthetic preparation of labeled cerulenin with high specific radioactivity. J. Antibiot., 40, 1457-1460 (1987).
373) S. Ōmura, K. Tsuzuki, T. Sunazuka, S. Marui, H. Toyoda, N. Inatomi, and Z. Itoh: Macrolides with gastrointestinal motor stimulating activity. J. Med. Chem., 30, 1941-1943 (1987).
374) H. Tomoda, K. Igarashi, and S. Ōmura: Inhibition of acyl-CoA synthetase by triacsins. Biochim. Biophys. Acta, 921, 595-598 (1987).
375) S. Ōmura, A. Nakagawa, T. Fujimoto, K. Saito, K. Otoguro, and J. C. Walsh: Hygromycin A, an antitreponemal substance. I. Screening method and therapeutic effect for Treponema hyodysenteriae caused infection in CF-1 mice. J. Antibiot., 40, 1619-1626 (1987).
376) A. Nakagawa, T. Fujimoto, S. Ōmura, J. C. Walsh, R. L. Stotosh, and B. George: Hygromycin A, an antitreponemal substance. II. Therapeutic effect for swine dysentery. J. Antibiot., 40, 1627-1635 (1987).
377) H. Tomoda, H. Kumagai, H. Tanaka, and S. Ōmura: F-244 specifically inhibits 3-hydroxy-3-methyl-glutaryl coenzyme A synthase. Biochim. Biophys. Acta, 922, 351-356 (1987).
378) K. Komiyama, Y. Hirokawa, H. Yamaguchi, S. Funayama, K. Masuda, Y. Anraku, I. Umezawa, and S. Ōmura: Antitumor activity of trienomycin A on murine tumors. J. Antibiot., 40, 1768-1772 (1987).
379) R. Masuma, K. Okuyama, Y. Tanaka, R. Hirose, H. Tomoda, Y. Iwai, and S. Ōmura: A new agar medium suitable for screening of anticlostridium agents. J. Antibiot., 40, 1773-1775 (1987).
380) H. Yamada, M. Yoshino, T. Matsumoto, T. Nagai, H. Kiyohara, J.-C. Cyong, A. Nakagawa, H. Tanaka, and S. Ōmura: Effects of phytosterols on anti-complementary activity. Chem. Pharm. Bull., 35, 4851-4855 (1987).
381) H. Ikeda, H. Kotaki, and S. Ōmura: Genetic studies of avermectin biosynthesis in Streptomyces avermitilis. J. Bacteriol., 169, 5615-5621 (1987).
382) H. Tomoda, H. Kumagai, Y. Takahashi, Y. Tanaka, Y. Iwai, and S. Ōmura: F-244 (1233A), a specific inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A synthase: Taxonomy of producing strain, fermentation, isolation and biological properties. J. Antibiot., 41, 247-249 (1988).
383) K. Otoguro, A. Nakagawa, and S. Ōmura: Setamycin, a 16-membered macrolide antibiotic identification and nematocidal activity. J. Antibiot., 41, 250-252 (1988).
384) Y. Tanaka, K. Kimura, Y. Komagata, K. Tsuzuki, H. Tomoda, and S. Ōmura: Radioimmuno-assay for erythromycin derivatives. J. Antibiot., 41, 258-260 (1988).
385) Y. Konda, A. Nakagawa, Y. Harigaya, M. Onda, R. Masuma, and S. Ōmura: Aurantinin B, a new antimicrobial antibiotic from bacterial origin. J. Antibiot., 41, 268-270 (1988).
386) Y. Kondo, K. Torii, S. Ōmura, and Z. Itoh: Erythromycin and its derivatives with motilin-like biological activities inhibit the specific binding of 125I-motilin to duodenal muscle. Biochem. Biophys. Res. Commun., 150, 877-882 (1988).
387) Y. Takahashi, Y. Tanaka, Y. Iwai, and S. Ōmura: Promicromonospora sukumoe sp. nov., a new species of the Actinomycetales. J. Gen. Appl. Microbiol., 33, 507-519 (1987).
388) H. Ikeda, H. Kotaki, H. Tanaka, and S. Ōmura: Involvement of glucose catabolism in avermectin production by Streptomyces avermitilis. Antimicrob. Agents Chemother., 32, 282-284 (1988).
389) K. Otoguro, R. Oiwa, Y. Iwai, H. Tanaka, and S. Ōmura: Screening for new antitrichomonas substances of microbial origin and antitrichomonal activity of trichostatin A. J. Antibiot., 41, 461-468 (1988).
390) K. Otoguro, Z.-X. Liu, K. Fukuda, Y. Li, Y. Iwai, H. Tanaka, and S. Ōmura: Screening for new nematocidal substances of microbial origin by a new method using the pine wood nematode. J. Antibiot., 41, 573-575 (1988).
391) K. Shibata, S. Satsumabayashi, H. Sano, K. Komiyama, A. Nakagawa, and S. Ōmura: Chemical modification of hitachimycin. Synthesis, antimicrobial, cytocidal and in vivo antitumor activities of hitachimycin derivatives. J. Antibiot., 41, 614-623 (1988).
392) T. Teshima, M. Nishikawa, I. Kubota, T. Shiba, Y. Iwai, and S. Ōmura: The structure of an antibiotic, dityromycin. Tetrahedron Lett., 29, 1963-1966 (1988).
393) S. Ōmura and A. Nakagawa: Antibiotics-structure elucidation and production of new substances using biosynthetic means (Review article). J. Syn. Org. Chem., Jpn., 46, 490-500 (1988).
394) H. Iwase, I. Ishii, K. Ishihara, Y. Tanaka, S. Ōmura, and K. Hotta: Release of oligosaccharides possessing reducing-endo-N-acetyl-galactosamine from mucus glycoprotein in Streptomyces sp. OH-11242 culture medium through action of endo-type of glycosidase. Biochem. Biophys. Res. Commun., 151, 422-428 (1988).
395) A. Nakagawa, Y. Konda, A. Hatano, Y. Harigaya, M. Onda, and S. Ōmura: Structure and biosynthesis of novel antibiotics, aurantinins A and B produced by Bacillus aurantinus. J. Org. Chem., 53, 2660-2661 (1988).
396) S. Ōmura, A. Nakagawa, N. Fukamachi, M. Miura, Y., Takahashi, K. Komiyama, and B. Kobayashi: OM-4842, a new platelet aggregation inhibitor from Streptomyces. J. Antibiot., 41, 812-813 (1988).
397) Y. Uehara, Y. Murakami, K. Suzukake-Tsuchiya, Y. Moriya, H. Sano, K. Shibata, and S. Ōmura: Effects of herbimycin derivatives on src oncogene function in relation to antitumor activity. J. Antibiot., 41, 831-834 (1988).
398) J. M. Beale, R. E. Herrold, H. G. Floss, R. Thiericke, A. Zeeck, A. Nakagawa, and S. Ōmura: Studies on the biosynthesis of the m-C7N unit in the antibiotics manumycin and asukamycin. J. Am. Chem. Soc., 110 , 4435-4437 (1988).
399) Y. Morimoto, K. Oda, H. Shirahama, T. Matsumoto, and S. Ōmura: Assignment of absolute configuration for virantmycin and synthesis of its antipode. Chem. Lett., 909-912 (1988).
400) S. Funayama, Y. Anraku, A. Mita, Z.-B. Yang, K. Shibata, K. Komiyama, I. Umezawa, and S. Ōmura: Structure-activity relationship of a novel antitumor ansamycin antibiotic trienomycin A and related compounds. J. Antibiot., 41, 1223-1230 (1988).
401) S. Ōmura: Search for bioactive compounds from microorganisms-strategies and methods- (Review article). In "Biology of Actinomycetes '88" (Eds. Y. Okami, T. Beppu, and H. Ogawara) 26-32, Jpn. Scientific Soc. Press (1988).
402) Y. Tanaka and S. Ōmura: Regulation of biosynthesis of polyketide antibiotics (Review article). In "Biology of Actinomycetes '88" (Eds Y. Okami, T. Beppu, and H. Ogawara) 418-423, Jpn. Scientific Soc. Press (1988).
403) Z. Itoh and S. Ōmura: Effect of RU 28965, a new macrolide antibiotic, on gastrointestinal contractile activity: side-effects in the digestive tract. Chemotherapy, 36, 104-115 (1988).
404) S. Ōmura: Penicillin. (Review article) Kagakudojin, 44, 20-21 (1989).
405) S. Ōmura, H. Tomoda, K. Kimura, D.-Z. Zhen, H. Kumagai, K. Igarashi, N. Imamura, Y. Takahashi, Y. Tanaka, and Y. Iwai: Atpenins, new antifungal antibiotics produced by Penicillium sp. Production, isolation, physicochemical and biological properties. J. Antibiot., 41, 1769-1773 (1988).
406) S. Ōmura, Y. Tanaka, K. Hisatome, S. Miura, Y. Takahashi, A. Nakagawa, H. Imai, and H. B. Woodruff: Phthoramycin, a new antibiotic active against a plant pathogen, Phytophthora sp. J. Antibiot., 41, 1910-1912 (1988).
407) N. Imamura, H. Kuga, K. Otoguro, H. Tanaka, and S. Ōmura: Structures of jietacins: union a,b-unsaturated azoxy antibiotics. J. Antibiot., 42, 156-158 (1989).
408) H. Tanaka, K. Kawakita, H. Suzuki, P. Spiri-Nakagawa, and S. Ōmura: The mode of action of cervinomycin in Staphylococcus aureus. J. Antibiot., 42, 431-439 (1989).
409) H. Nomoto, S. Katsumata, K. Takahashi, S. Funayama, K. Komiyama, I. Umezawa, and S. Ōmura: Structural studies on minor components of trienomycin group antibiotics trienomycins D and E. J. Antibiot., 42, 479-481 (1989).
410) Y. Takahashi, Y. Iwai, H. Tomoda, R. Nimura, T. Kinoshita, and S. Ōmura: Optical resolution of 2,6-diaminopimelic acid stereoisomers by high performance liquid chromatography for the chemotherapy of actinomycete strains. J. Gen. Appl. Microbiol., 35, 27-32 (1989).
411) K. Shibata, S. Satsumabayashi, H. Sano, K. Komiyama, Y. Z.-Bo, A. Nakagawa, and S. Ōmura: Chemical modification of hitachimycin. II. Synthesis and antitumor activities of carbonate derivatives. J. Antibiot., 42, 718-726 (1989).
412) K. Tsuzuki, T. Yokozuka, M. Murata, H. Tanaka, and S. Ōmura: Synthesis and biological activity of analogues of diazaquinomycin A, a new thymidylate synthase inhibitor. J. Antibiot., 42, 727-737 (1989).
413) H. Takeshima, J. Inokoshi, Y. Takada, H. Tanaka, and S. Ōmura: A deacylation enzyme for aculeacin A, a neutral lipopeptide antibiotic, from Actinoplanes utahensis: Purification and characterization. J. Biochem., 105, 606-610 (1989).
414) H. Funabashi, A. Kawaguchi, H. Tomoda, S. Ōmura, S. Okuda, and S. Iwasaki: Binding site of cerulenin in fatty acid synthetase. J. Biochem., 105, 751-755 (1989).
415) H. Tanaka and S. Ōmura: New adenosine deaminase inhibitors, adechlorin and adecypenol. (Review article). In "Novel Microbial Products for Medicine and Agriculture" (Eds. A. L. Demain, G. A. Somkuti, J. C. Hunter-Cevera, and H. W. Rossmoore) 67-72, Elsevier (1989).
416) H. Tomoda and S. Ōmura: Triacsins, acyl-CoA synthetase inhibitors and F-244, a hydroxy-methylglutaryl-CoA synthase inhibitors. In "Novel Microbial Products for Medicine and Agriculture" (Eds. A. L. Demain, G. A. Somkuti, J. C. Hunter-Cevera, and H. W. Rossmoore) 171-177, Elsevier (1989).
417) E. J. Hartman, S. Ōmura, and M. Laposata: Triacsin C, a differential inhibitor of arachidonyl-CoA synthetase and nonspecific long chain acyl-CoA synthetase. Prostaglandins, 37, 655-671 (1989).
418) S. Funayama, S. Eda, K. Komiyama, S. Ōmura, and T. Tokunaga: Structure of phenazinomycin, a novel antitumor antibiotic. Tetrahedron Lett., 30, 3151-3154 (1989).
419) S. Ōmura, S. Eda, S. Funayama, K. Komiyama, Y. Takahashi, and H. Boyd Woodruff: Studies on a novel antitumor antibiotic, phenazinomycin: Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics. J. Antibiot., 42, 1037-1042 (1989).
420) K. Shibata, S. Satsumabayashi, H. Sano, K. Komiyama, Y. Zhi-Bo, A. Nakagawa, and S. Ōmura: Chemical modification of hitachimycin. III. Synthesis and antitumor activities of amino acyl derivatives. J. Antibiot., 42, 1114-1123 (1989).
421) M. Debono, K. E. Willard, H. A. Kirst, J. A. Wind, G. D. Crouse, E. V. Tao, J. T. Vicenzi, F. T. Counter, J. L. Ott, E. E. Ose, and S. Ōmura: Synthesis and antimicrobial evaluation of 20-deoxy-20-(3,5-dimethylpiperidinyl)-desmycosin (tilmicosin, EL-870) and related cyclic amino derivatives. J. Antibiot., 42, 1253-1267 (1989).
422) H. Imai, A. Nakagawa, and S. Ōmura: Biosynthesis of the antibiotics okilactomycin. J. Antibiot., 42, 1321-1323 (1989).
423) A. Nakagawa, S. Miura, H. Imai, N. Imamura, and S. Ōmura: Structure and biosynthesis of a new antifungal antibiotic, phthoramycin. J. Antibiot., 42, 1324-1327 (1989).
424) K. Komiyama, S. Funayama, Y. Anraku, A. Mita, Y. Takahashi, S. Ōmura, and H Shimasaki: Isolation of isoflavonoids possessing antioxidant activity from the fermentation broth of Streptomyces sp. J. Antibiot., 42, 1344-1349 (1989).
425) S. Funayama, Y. Anraku, A. Mita, K. Komiyama, and S. Ōmura: Structural study of isoflavonoids possessing antioxidant activity isolated from the fermentation broth of Streptomyces sp. J. Antibiot., 42, 1350-1355 (1989).
426) K. Tsuzuki, T. Sunazuka, S. Marui, H. Toyoda, S. Ōmura, N. Inatomi, and Z. Itoh: Motilides, macrolides with gastrointestinal motor stimulating activity. I. O-Substituted and tertiary N-substituted derivatives of 8,9-anhydro-erythromycin A 6,9-hemiacetal. Chem. Pharm. Bull., 37, 2687-2700 (1989).
427) T. Sunazuka, K. Tsuzuki, S. Marui, H. Toyoda, S. Ōmura, N. Inatomi, and Z. Itoh: Motilides, macrolides with gastrointestinal motor stimulating activity. II. Quaternary N-substituted derivatives of 8,9-anhydroerythromycin A 6,9-hemiacetal and 9,9-dihydroerythromycin A 6,9-epoxide. Chem. Pharm. Bull., 37, 2701-2709 (1989).
428) T. Lee, J. Inokoshi, M. Namiki, H. Takeshima, and S. Ōmura: Production of hepatitis B virus surface antigen containing pre-Sl and pre-S2 domains by chinese hamster ovary cells. Arch. Virol., 106, 151-158 (1989).
429) H. A. Kirst, K. E. Willard, M. Debono, J. E. Toth, B. A. Truedell, J. P. Leeds, J. L. Ott, A. M. Felty-Duckworth, F. T. Counter, E. E. Ose, G. D. Crouse, J. M. Tustin, and S. Ōmura: Structure-activity studies of 20-deoxo-20-amino derivatives of tylosin-related macrolides. J. Antibiot., 42, 1673-1683 (1989).
430) H. Tanaka, K. Kawakami, Z.-B. Yang, K. Komiyama, and S. Ōmura: Potentiation of cytotoxicity and antitumor activity of adenosine analogs by the adenosine deaminase inhibitor adecypenol. J. Antibiot., 42, 1722-1724 (1989).
431) S. Funayama, M. Ishibashi, Y. Anraku, M. Miyauchi, H. Mori, K. Komiyama, and S. Ōmura: Novel cytocidal antibiotics, glucopiericidinols A1 and A2. Taxonomy, fermentation, isolation, structure elucidation and biological characteristics. J. Antibiot., 42, 1734-1740 (1989).