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Discovery, chemistry, and chemical biology of microbial products [abstract]
Splendid gifts: Fifth edition
Splendid gifts from microorganisms - the achievements of Satoshi Omura and collaborators. [how to order]
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Publications: 1980-1984
177) S. Okubo, N. Nakamura, M. Morimoto, K. Mineura, H. Marumo, and S. Ōmura: Studies on antitumor activity of prumycin. II. Studies on distribution and excretion of prumycin. J. Antibiot., 33, 221-225 (1980).
178) S. Okubo, N. Nakamura, M. Morimoto, K. Mineura, H. Marumo, and S. Ōmura: Studies on antitumor activity of prumycin. III. Mode of action of prumycin on HeLa S-3 cells. J. Antibiot., 33, 226-230 (1980).
179) S. Okubo, M. Morimoto, K. Mineura, H. Marumo, and S. Ōmura: Studies on antitumor activity of prumycin. IV. Effect of prumycin on mouse immune system. J. Antibiot., 33, 231-235 (1980).
180) S. Ōmura and H. Sakakibara: Chemical modification of 14-membered macrolide antibiotics (Review article). Yuki Gosei Kagaku, 38, 395-414 (1980).
181) H. Ohno, M. Yoshida, Y. Takahashi, and S. Ōmura: Improvement of the productivity of elasnin, a specific elastase inhibitor, by Streptomyces noboritoensis KM-2753. J. Antibiot., 33, 474-479 (1980).
182) S. Ōmura: Searching for new antibiotics (Review article). Pharmacia, 16, 385-398 (1980).
183) S. Ōmura, C. Kitao, and H. Matsubara: Isolation and characterization of a new 16-membered lactone, protylonolide, from a mutant of tylosin-producing strain, Streptomyces fradiae KA-427. Chem. Pharm. Bull., 29, 1963-1965 (1980).
184) C. Kitao, H. Tanaka, S. Minami, and S. Ōmura: Bioconversion and biosynthesis of nanaomycins using cerulenin, a specific inhibitor of fatty acid and polyketide biosyntheses. J. Antibiot., 33, 711-716 (1980).
185) S. Ōmura, Y. Iwai, R. Masuma, M. Hayashi, T. Furusato, and T. Takagaki: A new peptide antibiotics, alboleutin. J. Antibiot., 33, 758-759 (1980).
186) A. Furusaki, T. Matsumoto, A. Nakagawa, and S. Ōmura: Herbimycin A: an ansamycin antibiotic; X-ray crystal structure. J. Antibiot., 33, 781-782 (1980).
187) P. Spiri-Nakagawa, R. Oiwa, Y. Tanaka, H. Tanaka, and S. Ōmura: The site of inhibition of bacterial cell wall peptidoglycan synthesis by azureomycin B, a new antibiotic. J. Biochem., 88, 565-570 (1980).
188) S. Ōmura, C. Kitao, and N. Sadakane: The microbial transformation of tylosin by the spiramycin-producing strain, Streptomyces ambofaciens KA-1028. J. Antibiot., 33, 911-912 (1980).
189) S. Ōmura, N. Sadakane, C. Kitao, H. Matsubara, and A. Nakagawa: Production of mycarosyl protylonolide by a mycaminose idiotroph from the tylosin-producing strain Streptomyces fradiae KA-427. J. Antibiot., 33, 913-914 (1980).
190) S. Ōmura, H. Matsubara, A. Nakagawa, A. Furusaki, and T. Matsumoto: X-ray crystallography of protylonolide and absolute configuration of tylosin. J. Antibiot., 33, 915-917 (1980).
191) A. Nakagawa, H. Ohno, K. Miyano, and S. Ōmura: Structure of elasnin, a novel elastase inhibitor containing an a-pyrone ring. J. Org. Chem., 45, 3268-3274 (1980).
192) A. Furusaki, T. Matsumoto, H. Ogura, H. Takayanagi, A. Hirano, and S. Ōmura: X-ray crystal structure of herquline, a new biologically active piperazine from Penicillium herquei Fg-372. J. Chem. Soc., Chem. Commun., 1980, 698 (1980).
193) Y. Iwai, A. Nakagawa, N. Sadakane, S. Ōmura, H. Oiwa, S. Matsumoto, M. Takahashi, T. Ikai, and Y. Ochiai: Herbimycin B, a new benzo-quinonoid ansamycin with anti-TMV and herbicidal activities. J. Antibiot., 33, 1114-1119 (1980).
194) Y. Konda, M. Onda, A. Hirano, and S. Ōmura: Oxaline and neoxaline. Chem. Pharm. Bull., 28, 2987-2993 (1980).
195) S. Ōmura, A. Nakagawa, H. Hashimoto, R. Oiwa, Y. Iwai, A. Hirano, N. Shibukawa, and Y. Kojima: Virantmycin, a potent antiviral antibiotic produced by a strain of Streptomyces. J. Antibiot., 33,, 1395-1396 (1980).
196) H. Marumo, K. Kitaura, M. Morimoto, H. Tanaka, and S. Ōmura: The mode of action of nanaomycin A in Gram-positive bacteria. J. Antibiot., 33, 885-890 (1980).
197) K. Kitaura, Y. Araki, H. Marumo, and S. Ōmura: The therapeutic effect of nanaomycin A against experimental Trichophyton mentagrophytes infection in guinea pigs. Jpn. J. Antibiot., 33, 728-732 (1980).
198) S. Ōmura: Biosynthetic precursors of natural products (5)--Antibiotics (Review article). Kagaku no Ryoiki, 34, 18-27 (1980).
199) S. Ōmura, Y. Tanaka, C. Kitao, H. Tanaka, and Y. Iwai: Stimulation of leucomycin production by magnesium phosphate and its relevance to nitrogen catabolite regulation. Antimicrob. Agents Chemother., 18, 691-695 (1980).
200) S. Ōmura, Y. Tanaka, H. Tanaka, Y. Takahashi, and Y. Iwai: Stimulation of the production of macrolide antibiotics by magnesium phosphate and related insoluble materials. J. Antibiot., 33, 1568-1569 (1980).
201) S. Ōmura, H. Ikeda, H. Matsubara, and N. Sadakane: Hybrid biosynthesis and absolute configuration of macrolide antibiotic M-4365G1. J. Antibiot., 33, 1570-1572 (1980).
202) K. Kakinuma, N. Imamura, N. Ikekawa, H. Tanaka, S. Minami, and S. Ōmura: Structure and biosynthesis of setomimycin. A novel 9,9'-bianthryl antibiotic. J. Am. Chem. Soc., 102, 7493-7498 (1980).
203) K. Otoguro, J. Awaya, H. Tanaka, and S. Ōmura: Saturated fatty acid-starved cells of Saccharomyces cerevisiae grown in the presence of cerulenin and oleic acid. J. Biochem., 89, 523-529 (1981).
204) F. Taguchi, Y. Imatani, D. Nagaki, A. Nakagawa, and S. Ōmura: Selective antiviral activity of the antibiotic 2'-amino-2'-deoxyribofuranosyl adenine. J. Antibiot., 34, 313-316 (1981).
205) S. Ōmura: Macrolide antibiotics (Review article). In "Antibiotics" (Ed. by H. Yonehara) 187-223, Chikyu-sha (1981).
206) S. Omura and A. Nakagawa: Biosynthesis of 16-membered macrolide antibiotics (Review article). In "Antibiotics IV, Biosynthesis" (Ed. by J. W. Corcoran) 175-192, Springer-Verlag (1981).
207) A. Nakagawa, N. Sadakane and S. Ōmura: Structure of herbimycin B. J. Chem. Soc. Jpn., Chem. & Ind. Chem., 1981, 892-894 (1981).
208) S. Ōmura, H. Ikeda, and H. Tanaka: Extraction and characterization of plasmids from macrolide antibiotic-producing streptomycetes. J. Antibiot., 34, 478-482 (1981).
209) S. Ōmura and A. Nakagawa: Structure of virantmycin, a novel antiviral antibiotic. Tetrahedron Lett., 22, 2199-2202 (1981).
210) N. Imamura, K. Kakinuma, N. Ikekawa, H. Tanaka, and S. Ōmura: Identification of the aglycon part of vineomycin A1 with aquayamycin. Chem. Pharm. Bull., 29, 1788-1790 (1981).
211) S. Ōmura, S. Minami, and H. Tanaka: Biosynthesis of nanaomycin: Syntheses of nanaomycin E from nanaomycin A and of nanaomycin B from nanaomycin E in a cell-free system. J. Biochem., 90, 291-293 (1981).
212) S. Ōmura, H. Tanaka, S. Minami, and I. Takahashi: Biosynthesis of nanaomycin. II. Purification and properties of nanaomycin D reductase involved in the formation of nanaomycin A from nanaomycin D. J. Biochem. ,90, 355-362 (1981).
213) H. Sakakibara, O. Okekawa, T. Fujiwara, M. Otani, and S. Ōmura: Acyl derivatives of 16-membered macrolides. I. Synthesis and biological properties of 3"-O-propionyl-leucomycin A5 (TMS19-Q). J. Antibiot., 34,, 1001-1010 (1981).
214) H. Sakakibara, O. Okekawa, T. Fujiwara, M. Aizawa, and S. Ōmura: Acyl derivatives of 16-membered macrolides. II. Antibacterial activities and serum levels of 3"-O-acyl derivatives of leucomycin. J. Antibiot., 34, 1011-1018 (1981).
215) Y. Konda, M. Onda, K. Hinotozawa, and S. Ōmura: Structure of antitumor alkaloid AM6201. J. Antibiot., 34, 1222-1223 (1981).
216) S. Ōmura, K. Otoguro, T. Nishikiori, R. Oiwa, and Y. Iwai: Setamycin, a new antibiotic. J. Antibiot., 34, 1253-1256 (1981).
217) S. Ōmura: Screening of specific inhibitors of cell wall peptidoglycan synthesis (Review article): An approach to early identification of new antibiotics. In "The Future of Antibiotherapy and Antibiotic Research" (Eds. by L. Ninet, P. E. Bost, D. H. Bouanchaud, and J. Florent) 389-405, Academic Press (1981).
218) A. Nakagawa, Y. Iwai, H. Hashimoto, N. Miyazaki, R. Oiwa, Y. Takahashi, A. Hirano, N. Shibukawa, Y. Kojima, and S. Ōmura: Virantmycin, a new antiviral antibiotic produced by a strain of Streptomyces. J. Antibiot., 34, 1408-1415 (1981).
219) S. Ōmura: Cerulenin (Review article). In "Methods in Enzymology" (Ed. by J. M. Lowenstein) 72, 520-532, Academic Press (1981).
220) N. Imamura, K. Kakinuma, N. Ikekawa, H. Tanaka, and S. Ōmura: The structure of vineomycin B2. J. Antibiot., 34,1517-1518 (1981).
221) Y. Tanaka, Y. Takahashi, R. Masuma, Y. Iwai, H. Tanaka, and S. Ōmura: Enhancement and cultural characteristics of leucomycin production by Streptomyces kitasatoensis in the presence of magnesium phosphate. Agricult. Biol. Chem., 45, 2475-2481 (1981).
222) Y. Tanaka, S. Ōmura, K. Araki, and K. Nakayama: Derepression of glycine decarboxylase synthesis by magnesium phosphate in Nocardia butanica. Agricult. Biol. Chem., 45, 2661-2664 (1981).
223) H. Sakakibara, T. Fujiwara, M. Aizawa, and S. Ōmura: 9-epi-Leucomycin A5. Synthesis and antimicrobial activity. J. Antibiot., 34, 1577-1580 (1981).
224) S. Ōmura, Y. Iwai, Y. Takahashi, K. Kojima, K. Otoguro, and R. Oiwa: Type of diaminopimelic acid different in aerial and vegetative mycelia of setamycin-producing actinomycete KM-6054. J. Antibiot., 34, 1633-1634 (1981).
225) Y. Tanaka, H. Tanaka, S. Ōmura, K. Araki, and K. Nakayama: Magnesium phosphates stimulate microbial conversion of glycine to L-serine by release from regulation by ammonium ions. J. Ferment. Technol., 59, 447-455 (1981).
226) S. Ōmura and R. Oiwa: Avermectin (Review article). Kagaku to Seibutsu, 20, 10-12 (1982).
227) Y. Iwai and S. Omura: Culture conditions for screening of new antibiotics. J. Antibiot., 35, 123-141 (1982).
228) S. Ōmura, Y. Tanaka, A. Nakagawa, Y. Iwai, M. Inoue, and T. Tanaka: Irumamycin, a new antibiotic active against phytopathogenic fungi. J. Antibiot., 35, 256-257 (1982).
229) H. Matsubara, K. Miyano, A. Nakagawa, and S. Ōmura: Chemical transformation of tylosin, a 16-membered macrolide, and its structure-activity relationship. Chem. Pharm. Bull., 30, 97-110 (1982).
230) S. Ōmura, N. Sadakane, and H. Matsubara: Bioconversion and biosynthesis of 16-membered macrolide, and its structure-activity relationship. Chem. Pharm. Bull., 30, 223-229 (1982).
231) Y. Tanaka, H. Tanaka, S. Ōmura, K. Araki, and N. Nakayama: Ammonia trapping and stimulation of L-serine production from glycine by magnesium phosphate. Agricult. Biol. Chem., 46, 543-545 (1982).
232) S. Ōmura, K. Miyano, H. Matsubara, and A. Nakagawa: Novel dimeric derivatives of leucomycins and tylosin, sixteen-membered macrolides. J. Med. Chem., 25, 271-275 (1982).
233) S. Ōmura and R. Oiwa. Avermectin and its derivatives (Review article). The Kitasato Medical News, 28, 1-16 (1981).
234) M. Onda, Y. Konda, K. Hinotozawa, and S. Ōmura: The alkaloid AM-6201 from Streptomyces xanthochromogenus. Chem. Pharm. Bull., 30, 1210-1214 (1982).
235) S. Ōmura and H. Tanaka: Cell-free biosynthesis of macrolides and other "polyketide" antibiotics (Review article). In "Proceeding of VIth International Fermentation Symposium and Vth International Symposium on Yeast" 77-82 (1982).
236) S. Ōmura, H. Tanaka, J. Inokoshi, H. Sakakibara, and T. Fujiwara: Binding of [3H]-tetrahydroleucomycin A3 to Escherichia coli ribosomes and the effect of 3"-O-acyl derivatives of leucomycins and on the binding. J. Antibiot., 35, 491-496 (1982).
237) H. Ikeda, H. Tanaka, and S. Ōmura: Isolation and characterization of covalently closed circular DNA associated with chromosomal and membrane fraction from Streptomyces ambofaciens. J. Antibiot., 35, 497-506 (1982).
238) H. Ikeda, H. Tanaka, and S. Ōmura: Genetic and biochemical features of spiramycin biosynthesis in Streptomyces ambofaciens — curing, protoplast regeneration and plasmid transfer. J. Antibiot., 35, 507-516 (1982).
239) N. Imamura, K. Kakinuma, N. Ikekawa, H. Tanaka, and S. Ōmura: Biosynthesis of vineomycins A1 and B2. J. Antibiot., 35, 602-608 (1982).
240) S. Ōmura, Y. Tanaka, H. Tanaka, Y. Takahashi, Y. Iwai, and C. Kitao: Stimulation of leucomycin production by magnesium phosphate and its relevance to nitrogen catabolite regulation (Review article). In "Proceeding of VIth International Fermentation Symposium and Vth International Symposium on Yeast" 181-185 (1982).
241) S. Ōmura, Y. Iwai, K. Hinotozawa, Y. Takahashi, J. Kato, and A. Nakagawa: Cervinomycin A1 and A2, new antibiotics active against anaerobes, produced by Streptomyces cervinus sp. nov. J. Antibiot., 35, 645-652 (1982).
242) N. Sadakane, Y. Tanaka, and S. Ōmura: Hybrid biosynthesis of derivatives of protylonolide and M-4365 by macrolide-producing microorganisms. J. Antibiot., 35, 680-687 (1982).
243) A. A. Jakubowski, F. S. Guziec, Jr., M. Sugiura, C. C. Tam, M. Tishler, and S. Ōmura: Total synthesis of (+)-cerulenin, (+)-tetrahydrocerulenin, and related compounds. J. Org. Chem., 47, 1221-1228 (1982).
244) A. Kawaguchi, H. Tomoda, S. Nozoe, S. Ōmura, and S. Okuda: Mechanism of action of cerulenin on fatty acid synthetase. Effect of cerulenin on iodo-acetamide-induced malonyl-CoA decarboxylase activity. J. Biochem., 92, 7-12 (1982).
245) S. Ōmura, Y. Takahashi, Y. Iwai, and H. Tanaka: Kitasatosporia, a new genus of the order Actinomycetales. J. Antibiot., 35, 1013-1019 (1982).
246) S. Ōmura, H. Tanaka, and M. Tsukui: Biosynthesis of tylosin: Oxidations of 5-O-mycaminosyl-protylonolide at C-20 and C-23 with a cell-free extract from Streptomyces fradiae. Biochem. Biophys. Res. Commun., 107, 554-560 (1982).
247) M. Hayashi, T. Unemoto, S. Minami-Kakinuma, H. Tanaka, and S. Ōmura: The mode of action of nanaomycins D and A on a Gram-positive marine bacterium Vibrio alginolyticus. J. Antibiot., 35, 1078-1085 (1982).
248) R. Masuma, Y. Tanaka, and S. Ōmura: Enhancement of cerulenin production by a natural zeolite, an ammonium ion-trapping agent. J. Antibiot., 35, 1184-1193 (1982).
249) H. Tanaka, R. Oiwa, S. Matsukura, J. Inokoshi, and S. Ōmura: Studies on bacterial cell wall inhibitors. X. Properties of phospho-N-acetylmuramoyl-pentapeptide-transferase in peptidoglycan synthesis of Bacillus megaterium and its inhibition by amphomycin. J. Antibiot., 35, 1216-1221 (1982).
250) S. Ōmura, Y. Iwai, K. Hinotozawa, H. Tanaka, Y. Takahashi, and A. Nakagawa: OM-704 A, a new antibiotic active against Gram-positive bacteria produced by Streptomyces sp. J. Antibiot., 35, 1425-1429 (1982).
251) H. Tanaka, S. Minami-Kakinuma, and S. Ōmura: Biosynthesis of nanaomycin. III. Nanaomycin A formation from nanaomycin D by nanaomycin D reductase via hydroquinone. J. Antibiot., 35, 1565-1570 (1982).
252) S. Ōmura, A. Nakagawa, K. Shibata, and H. Sano: The structure of hitachimycin, a novel macrocyclic lactam involving b-phenylalanine. Tetrahedron Lett., 23, 4713-4716 (1982).
253) S. Ōmura, A. Nakagawa, and Y. Tanaka: New macrocyclic antibiotics, irumamycin and hitachimycin (stubomycin). In "Trends in Antibiotic Research" 135-145, Jpn. Antibiot. Res. Assoc., Tokyo (1982).
254) A. Furusaki, N. Hashiba, T. Matsumoto, A. Hirano, Y. Iwai, and S. Ōmura: The crystal and molecular structure of staurosporine, an new alkaloid from a Streptomyces strain. Bull. Chem. Soc. Jpn., 55, 3681-3685 (1982).
255) S. Ōmura, H. Shimizu, Y. Iwai, K. Hinotozawa, K. Otoguro, H. Hashimoto, and A. Nakagawa: AM-2604, a new antiviral antibiotic produced by a strain of Streptomyces. J. Antibiot., 35, 1632-1637 (1982).
256) V. P. Gullo, S. B. Zimmerman, R. S. Dewey, O. Hensens, P. J. Cassidy, R. Oiwa, and S. Ōmura: Factumycin, a new antibiotic (A40A): Fermentation, isolation and antibacterial spectrum. J. Antibiot., 35, 1705-1707 (1982).
257) S. Ōmura, A. Nakagawa, and Y. Tanaka: Structure of a new antifungal antibiotic, irumamycin. J. Org. Chem., 47, 5413-5415 (1982).
258) H. Ikeda, M. Inoue, and S. Ōmura: Improvement of macrolide antibiotic-producing Streptomycete strains by the regeneration of protoplasts. J. Antibiot., 36, 283-288 (1983).
259) S. Ōmura, Y. Iwai, A. Nakagawa, R. Iwata, Y. Takahashi, H. Shimizu, and H. Tanaka: Thiotetromycin, a new antibiotic-taxonomy, production, isolation, and physicochemical and biological properties. J. Antibiot., 36, 109-114 (1983).
260) R. Oiwa, Y. Iwai, Y. Takahashi, K. Kitao, and S. Ōmura: Taxonomic studies of a stubomycin (hitachimycin)-producing actinomycete. The Kitasato Arch. Exp. Med., 55, 119-124 (1982).
261) S. Ōmura, K. Tsuzuki, A. Nakagawa, and G. Lukacs: Biosynthetic origin of carbons 3 and 4 of leucomycin aglycone. J. Antibiot., 36, 611-613 (1983).
262) S. Ōmura, K. Tsuzuki, Y. Tanaka, H. Sakakibara, M. Aizawa, and G. Lukacs: Valine as a precursor of the n-butyrate unit in the biosynthesis of macrolide aglycone. J. Antibiot., 36, 614-616 (1983).
263) N. Sadakane, Y. Tanaka, and S. Ōmura: Hybrid biosynthesis of a new macrolide antibiotics by a daunomycin-producing microorganisms. J. Antibiot., 36, 921-922 (1983).
264) S. Ōmura, N. Sadakane, Y. Tanaka, and H. Matsubara: Chimeramycins: new macrolide antibiotics produced by hybrid biosynthesis. J. Antibiot., 36, 927-930 (1983).
265) N. Sadakane, Y. Tanaka, and S. Ōmura: New 20-membered lactones, irumanolides I and II, produced by a mutant of Streptomyces. J. Antibiot., 36, 931-933 (1983).
266) H. Funabashi, S. Iwasaki, S. Okuda, and S. Ōmura: A model study on the mechanism of fatty acid synthetase inhibition by antibiotic cerulenin. Tetrahedron Lett., 24, 2673-2676 (1983).
267) S. Ōmura, A. Nakagawa, H. Aoyama, K. Hinotozawa, and H. Sano: The structure of diazaquinomycins A and B, new antibiotic metabolites. Tetrahedron Lett., 24, 3643-3646 (1983).
268) S. Ōmura, A. Nakagawa, H. Aoyama, and Y. Iwai: Karabemycin, a new antimetabolite of glutamine produced by a strain of streptomycete. J. Antibiot., 36, 1129-1135 (1983).
269) H. Sano, M. Inoue, K. Yamashita, R. Okachi, and S. Ōmura: Chemical modification of spiramycins. I. Synthesis of the acetal derivatives of neospiramycin I. J. Antibiot., 36, 1336-1344 (1983).
270) Y. Iwai, K. Kimura, Y. Takahashi, K. Hinotozawa, H. Shimizu, H. Tanaka, and S. Ōmura: OM-173, new nanaomycin-type antibiotics produced by a strain of Streptomyces. Taxonomy, production, isolation and biological properties. J. Antibiot., 36, 1268-1274 (1983).
271) N. Enoki, K. Tsuzuki, S. Ōmura, R. Ishida, and T. Matsumoto: New antimicrobial diterpenes, dictyol F and epidictyol F, from the brown alga Dictyota dichotoma. Chem. Lett., 1627-1630 (1983).
272) M. Onda, Y. Konda, A. Hatano, T. Hata, and S. Ōmura: Structure of carzinophilin. 3. Structure elucidation by nuclear magnetic resonance spectroscopy. J. Am. Chem. Soc., 105, 6311-6312 (1983).
273) K. Tsuzuki and S. Ōmura: Syntheses and biological activities of thiotetromycin analogs. J. Antibiot., 36, 1589-1591 (1983).
274) S. Ōmura, J. Inokoshi, H. Matsubara, and H. Tanaka: Ribosome-binding activities and antimicrobial activities of tylosin and its related compounds. J. Antibiotics, 36, 1709-1712 (1983).
275) H. Matsubara, J. Inokoshi, A. Nakagawa, H. Tanaka, and S. Ōmura: Chemical modification of tylosin: synthesis of amino derivatives at C-20 position of tylosin and demycarosyltylosin. J. Antibiot., 36, 1713-1721 (1983).
276) S. Ōmura, K. Otoguro, and H. Tanaka: The mode of action of a novel 18-membered macrolide, virustomycin A (AM-2604 A), on Trichomonas foetus. J. Antibiot., 36, 1755-1761 (1983).
277) S. Ōmura, A. Nakagawa, R. Iwata, and A. Hatano: Structure of a new antibacterial antibiotic, thiotetromycin. J. Antibiot., 36, 1781-1782 (1983).
278) S. Ōmura, N. Imamura, K. Hinotozawa, K. Otoguro, G. Lukacs, R. Faghih, R. Tolmann, B. H. Arison, and J. L. Smith: The structure of virustomycin A. J. Antibiot., 36, 1783-1786 (1983).
279) S. Ōmura, Y. Tanaka, H. Mamada, and R. Masuma: Ammonium ion suppresses the biosynthesis of tylosin aglycone by interference with valine catabolism in Streptomyces fradiae. J. Antibiot., 36, 792-1794 (1983).
280) R. Masuma, Y. Tanaka, and S. Ōmura: Ammonium ion-depressed fermentation of tylosin by the use of a natural zeolite and its significance in the study of biosynthetic regulation of the antibiotic. J. Ferm. Technol., 61, 607-614 (1983).
281) S. Ōmura: Screening for bioactive substances from microorganisms (Review article). Gekkan Yakuji, 26, 27-33 (1984).
282) Y. Takahashi, Y. Iwai, and S. Ōmura: Relationship between cell morphology and the types of diaminopimelic acid in Kitasatosporia setae. J. Gen. Appl. Microbiol., 29, 459-465 (1983).
283) S. Ōmura, Y. Tanaka, H. Mamada, and R. Masuma: Effect of ammonium ion, inorganic phosphate and amino acids on the biosynthesis of protylonolide, a precursor of tylosin aglycone. J. Antibiot., 37, 494-502 (1984).
284) H. Tomoda, A. Kawaguchi, S. Ōmura, and S. Okuda: Cerulenin resistance in a cerulenin-producing fungus. II. Characterization of fatty acid synthetase from Cephalosporium caerulens. J. Biochem., 95, 1705-1712 (1984).
285) H. Tomoda, A. Kawaguchi, T. Yasuhara, T. Nakajima, S. Ōmura, and S. Okuda: Cerulenin resistance in a cerulenin-producing fungus. III. Studies on active-site peptides of fatty acid synthetase from Cephalosporium caerulens. J. Biochem., 95, 1713-1723 (1984).
286) S. Ōmura, H. Mamada, N.-J. Wang, N. Imamura, R. Oiwa, Y. Iwai, and N. Muto: Takaokamycin, a new peptide antibiotic produced by Streptomyces sp. J. Antibiot., 37, 700-705 (1984).
287) H. Sano, M. Inoue, and S. Ōmura: Chemical modification of spiramycins. II. Synthesis and antimicrobial activity of 4'-deoxy derivatives of neospiramycin I and their 12-(z)-isomers. J. Antibiot., 37, 738-749 (1984).
288) H. Sano, T. Sunazuka, H. Tanaka, K. Yamashita, R. Okachi, and S. Ōmura: Chemical modification of spiramycins. III. Synthesis and antibacterial activities of 4"-sulfonates and 4-alkylethers of spiramycin I. J. Antibiot., 37, 750-759 (1984).
289) H. Sano, T. Sunazuka, H. Tanaka, K. Yamashita, R. Okachi, and S. Ōmura: Chemical modification of spiramycins. IV. Synthesis and in vitro and in vivo activities of 3",4"-diacylates and 3,3",4"-triacylates of spiramycin I. J. Antibiot., 37, 760-772 (1984).
290) T. Kimura, K. Tsuchiya, and S. Ōmura: Prohisin, new thiol protease inhibitor produced by Cephalosporium sp. KM-388. Agricult. Biol. Chem., 48, 1685-1686 (1984).
291) S. Ōmura, M. Murata, H. Hanaki, K. Hinotozawa, R. Oiwa, and H. Tanaka: Phosalacine, a new herbicidal antibiotic containing phosphinothricin. Fermentation, isolation, biological activity and mechanism of action. J. Antibiot., 37, 829-835 (1984).
292) S. Ōmura, K. Hinotozawa, N. Imamura, and M. Murata: The structure of phosalacine, a new herbicidal antibiotic containing phosphinothricin. J. Antibiot., 37, 939-940 (1984).
293) S. Ōmura, H. Matsubara, K. Tsuzuki, and A. Nakagawa: Chemical modification of tylosin thioether derivatives of tylosin and demycarosyltylosin. J. Antibiot., 37, 1007-1015 (1984).
294) Y. Takahashi, T. Kuwana, Y. Iwai, and S. Ōmura: Some characteristics of aerial and submerged spores of Kitasatosporia setalba. J. Gen. Appl. Microbiol., 30, 223-229 (1984).
295) M. Onda, Y. Konda, A. Hatano, T. Hata, and S. Ōmura: Structure of carzinophilin. IV. Structure elucidation by nuclear magnetic resonance spectroscopy (2). Chem. Pharm. Bull., 32, 2995-3002 (1984).
296) S. Ōmura, H. Sano, S. Yamamoto, M. Tsuzuki, and H. Tanaka: Studies on two deoxygenases involved in the synthesis of tylosin in Streptomyces fradiae. Biochim. Biophys. Acta, 802, 141-147 (1984).
297) H. Ikeda, M. Inoue, H. Tanaka, and S. Ōmura: Interspecific protoplast fusion among macrolide producing streptomycetes. J. Antibiot., 37, 1224-1230 (1984).
298) S. Ōmura, K. Miyano, A. Nakagawa, H. Sano, K. Komiyama, and I. Umezawa: Chemical modification and antitumor activity of herbimycin A 8,9-epoxide, 7,9-cyclic carbamate, and 17 or 19-amino derivatives. J. Antibiot., 37, 1264-1267 (1984).
299) S. Ōmura, M. Murata, N. Imamura, Y. Iwai, and H. Tanaka: Oxetin, a new antimetabolite from an actinomycete. Fermentation, isolation, structure and biological activity. J. Antibiot., 37, 1324-1332 (1984).
300) S. Ōmura, A. Taki, K. Matsuda, and Y. Tanaka: Ammonium ions suppress the amino acid metabolism involved in the biosynthesis of protylonolide in a mutant of Streptomyces fraidae. J. Antibiot., 37, 1362-1369 (1984).
301) Y. Tanaka, R. Masuma, and S. Ōmura: Control of ammonium ion level of efficient nanaomycin production. J. Antibiot., 37, 1370-1375 (1984).
302) S. Ōmura, Y. Tanaka, Y. Takahashi, I. Chia, M. Inoue, and Y. Iwai: Irumamycin, an antifungal 20-membered macrolide produced by a Streptomyces. Taxonomy, fermentation and biological properties. J. Antibiot., 37, 1572-1578 (1984).
303) S. Ōmura and A. Nakagawa: Macrolide antibiotics (Review article). Pharmacia, 20, 1226-1232 (1984).