Publications: 2005-2009

877) K. Shiomi, H. Ui, H. Suzuki, H. Hatano, T. Nagamitsu, D. Takano, H. Miyadera, T. Yamashita, K. Kitao, H. Miyoshi, A. Harder, H. Tomoda, and S. Ōmura: A γ-lactone form of nafuredin, nafuredin-γ, also inhibits helminth complex I. J. Antibiot., 58, 50-52 (2005).

878) K. Shiomo, R. Matsui, M. Isozaki, H. Chiba, T. Sugai Y. Yamaguchi, R. Masuma, H. Tomoda, T. Chiba, H. Yan, Y. Kitamura, W. Sugiura, S. Ōmura, and H. Tanaka: Fungal phenalenones inhibit HIV-1 integrase. J. Antibiot., 58, 65-68 (2005).

879) K. Shiomi, K. Hatae, H. Hatano, A. Matsumoto, Y. Takahashi, C.-L. Jiang, H. Tomoda, S. Kobayashi, H. Tanaka, and S. Ōmura. A new antibiotic, antimycin A9, produced by Streptomyces K01-003. J. Antibiot., 58, 74-78 (2005).

880) K. Yoshida, T. Sunazuka, K. Nagai, A. Sugawara, A. Cho, T. Nagamitsu, Y. Harigaya, K. Otoguro, K. S. Akagawa, and S. Ōmura. Macrolides with promotive activity of monocyte to macrophage differentiation. J. Antibiot., 58, 79-81 (2005).

881) T. Sunazuka, T. Shirahata, S. Tsuchiya, T. Hirose, R. Mori, Y. Harigaya, I. Kuwajima, and S. Omura. A concise stereoselective route to the indoline spiroaminal framework of neoxaline and oxaline. Org. Lett., 7, 941-943 (2005).

882) T. Sunazuka, K. Yoshida, N. Kojima, T. Shirahata, T. Hirose, M. Handa, D. Yamamoto, Y. Harigaya, I. Kuwajima, and S. Ōmura: Total synthesis of (-)-physovenine from (-)-3a-hydroxyfuroindoline. Tetrahedron Lett., 46, 1459-1461 (1005).

883) A. Takahashi, J. Inokoshi, H. Chiba, S. Ōmura, and H. Tanaka: Essential regions for antiviral activities of actinohivin, a sugar-binding anti-human immunodeficiency virus protein from an actinomycete. Arch. Biochem. Biophys., 437, 233-240 (2005).

884) T. Fukuda, A. Matsumoto, Y. Takahashi, H. Tomoda, and S. Omura: Phenatic acids A and B, new potentiators of antifungal miconazoole activity produced by Streptomyces sp. K03-0132. J. Antibiot., 58, 252-259 (2005).

885) T. Sunazuka, P. A. Sprengeler, A. B. Smith, III, and S. Omura: Absolute stereochemistries and total synthesis of (+/)(-)-macrosphelides, potent, orally bioavailable inhibitors of cell-cell adhesion. Tetrahedron, 61, 3789-3803 (2005).

886) T. Fukuda, Y. Yamaguchi, R. Masuma, H. Tomoda, and S. Ōmura: Citridones, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938. I. Taxonomy, fermentation, isolation and biological properties. J. Antibiot., 58, 309-314 (2005).

887) T. Fukuda, H. Tomoda, and S. Ōmura: Citridones, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938. II. Structure elucidation. J. Antibiot., 58, 315-321 (2005).

888) N. Koyama, T. Nagahiro, Y. Yamaguchi, T. Ohshiro, R. Masuma, H. Tomoda, and S. Ōmura: Spylidone, a novel inhibitor of lipid droplet accumulation in mouse macrophages produced by Phoma sp. FKI-1840. J. Antibiot., 58, 339-345 (2005).

889) R. Uchida, R. Imasato, Y. Yamaguchi, R. Masuma, K. Shiomi, H. Tomoda, and S. Omura: New sesquicillins, insecticidal antibiotics produced by Albophoma sp. FKI-1778. J. Antibiot., 58, 339-345 (2005).

890) T. Hirose, T. Sunazuka, D. Yamamoto, N. Kojima, T. Shirahata, Y. Harigaya, I. Kuwajima, and S. Ōmura: Determination of the absolute stereochemistry and asymmetric total synthesis of madindolines A and B: a practical improvement to a second-generation approach from the first-generation. Tetrahedron, 61, 6015-6039 (2005).

891) F. V. Rao, D. R. Houston, R. G. Boot, J. M. Aerts, M. Hodkinson, J. Adams, K. Shiomi, S. Ōmura, and D. M. F. van Aalten: Specificity and affinity of natural products cyclopentapeptide inhibitors against A. fumigatus, human and bacterial chitinases. Chem. & Biol., 12, 65-76 (2005).

892) H. Matsui, M. Eguchi, K. Ohsumi, A. Nakamura, Y. Isshiki, K. Sekiya, Y. Kikuchi, T. Nagamitsu, R. Masuma, T. Sunazuka, and S. Ōmura: Azithromycin inhibits the formation of flagellar filaments without suppressing flagelin synthesis of Salmonella enterica serovar typhimurium. Antimicrob. Agents and Chemother., 49, 3396-3403 (2005).

893) H. Ui, S. Asanuma, H. Chiba, A. Takahashi, Y. Yamaguchi, R. Masuma, S. Omura, and H. Tanaka: Mycophenolic acid inhibits syncytium formation accompanied by reduction of gp120 expression. J. Antibiot., 58, 514-518 (2005).

894) M. Shibuya, B. B. Snider, Y. Sakano, H. Tomoda, S. Ōmura, and Y. Ebizuka: Revised structures of Epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929. Antibiot., 58, 590-601 (2005).

895) T. Sunazuka, T. Hirose, and S. Ōmura: Total synthesis of madindolines, potent selective inhibitors, novel bioactive microbial metabolites. J. Synth. Org. Chem., Japan, 63, 1090-1101 (2005).

896) A. Kageyama, Y. Takahashi, T. Seki, H. Tomoda, and S. Ōmura: Oryzihumus leprocrescens gen nov., sp. nov. J. Syst. Evol. Microbiol., 55, 2555- 2559 (2005).

897) T. Nagamitsu, Y. Harigaya, and S. Ōmura: Total synthesis of borrelidin (Review article). Proc. Japan Acad., 81, 244-256 (2005).

898) N. Koyama, T. Nagahiro, Y. Yamaguchi, R. Masuma, H. Tomoda, and S. Ōmura. Stemphones, novel potentiators of imipenem activity against mechicillin-resistant Staphylococcus aureus, produced by Aspergillus sp. FKI-2136. J. Antibiot., 58, 695-703 (2005).

899) R. Uchida, R. Imasato, K. Shiomi, H. Tomoda, and S. Ōmura: Yaequinones J1 and J2, novel insecticidal antibiotics from Penicillium sp. FKI-2140. Org. Lett., 7, 5701-5704 (2005).

900) H. Gouda, T. Sunazuka, H. Ui, M. Handa, Y. Sakoh, Y. Iwai, S. Hirono, and S. Ōmura: stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics NMR spectroscopy, and the modified Mosher method. Proc. Natl. Acad. Sci. (USA), 102, 18286-18291(2005).

901) T. Sunazuka and S. Ōmura: Total synthesis of α-pyrone meroterpenoids, novel bioactive microbial metabolites. Chem. Rev., 105, 4559-4580 (2005).

902) R. Uchida, R. Imasato, Y. Yamaguchi, R. Masuma, K.Shiomi, H. Tomoda, and S. Ōmura: New insecticial antibiotics, hydroxyfungerins A and B, produced by Metahizium sp. FKI-1079. J. Antibiot., 58, 804-809 (2005).

903) Y. Yamaguchi, R. Masuma, H. Tomoda, and S. Ōmura: A new species of Dinemasporium from sugar cane on Irabujima island, Japan. Mycoscience, 46, 367-369 (2005).

904) K. Nagai, T. Doi, T. Sekiguchi, I. Namatame, T. Sunazuka, H. Tomoda, S. Omura, and T. Takahashi: Synthesis and biological evaluation of a beauveriolide analogue library. J. Combinatorial Chem., 8, 103-109 (2006).

905) J. Matsuo, T. Shirahata, and S. Omura: catalytic and stereoselective glycosylation with glycosyl N-trichloro-acetylcarbamate. Tetrahedron Lett., 47, 267-271 2006).

906) R. Uchida, Y.-P. Kim, I. Namatame, H. Tomoda, and S. Ōmura: Sespendole, a new inhibitor of lipid droplet synthesis in macrophages, produced by Pseudobotrytis terrestris FKA-25. J. Antibiot., 59, 93-97 (2006).

907) Y. Takahashi, A. Matsumoto, K. Morisaki, and S. Ōmura: Patulibacer minatonensis gen. nov., sp. nov., a novel actinobacterium isolated using an agar medium supplemented with superoxide dismutase, and proposal of Patulibacteracea fam. nov. Int. J. Syst. Evol. Microbol., 56, 401-406 (2006).

908) H. Gouda, T. Sunazuka, K. Yoshida, A. Sugawara, Y. Sakoh, S. Omura, and S. Hirono: Three-dimensional solution of monocyte-to-macrophage differentiation. Bioorg. Med. Chem. Lett., 16, 2406-2409 (2006).

909) D. Yamamoto, T. Sunazuka, T. Hirose, N. Kojima, E. Kaji, and S. Ōmura: Design, synthesis, and biological activities of madindoline analogues. Bioorg. Med. Chem. Lett., 26, 2807-2811 (2006).

910) R. Horsefield, V. Yankovskaya, G. Sexton, W. Whittingham, K. Shiomi, S. Ōmura, B. Byrne, G. Cecchini, and S. Iwata: Structural and computational analysis of the quinone-binding site of Complex II (Succinate-ubiquinone oxidoreductase). A mechanism of electron stransfer and proton conduction during ubiquinone reduction. J. Biol. Chem., 281, 7309-7316 (2006).

911) M. Iwatsuki, H. Tomoda, R. Uchida, H. Gouda, S. Hirono, and S. Ōmura: Lariatins, antimycobacterial peptides produced by Rhodococcus sp. K01-B0171, have a lasso structure. J. Am. Chem. Soc., 128, 7486-7491 (2006).

912) R. Uchida, H. Tomoda, and S. Ōmura: Biosynthesis of sespendole. J. Antibiot., 59, 298-302 (2006).

913) C. N. Tetzlaff, Z. You, D. E. Cane, S. Takamatsu, S. Ōmura, and H. Ikeda: A gene cluster for biosynthesis of sesquiterpenoid antibiotic pantalenolactone in Streptomyces avermitilis. Biochem., 45, 6179-6186 (2006).

914) R. Uchida, Y.-P. Kim, T. Nagamitsu, H. Tomoda, and S. Ōmura: Structure elucidation of fungal sespendole, and an inhibitor of lipid droplet synthesis in macrophages. J. Antibiot., 59, 338-344 (2006).

915) Z. You, S. Ōmura, H. Ikeda, and D. E. Cane: Pentalenolactone biosynthesis, molecular cloning and assignment of biochemical function to ptIH, a non-heme iron dioxygenase of Streptomyces avermitilis. J. Am. Chem. Soc., 128, 6566-6567 (2006).

916) T. Fukuda, Y. Hasegawa, K. Hagimori, Y. Yamaguchi, R. Masuma, H. Tomoda, and S. Ōmura. Tensidols, new potentiators of antifungal miconazole activity, produced by Aspergillus niger FKI-2342. J. Antibiot., 59, 480-485 (2006).

917) T. Hirose, T. Sunazuka, D. Yamamoto, E. Kaji, and S. Ōmura. Synthetoc applications of a three component mannich reaction. Total synthesis of IL-6 inhibitor (+)-madindoline A and B. Tetrahedron Lett. 48. 6761-6764 (2006).

918) A. Kageyama, Y. Takahashi, and S. Ōmura. Microbacterium deminutum sp. nov., Micobacterium pumilum sp. nov. and Microbacterium aoyamense sp. nov. Int. J. System. Evol. Microbiol., 56, 2113-2117 (2006).

919) T. Shirahata, T. Sunazuka, K. Yoshida, D. Yamamoto, Y. Harigaya, I. Kuwajima, T. Nagai, H. Kiyohara, H. Yamada, and S. Ōmura. Total synthesis, elucidation of absolute stereochemistry, and adjuvant activity of trihydroxy fatty acids. Tetrahedron, 62, 9483-9496 (2006).

920) H. Ui, K. Shiomi, H. Suzuki, H. Hatano, H. Orimoto,Y. Yamaguchi, R. Masuma, K. Sakamoto, K. Kita, H. Miyoshi, H. Tomoda, H. Tanaka, and S. Ōmura: Paecilamminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550. J. Antibiot., 59, 591-596 (2006).

921) T. Ohshiro, I. Namatame, K. Nagai, T. Sekiguchi, T. Doi, T. Takahashi, K. Akasaka, L. L. Rudel, H. Tomoda, and S. Ōmura: Absolute stereochemistry of fungal beauveriolide III and ACAT inhibitory activity of four stereoisomers. J. Org. Chem., 71, 7643-7649 (2006).

922) R.Uchida, R. Imasato, Y. Yaguchi, R. Masuma, K. Shiomi, H. Tomoda, and S, Ōmura: Yaequinolones, new insecticidal antibiotics produced by Penicillium sp. FKI-2140. I. Taxonomy, fermentation, isolation and biological activity. J. Antibiot., 59, 646-651 (2006).

923) R. Chida, R. Imasato, H. Tomoda, and S. Ōmura: Yaequinolones, new insecticidal antibiotics produced by Penicillium sp. FKI-2140. J. Antibiot., 59, 652-658 (2006).

924) T. Fukuda, Y. Sakabe, H. Tomoda, and S. Ōmura: Fungal citridone D having a novel phenylfuropyridine skeleton. Chem. Pharm. Bull., 54, 1659-1661 (2006).

925) S. Tshuchiya, T. Sunazuka, T. Hirose, R. Mori, T. Tanaka, M. Iwatsuki, and S. Ōmura: Asymmetric total synthesis of (+)-K01-0509B: Determination of absolute configuration. Org. Lett.,, 8, 5577-5580 (2006).

926) S. Monma, T. Sunazuka, K.Nagai, T. Arai, K. Shiomi, R. Matsui, and S. Ōmura: Verticilide: Elucidation of absolute configuration and total synthesis. Organic Lett., 8, 5601-5601 (2006).

927) T. Hirose, T. Sunazuka, Y. Noguchi, Y. Yamaguchi, H. Hanaki, K. B. Sharpless, and S. Ōmura: Rapid eSARf via Click Chemistry: An alkyne-bearing spiramycin is fused with diverse azides to yield new triazole-antibacterial candidates. Heterocycles, 69, 55-61 (2006).

928) C. Ichino, N. Soonthornchareonnon, W. Chuakul, H. Kiyohara, A. Ishiyama, H. Sekiguchi, M. Namatame, K. Otoguro, S. Ōmura, and H. Yamada: Screening of Thai medicinal plant extracts and their active constituents for In Vitro antimalarial activity. Phytother. Res., 20, 307-309 (2006).

929) C. Ichino, H. Kiyohara, N. Soonthornchareonnon, W. Chuakul, A. Ishiyama, H. Sekiguchi, M. Namatame, K. Otoguro, and S. Ōmura, and H. Yamada: Antimalarial activity of biflavonoids from Ochna integerrima. Planta Medica, 72, 611-614 (2006).

930) S, Ōmura: Being fascinated by macrolides for 40 years (Rev. article). Farumashia, 42, 979-983 (2006).

931) International contribution towards the development of therap;eutic agents for the control of tropical diseases (Review article).　K. Otoguro and S. Ōmura. Infectious Disease, 35, 1-18 (2005)

932) H. Ikeda and S. Ōmura: New system for the production of secondary metabolites by a versatile host genetically optimized. (Rev. article). Kagaku to Seibutsu. 44, 391-398 (2006).

933) R. Quaderer, S. Ōmura, H. Ikeda, and D. E. Cane: Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to Ptll, a cytochrome P450 of Streptomyces avermitilis. J. Am. Chem. Soc., 128, 13036-13037 (2006).

934) H. Ui, K. Shiomi, H. Suzuki, H. Hatano, H. Morimoto, Y. Yamaguchi, R. Masuma, T. Sunazuka, H. Shimamura, K. Sakamoto, K. Kita, H. Miyoshi, H. Tomoda, and S. Ōmura: Verticipyrone, a new NADH-fumarate reductase inhibitor, produced by Verticillium sp. FKI-1083. J. Antibiot., 59, 785-790 (2006).

935) T. Hirose, T. Sunazuka, D. Yamamoto, M. Mouri, Y. Hagiwara, T. Matsumaru, E. Kaji, and S. Ōmura: Studies toward the total synthesis of irumamycin: stereoselective preparation of the C(15)-C(27) segment via two-directional chain synthesis. Tetrahedron Lett., 48, 413-416 (2007).

936) A. Matsumoto, Y. Takahashi, Y. Iwai, and S. Ōmura: Isolation of Gram-positive bacteria with high G+C from inside soil aggregates. Actinomycetol., 20, 30-34 (2006).

937) S. Iwasaki and S. Ōmura: Search for protein farnesyltransferase inhibitors of microbial origin; our strategy and results as well as the results obtained by other groups (Rev. article). J. Antibiot., 60, 1-12 (2007).

938) H. Shimamura, T. Sunazuka, T. Izuhara, T. Hirose, K. Shiomi, and S. Ōmura: Total synthesis and biological evaluation of verticipyrone and analogues. Org. Lett., 9, 65-67 (2007).  

939) S. Ōmura: Discovery of Avermectin and its development (Review article). Jpn. J. Antibiot., 59, Suppl. 106-113 (2006).

940) A. Kageyama, Y. Takahashi, and S. Ômura:  Mycobacterium terricolae sp. nov., isolated from soil in Japan.  J. Gen. Appl. Microbiol., 53, 1-5 (2007).

941) H. Sudo, K. Ozaki, H. Muramatsu, K. Kamei, K. Yogo, O. Cynshin, H. Koga, Z. Itoh, S. Ōmura, and H. Takanashi: Mitemcinal (GM-611), an orally active motilin agonist, facilitates defecation in rabbits and dogs without causing loose stools.  Neurogastroenterol. Motil, 19, 318-326 (2007).

942) H. Ui, A. Ishiyama, H. Sekiguchi, M. Namatame, A. Nishihara, Y. Takahashi, K. Shiomi, K. Otoguro, and S. Ōmura: Selective and potent in vitro antimalarial activities found in four microbial metabolites.  J. Antibiot., 60, 220-222 (2007).

943) T. Nagamitsu, D. Takano, K. Marumoto, T. Fukuda, K. Furuya, K. Otoguro, K. Takeda, I. Kuwajima, Y. Harigaya, and S. Ōmura: Total synthesis of borrelidin.  J. Org. Chem., 72, 2744-2756 (2007).

944) H. Takanashi, K. Yogo, K. Ozaki, H. Koga, Z. Itoh, and S. Ōmura:  In vitro pharmacological characterization of mitemcinal (GM-611), the first acid-resistant non-peptide motilin receptor agonist, in smooth muscle of rabbit small intestine. Pharmacology, 79, 137-148 (2007).

945) K. Ozaki, H. Sudo, H. Muramatsu, K. Yogo, K. Kamei, H. Koga, Z. Itoh, S. Ōmura, and H. Takanashi:  Mitemcinal (GM-611), an orally active motilin receptor agonist, accelerates colonic motility and bowel movement in conscious dogs. Inflammopharmacology, 15, 36-42 (2007).

946) K. Kita, K. Shiomi, and S. Ōmura:  Advances in drug discovery and biochemical studies (Review article):  Trends Parasitol., 23, 223-229 (2007).

947) S. Ōmura and K. Shiomi: Discovery, chemistry, and chemical biology of microbial products (Review article).  Pure Appl. Chem., 79, 581-591 (2007).

948) S. Tsuchiya, T. Sunazuka, T. Shirahata, T. Hirose, E. Kaji, and S. Ōmura: A new method for efficient coupling of indole and epoxide catalyzed with Yb(OTf)3, and application to the total synthesis of kurasoin B. Heterocycles, 72, 91-94 (2007).

949) D. E. Cane, X. He, S. Kobayashi, S.Ōmura, H. Ikeda: Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression and mechanistic study of the germacradienol/geosmin synthase. J. Antibiotc. 59, 471-479 (2006).

950) N. Arai, N. Chikaraishi, S. Ōmura, and I Kuwajima: First total synthesis of the antitumor compound (-)-kazusamycin A and absolute structure determination. Org. Lett., 6, 2845-2848 (2004).

951) P. Parini, M. Davis, A. T. Lada, S. K. Erickson, T. L. Wright, U. Gustafsson, S. Sahlin, C. Einarsson, M. Eriksson, B. Angelin, H. Tomoda, S.Ōmura, M. C. Willingham, and L. L. Rudel: ACAT2 is localized to hepatocyte and is the major choresterol-esterifing enzyme in human liver. Circulation, 110, 2017-2023 (2004).

952) Y. J. Li, A. Azuma, J. Usuki, S. Abe, K. Matsuda, T. Sunazuka, T. Shimizu, Y. Hirata, H. Inagaki, T, Kawada, S. Takahashi, S. Kudoh, and S. Ōmura: EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-signaling in lung fibroblasts. Respir. Res., 7, 16 (2006).

953) A. H. Banskota, J. B. McAlpine, D. Sørensen, M. Aouidate, M. Piraee, A. M. Alarco, S. Ōmura, K. Shiomi, C. M. Farnet, and E. Zazopoulos: Isolation and identification of three new 5-alkenyl- 3,3(2H)-furanones from two Streptomyces species using a genomic screening approach. J. Antibiot., 59, 168-176 (2006).

954) N. Koyama, T. Ohshiro, H. Tomoda, and S. Ōmura: Fungal isobisvertinol, a new inhibitor
of lipid droplet accumulation in mouse macrophages. Org. Lett., 9, 425-428 (2007).

955) T. Ohshiro, L. L. Rudel, S. Ōmura, and H. Tomoda: Selectivity of microbial acyl-CoA: cholesterol acyltransferase inhibitors toward isozymes. J. Antibiot., 60, 43-51 (2007).

956) Z. You, S. Ōmura, H. Ikeda, and D. E. Cane: Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate. Arch. Biochem. Biophys., 459, 233-240 (2007).

957) M. Iwatsuki, R. Uchida, Y. Takakusagi, A. Matsumoto, C.-L. Jiang, Y. Takahashi, M. Arai, S. Kobayashi, M. Matsumoto, J. Inokoshi, H. Tomoda, and S. Ōmura: Lariatins, novel anti mycobacterial peptides with a Lasso structure, produced by Rhodococcus jostii K01-B0171. J. Antibiot., 60, 357-363 (2007).

958) K.-I. Ozaki, K. Yogo, H. Sudo, M. Onoma, K. Kamei, M. Akima, H. Koga, Z. Itoh, S. Ōmura, and H. Takanashi: Effects of mitemcinal (GM-611), an acid-resistant nonpeptide motilin receptor agonist, on the gastrointestinal contractile activity in conscious dogs. Pharmacology, 79, 223-235
(2007).

959) S. Ōmura: Story of avermectin: discovery practice and its biosynthesis. Antibiotics and Chemother., 23, 67-79 (2007).

960) T. Sunazuka, M. Handa, T. Hirose, T. Matsumaru, Y. Togashi, K. Nakamura, Y. Iwai, and S. Ōmura: Synthesis of the oxabridged octalin system of two anti-anaerobe antibiotics, luminamicin and lustromycin. Tetrahedron Lett., 48, 5297-5300 (2007).

961) K. Hagimori, T. Fukuda, Y. Hasegawa, S. Ōmura, and H. Tomoda: Fungal malformins inhibit bleomycin-induced G2 checkpoint in Jurkat cells. Biol. Pharm. Bull., 30, 1379-1383 (2007).

962) I. Ara, T. Kudo, A. Matsumoto, Y. Takahashi, and S. Ōmura: Nonomuraea bangladeshensis sp. nov. and Nonomuraea coxensis sp. nov. Int. J. Sys. Evol. Microbiol., 57, 1504-1509 (2007).

963) H. Tomoda and S. Lŭura: Potential therapeutics for obesity and atherosclerosis: Inhibitors of neutral lipid metabolism from microorganisms (Review article). Pharmacol. and Ther., 15, 375-389 (2007).

964) K. Motohashi, R. Ueno, M. Sue, K. Furihata, T. Matsumoto, T. Dairi, S. Lŭura, and H. Seto: Studies on terpenoids produced by actinomycetes: oxaloterpins A, B, C, D, and E, diterpenes from Streptomyces sp. KO-3988. J. Nat. Prod., 70, 1712-1717 (2007).

965) K. Kimura, M. Tabo, M. Itoh, K. Mizoguchi, A. Kato, M. Suzuki, Z. Itoh, S. Ōmura, and H. Takanashi: Preclinical electrophysiology assays of mitemcinal (GM-611), a novel prokinetic agent derived from erythromycin. J. Toxicol. Sci., 32, 217-230 (2007).

966) A. Kageyama, Y. Takahashi, Y. Matsuo, K. Adachi, H. Kasai, Y. Shizuri, and S. Ōmura: Microbacterium flavum sp. nov. and Microbacterium lacus sp. nov., isolated from marine environments. Actinomycetol. 21, 53-58 (2007).

967) Y. Hasegawa, T. Fukuda, K. Hagimori, H. Tomoda, and S. Ōmura: Tensyuic acids, new antibiotics produced by Aspergillus niger FKI-2342. Chem. Pharm. Bull., 55, 1338-1341 (2007).

968) A. Kageyama, Y. Takahashi, and S. Ōmura: Humihabitans oryzae gen. Nov., sp. nov. Int. J. Sys. Evol. Microbiol., 57, 2163-2168 (2007).

969) A. Kageyama, Y. Takahashi, Y. Matsuo, H. Kasai, Y. Shizuri, and S.Ōmura: Microbacterium sediminicola sp. nov. and Microbacterium marinilacus sp. nov., isolated from marine environments. Int. J. Sys. Evol. Microbiol., 57, 2355-2359 (2007).

970) A. Matsumoto, Y. Takahashi, M. Fukumoto, and S. Ōmura: Actinocatenispora sera sp. nov., isolated long-term culturing. Int. J. Sys. Evol. Microbiol., 57, 2651-2654 (2007).

971) I. Ara, T. Kudo, A. Matsumoto, Y. Takahashi, and S. Ōmura: Nonomuraea maheshkhaliensis sp. nov., a novel actinomycete isolated from mangrove rhizosphere mud. J. Gen. Appl. Microbiol., 53, 159-166 (2007).

972) A. Kageyama, Y. Takahashi, M. Yasumoto-Hirose, H. Kasai, Y. Shizuri, and S. Ōmura: Janibacter corallicola sp. nov., isolated from coral in Palau. J. Gen. Appl. Microbiol., 53, 185-189 (2007).

973) Z. You, S. Ōmura, H. Ikeda, D. E. Cane, and G. Jogl: Crystal structure of the non-heme iron dioxygenase PtIH in pentalenolactone biosynthesis. J. Biol. Chem., 282, 36552-36560 (2007).

974) K. Yogo, K. Ozaki, H. Takanashi, M. Koto, Z. Itoh, and S. Ōmura: Effects of motilin and mitemcinal (GM-611) on gastrointestinal contractile activity in Rhesus Monkeys in vivo and in vitro. Dig. Dis. Sci., 52, 3112-3122 (2007).

975) R. Saitoh, T. Miyayama, T. Mitsui, Y. Akiba, A. Higashida, S. Takata, T. Kawanishi, Y. Aso, Z. Itoh, and S. Ōmura: Nonlinear intestinal pharmacokinetics of mitemcinal, the first acid-resistant non-peptide motilin receptor agonist, in rats. Xenobiotica, 37, 1421-1432 (2007).

976) A. Sugawara, T. Sunazuka, T. Hirose, K. Nagai, Y. Yamaguchi, H. Hanaki, K. B. Shapless, and S. Ōmura: Design and synthesis via click chemistry of 8,9-anhydroerythromycin a 6,9-hemiketal analogues with anti-MRSA and -VRE activity. Bioorg. Med. Chem. Lett., 17, 6340-6344 (2007).

977) A. Fukumoto, Y.-P. Kim, A. Matsumoto, Y. Takahashi, K. Shiomi, H. Tomoda, S.Ōmura: Cyslabdan, a new potentiator of imipenem activity against methicillinresistant Staphylococcus aureus, produced by Stretpomyces sp. K04-0144. I. Taxonomy, fermentation, isolation and structure elucidation. J. Antibiot., 61, 1-6 (2008).

978) A. Fukumoto, Y.-P. Kim, H. Hanaki, K. Shiomi, H. Tomoda, and S. Ōmura: Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Streptomycs sp. K04-0144. II. Biological activity. J. Antibiot., 61, 7-10 (2008).

979) S. Ōmura: Ivermectin: 25 years and still going strong (Review article). Int. J. Antimicrob. Agents, 31, 91-98 (2008).

980) A. Kageyama, K. Morisaki, S. Ōmura, and Y. Takahashi: Arthrobacter oryzae sp. nov. and Arthrobacer humicola sp. nov. Int. J. Sys. Evol. Microbiol., 58, 53-56 (2008).

981) H. Ikeda, T. Sunazuka, H. Suzuki, Y. Hamasaki, S. Yamazaki, S. Ōmura, and A. Hatamochi: EM703, the new derivative of erythromycin, inhibits transcription of type I collagen in normal and scleroderma fibroblasts. J. Dermatol. Sci., 49, 195-205 (2008).

982) T. Sunazuka, H. Shudo, K. Nagai, K. Yoshida, Y. Yamaguchi, H. Hanaki, and S. Ōmura: 4”’-N-Demethylspiramycin dervatives: Synthesis and evaluation of effectiveness against drugresistant bacteria. J. Antibiot., 61, 175-184 (2008).

983) H. Gouda, Y. Yanai, A. Sugawara, T. Sunazuka, S. Ōmura, and S. Hirono: Computational analysis of the binding affinities of the natural-product cyclopentapeptides argifin and argadin to chitinase B from Serratia marcescens. Bioorg. Med. Chem. 16, 3565-3579 (2008).

984) A. Ishiyama, K. Otoguro, M. Namatame, A. Nishihara, T. Furusawa, Y. Takahashi, R. Masuma, K. Siomi, and S. Ōmura: Simaomicin: effects on the cell cycle of synchronized cultured Plasmodium falciparum. J. Antibiot., 61, 254-257 (2008).

985) P. Khaomek, C. Ichino, A. Ishiyama, H. Sekiguchi, M. Namatame, N. Rungrungsi, E. Saifah, H. Kiyohara, K. Otoguro, S. Ōmura, and H. Yamada: In vitro antimalarial activity of prenylated flavonoids from Erythrina fusca. J. Nat. Med., 62, 217-220 (2008).

986) T. Sunazuka, T. Hirose, and S. Ōmura:  Efficient total synthesis of novel bioactive microbial metabolites (Review Article). Acc. Chem. Res., 41, 302-314 (2008).

987) E. Fujii, K. Kimura, K. Mizoguchi, A. Kato, H. Takanashi, Z. Itoh, S. Ōmura, and M. Suzuki:  Assessment of the carcinogenic potential of mitemcinal (GM-611): Increased incidence of malignant lymphoma in a rat carcinogenicity study. Toxicol. Applied Pharmacol., 228, 1-7 (2008).

988) T. Mogi, H. Ui, K. Shiomi, S. Ōmura, and K. Kita: Gramicidin S identified as a potent inhibitor for cytochrome bd-type quinol oxidase.  FEBS Lett., 582, 2299-2302 (2008).

989) M. Komatsu, M. Tsuda, S. Ōmura, H. Oikawa, and H. Ikeda: Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol.  Proc. Natl. Acad., Sci., USA, 105,7422-7427 (2008).

990) Y. Kojima, T. Sunazuka, K. Nagai, K. Julfakyan, T. Fukuda, H. Tomoda, and S. Ōmura: Total synthesis of malfomin C, an inhibitor of bleomycin-induced G2 arrest.  J. Antibiot., 61, 297-302 (2008).

991) T. Hirose and S. Ōmura: Click chemistry and drug discovery (Review article). Kagaku to Kogyo,60, 984-986 (2007).

992) A. Kageyama, Y. Matuo, H. Ksaai, Y. Shizuri, S. Ōmura, and Y. Takahashi: Microbacterium awajiense sp. nov., Microbacterium fluvii sp. nov. and Microbacterium pygmaeum sp. nov. Actino- mycetologica, 22, 1-5 (2008).

993) K. Otoguro, A. Ishiyama, M. Namatame, A. Nishihara, T. furusawa, R. Masuma, K. Shiomi, Y. Takahashi, H. Yamada, and S. Ōmura: Selectiive and potent in vitro antitrypanosomal activities of
ten microbial metabolites. J. Antibiot., 61, 372-378 (2008).

994) A. Matsumoto, M. Yamada, S. Ōmura, and Y. Takahashi: Microterricola viridarii gen. nov., sp.
nov., a new member of the family Microbacteriaceae.  Int. J. Sys. Evol. Microbiol. 58,1019-1023 (2008).

995) T. Matsumaru, T. Sunazuka, T. Hirose, A. Ishiyama, M. Namatame, T. Fukuda, H. Tomoda, K. Otoguro, and S. Ōmura: Synthesis and biological properties of tensyuic acids B, C, and E, and investigation of the optical purity of natural tensyuic acid B: Tetrahedron, 64, 7369-7377 (2008).

996) T. Nagamitsu, D. Takano, M. Seki, S. Araima, M. Ohtawa, K. Shiomi, Y. Harigaya, and S. Ōmura: The total synthesis and biiological evaluatio nafuredin-g and its analogues. Tetrahedron 64, 8117-8127 (2008).

997) K. Nagai, T. Doi, T. Ohshiro, T. Sunazuka, H. Tomoda, T. Takahashi, and S. Ōmura: Synthesis and biological evaluation of a focused library of beauveriolides. Bioog. Med. Chem. Lett., 18, 4397-4400 (2008).

998) A. Kageyama, A. Matsumoto, S. Ōmura, and Y. Takahashi: Humibacillus xanthopallidus gen. nov. sp. nov. Int. J. Sys. Evol. Microbiol. 58, 1547-1551 (2008).

999) H. Yamazaki, N. Koyama, S. Ōmura, and H. Tomoda: Structure-activity relatiionships of stemphones, potentiators of limipenem activity against Methicillin-resistant Staphylococcus aureus. J. Antibiot., 61, 426-441 (2008).

1000) I. Ara, A. Matsumoto, M. A. Bakir, T. Kudo, S. Ōmura, and Y. Takahashi: Pseudosporangium ferrugineum gen. nov., sp. nov., a new member of the family Micromonosporaceae. Int. J. Sys. Evol. Microbiol. 58, 1653-1659 (2008).

1001) I. Ara, A. Matsumoto, M. A. Bakir, T. Kudo, S. Ōmura, and Y. Takahashi: Actinomadura bangladeshensis sp. nov. and Actinomadura chokoriensis sp. nov. Int. J. Sys. Evol. Microbiol. 58, 1653-1659 (2008).

1002) E. Abdel-Sattar, F. M. Harraz, S. M. A. Al-ansari, S. El-Mekkawy, C. Ichino, H. Kiyohara, A. Ishiyama, K. Otoguro, S. Ōmura, and H. Yamada: Acylated pregnane glycosides from Caraluma tuberculata and their antiparasitic acitvity.  Phytochemistry, 69, 2180-2186 (2008).

1003) I. Komuro, T. Sunazuka, K. S. Akagawa, Y. Yokota, A. Iwamoto, and S. Ōmura: Erythromycin derivatives inhibit HIV-1 replication in macrophages through modulation of MAPK activity to induce
small isoforms of C/EBPb. Proc. Natl. Acad. Sci., USA, 105, 12509-12514 (2008).

1004) T. Fukuda, K. Sugiyama, S. Arima, Y. Harigaya, T. Nagamitsu, and S. Ōmura: Total syntehsis of salinosporamide A. Org. Lett., 10, 4239-4242 (2008).

1005) A. Ishiyama, K. Otoguro, M. Namatame, A. Nishihara, T. Frusawa, R. Masuma, K. Shiomi, Y. Takahashi, M. Ichimura, H. Yamada, and S. Ōmura: In vitro and in vivo antitrypanosomal activity of two microbial metabolites, KS-505a and alazopeptin. J. Antibiot., 61, 627-632 (2008).

1006) T. Hirose, T. Sunazuka, S. Tsuchiya, T. Tanaka, Y. Kojima, R. Mori, M. Iwatsuki, and S. Ōmura: Total synthesis and determination of the absolute configuration of guadinomines B and C2,  Chem. Eur. J. 14, 8220-8238 (2008).

1007) M. Onoma, K. Yogo, K. Ozaki, K. Kamei, M. Akima, H. Koga, Z. Itoh, S. Omura, and H. Takanashi:  Oral mitemcinal (GM-611), an erythromycin-derived prokinetic, accelerates normaland experimentally delayed gastric emptying in conscious dogs. Clin. Exp. Pharmacol. Physiol., 35, 35-42 (2008).

1008) E. Fjii, K. Kimura, K. Mizoguchi, A. Kato, H. Takanashi, Z. Itoh, S. Omura, and M. Suzuki: Assessment of the carcinogenic potential of mitemcinal (GM-611): Increased incidence of malignant lymphoma in a rat carcinogenicity study. Toxicol. Appl. Pharmacol., 228, 1-7 (2008).

1009) K. Yogo, M. Onoma, K. Ozaki, M. Koto, Z. Itoh, S. Ōmura, and H. Takanashi: Effects of oral mitemcinal (GM-611), erythromycin, EM-574. Dig. Dis. Sci., 53, 912-918 (2008).

1010) K. Ozaki, M. Monnai, M. Onoma, H. Muramatsu, K. Yogo, T. Watanabe, Y. Oda, K. Katagiri, H. Arakawa, Z. Itoh, S. Ōmura, and H. Takanashi: Effects of mitemcinal (GM-611), an orally active erythromycin-derived prokinetic agent, on delayed gastric emptying and postprandial glucose in a new minipig model of diabetes. J. Diabetes and its Complication, 22, 339-347 (2008).

1011) M. Onoma, K. Ozaki, K. Yogo, M. Monnai, H. Muramatsu, K. Kamei, Y. Kawabe, S. Hayashi, T. Shiga, S. Matsuo, M. Suzuki, Z. Itoh,  S. Ōmura, and H. Takanashi: Mitemcinal (GM-611), an orally active motilin receptor agonist, improves delayed gastric emptying in a canine model of diabetic gastroparesis. Clinic. Exp. Pharmacol. Physiol., 35, 788-796 (2008).

1012) S. Hayashi, E. Fujii, A. Kato, K. Kimura, K. Mizoguchi, M. Suzuki, T. Sugimoto, H. Takanashi, Z. Itoh, S. Ōmura, and H. Wanibuchi: Characterization of multinuclear hepatocytes induced in rats by mitemcinal (GM-611), an erythromycin derivative.  Toxicol. Pharmacol., 36, 858-865 (2008).

1013) A. Kageyama, T. Haga, H. Kasai, Y. Shizuri, S. Ōmura, and  Y. Takahashil: Marihabitans asiaticum gen. nov., sp. nov., a meso-diaminopimelic acid-containing member of the family Intrasporangiaceae. Int. J. Sys. Evol. Microbiol., 58, 2429-2432 (2008).

1014)New lycorine-tyoe alkaloid from Lycoris traubii and evaluation of antitrpanosomal and antimalarial actvities of lycorine derivatives. Y. Toriizuka, E. Kinoshita, N. Kogure, M. Kitajima,
A. Ishiyama, K. Otoguro, H. Yamada, S. Ōmura, and H. Takayama
Bioorg. Med. Chem., 16, 10181-10189 (2008).

1015) I. Ara, A. Matsumoto, M. A. Bakir, T. Kudo, S. Ōmura, and
Y. Takahashi: Actinomadura maheshkihaliensis sp. nov., a novel actinomycete isolated from mangrove rhizosphere soil on Maheshkhai, Bangladesh. J. Gen. Appl. Microbiol., 54, 335-342 (2008).

1016) Y. Iwatsuki, R. Uchida, H. Yoshijima, H. Ui, K. Shiomi, A. Matsumoto, Y. Takahashi, A. Abe, H. Tomoda, and S. Ōmura: Guadinomines, type III secretion system inhibitors, produced by Streptmyces sp. K01-0509. I. Taxonomy, fermentation, isolation and biological properties. J. Antibiot., 61, 222-229 (2008).

1017) M. Iwatsuki, R. Uchida, H. Yoshijima, H. Ui, K. Shiomi, Y.-P. Kim, T. Hirose, T. Sunazuka, A. Abe, H. Tomoda, and S. Ōmura: Guadinomines, type III secretion system inhibitors, produced by Streptomyces sp. K01-0509. II. Physico-chemical properties and structure elucidation. J. Antibiot., 61, 230-236 (2008).

1018) A. Das, M. A. Davis, H. Tomoda, S. Ōmura, and L. L. Rudel: Identification of the interaction site within Acyl-CoA:Cholesterol Acyl-transferase 2 for the isoform-specific inhibitor pyripyropene A. J. Biol. Chem., 283, 10453-10460 (2008).

1019) T. Nagamitsu, D. Takano, M. Seki, S. Arima, M. Ohtawa, K. Shiomi, Y. Harigaya, and S. Ōmura:The total synthesis and biological evaluation of nafuredin-g and its analogues.  Tetrahedron, 64, 8117-8127 (2008).

1020) D. Matsuda, I. Namatame, T. Ohshiro, S. Ishibashi, S. Ōmura, and H. Tomoda: Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor. J. Antibiot., 61, 318-321 (2008).

1021) T. Ohshiro, S. Ohte, D. Matsuda, M. Ohtawa, T. Nagamitsu, T. Sunazuka, Y. Harigaya, L. L. Rudel, S. Ōmura, and H. Tomoda:
Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA:Cholesterol acyltransferase 2 isozyme. J. Antibiot., 61, 503-508 (2008).

1022) T. Fukuda, Y. Hasegawa, Y. Sakabe, H. Tomoda, and S. Ōmura: Citrinamides, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938. J. Antibiot., 61, 550-555 (2008).

1023) P. Parini, U. Gustafsson, M. A. Davis, L. Larsson, C. Einarsson, M. Wilson, M. Rudling, H. Tomoda, S. Ōmura, S. Sahlin, B. Angelin, L. L. Rudel, M. Eriksson: Cholesterol synthesis inhibition elicits an integrated molecular response in human livers including decreased ACAT2. Arterioscler. Thromb. Basc. Biol. 28, 1200-1206 (2008).

1024) H. Shimamura, H. Gouda, K. Nagai, T. Hirose, M. Ichioka,
Y. Furuya, Y. Kobayashi, S. Hirono, T. Sunazuka, and S. Ōmura:
Structure determination and total synthesis of bottromycin A2:  a potent antibiotic against MRSA and VRE. Angew. Chem. Int. Ed., 48, 914-917 (2009).

1025) T. Mogi, H. Ui, K. Shiomi, S. Ōmura, H. Miyoshi, and Kiyoshi Kita:
Antibiotics LL-Z1272 identified as novel inhibitors discriminating bacterial and mitochondrial quinol oxidases. Biochim. Biophys. Acta, 1787, 129-133 (2009).

1026) T. Mogi, K. Matsushita, Y. Murase, K. Kawahara, H. Miyoshi, H. Ui,
K. Shiomi, S. Ōmura, and K. Kita: Identification of new inhibitors for alternative NADH dehydrogenase (NDH-II). FEMS Microbiol. Lett., 291, 157-161 (2009).

1027) H. Nakano and S. Ōmura: Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine. J. Antibiot., 62, 17-26 (2009).

1028) Y. Yamada, Y. Takahashi, T. Kubota, J. Fromont, A. Ishiyama, K. Otoguro, H. Yamada, S. Ōmura, and J. Kobayashi: Zamamidine C, 3,4-dihydro-6-hydroxy-10,11-epoxymanzamine A, and 3,4-dihydro-
manzamine J N-oxide, new manzamine alkaloids from sponge Amphimedon sp. Tetrahedron, 65, 2313-2317 (2009).

1029) T. Teramoto, T. Matsunaga, M. Toba, T. Sunazuka, S. Ōmura, and S. Ohmori: Role of dexamethasone and oncosatin M on the formation of vacuoles in human fetal liver cells. Biol. Pharm. Bull., 32, 209-212 (2009).

1030) J. Inokoshi, K. Kawamoto, Y. Takagi, M. Matsuhama, S. Ōmura, and
H. Tomda: Expression of two human acyl-CoA: diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes. J. Antibiot., 62, 51-54 (2009).

1031) T. Hirose, T. Sunazuka, A. Sugawara, A. Endo, K. Iguchi, T. Yamamoto, H. Ui, K. Shiomi, T. Watanabe, K. Barry Sharpless, and S. Ōmura: Chitinase inhibitors: extraction of the active framework from natural argifin and use of in situ click chemistry. J. Antibiot., 62, 277-282 (2009).

1032) M. Ohtawa, S. Ogihara, K. Sugiyama, K. Shiomi, Y. Harigaya, T. Nagamitsu, and S. Ōmura: Enantioselective total synthesis of atpenin A5. J. Antibiot., 62, 289-294 (2009).

1033) A. Ishiyama, K. Otoguro, M. Iwatsuki, M. Namatame, A. Nishihara, K. Nonaka, Y. Kinoshita, Y. Takahashi, R. Masuma, K. Shiomi, H. Yamada. and S. Ōmura: In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A amd B, alamethicin I and tsushimycin. J. Antibiot., 62, 303-308 (2009).

1034) T. Sunazuka, A. Sugawara, K. Iguchi, T. Hirose, K. Nagai, Y. Noguchi, Y. Saito, T. Yamamoto, H. Ui, H. Gouda, K. Shiomi, T. Watanabe, S. Ōmura: Argifin; efficient sold phase total synthesis and evaluation of analogues of acyclic peptide. Bioorg. & Med. Chem., 17, 2751-2758 (2009).

1035) A. Matsumoto, H. Kasai, Y. Matsuo, S. Ōmura, Y. Shizuri, and Y. Takahashi: Ilumatobacter fluminis gen. nov., sp. nov., a novel aftinobacterium isolated from the sediment of an estuary. J. Gen. Appl. Microbiol., 55, 201-205 (2009).

1036) T. Mogi, Y. Ano, T. Nakatsuka, H. Toyama, A. Muroi, H. Miyoshi, C. T. Migita, H. Ui, K. Shiomi, S. Ōmura, K. Kita, and K. Matsushita:
Biochemical and spectroscopic properties of cyanide-insensitive quinol oxidase from Gluconobacter oxydans. J. Biochem., 146, 263-271 (2009).

1037) E. Abdel-Sattar, N. G. Shehab, C. Ichino, H. Kiyohara, A. Ishiyama, K. Otoguro, S. Ōmura, and H. Yamada: Antitrypanosomal activity of some pregnane glycosides isolated from Caralluma species. Phytomedicine, 16, 659-664 (2009).

1038) K. Shiomi and S. Ōmura: A new target for antiparasite antibiotics, NADH-fumarate reductase system  (Rev. article). Jpn. J. Vet. Parasitol., 8, 3-10 (2009).

1039) T. Mogi, T. Kawakami, H. Arai, Y. Igarashi, K. Matushita, M. Mori, K. Shiomi, S. Ōmura, S. Harada, and K. Kita: Siccanin resiscovered as a species-selective succinate dehydrogenase inhibitor. Biochem., 146, 383-387 (2009).

1040) J. Inokoshi, Y. Takagi, R. Uchida, R. Masuma, S. Ōmura, and H. Tomoda: Production of a new type of amidepsine with a sugar moiety by static fermentation of Humicola sp. FO-2942. J. Antibiot., 62, 1-8 (2009).

1041) T. Nagamitsu, K. Marumoto, A. Nagayasu, T. Fukuda, S. Arima, R. Uchida, T. Ohshiro, Y. Harigaya, H. Tomoda, and S. Ōmura: Total synthesis of amidepsine B and revision of its absolute configuration, J. Antibiot., 62, 69-74 (2009).

1042) T. Mogi, Y. Murase, M. Mori, K. Shiomi, S. Ōmura, M. P. Paranagama, and K. Kita: Polymyxin B identified as an inhibitor of alternative NADH dehydrogenase and malate: Quinone oxidoreductase from the Gram-positive bacterium Mycobacterium smegmatis. J. Biochem., 146, 491-499 (2009).

1043) H. Yamazaki, K. Kobayashi, D. Matsuda, K. Nonaka, R. Masuma, S. Ōmura, and H. Tomoda: Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1: I. Taxonomy, fermentation, isolaion and biological properties. J. Antibiot., 62, 195-200 (2009).

1044) H. Yamazaki, S. Ōmura, and H. Tomoda: Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages produced by Penicillium cecidicola FKI-3765-1: II. Structure elucidation. J. Antibiot., 62, 207-211 (2009).

1045) H. Yamazaki, K. Nonaka, R. Masuma, S. Ōmura, and H. Tomoda: Xanthoradones, new potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2: I. Taxonomy, fermentation, isolation and biological properties. J. Antibiot., 62, 431-434 (2009).
        
1046) H. Yamazaki, S. Ōmura, and H. Tomoda: Xanthoradones, new potentiators of imipenem activity against methicillin-resistant  Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2  II. Structure elucidation. J. Antibiot., 62, 435-437 (2009).

1047) H. Matsui, H. Hanaki, K. Takahashi, A. Yokoyama, T. Nakae, K. Sunagawa, and S. Ōmura: Rapid detection of vaginal Candida species by newly developed immunochromatography. Clin. Vacc. Immunol., 16, 1366-1368 (2009).

1048) T. Hirose, T. Sunazuka, A. Sugawara, Y. Noguchi, T. Tanaka, K. Iguchi, T. Yamamoto, H. Gouda, K. Shiomi, and S. Ōmura: Solid-phase total synthesis of the chitinase inhibitor argadin using a supported acetal resin. J. Antibiot., 62, 495-500 (2009).

1049) Y. Kojima, T. Sunazuka, K. Nagai, T. Hirose, M. Namatame,
A. Ishiyama, K. Otoguro, and S. Ōmura: Solid-phase synthesis and biological activity of malformin C and its derivatives. J. Antibiot., 62, 681-686 (2009).

1050) T.Teramoto, T. Matsunaga, M. Tobe, T. Sunazyjam S. Ōmura, and S. Ohmori: Role of dexamethasone and oncostatin M on the formation of vacuoles in human fetal liver cells. Biol. Pharm. Bull., 32, 209-212 (2009).

1051) T. Ohshiro, D. Matsuda, K. Nagai, T. Doi, T. Sunazuka, T. Tahahashi, L. L. Rudel, S. Ōmura, and H. Tomoda: The selectivity of beauveriolide derivatives  in inhibition toward the two isozymes of Acyl-CoA: cholesterol acyltransferase. Chem. Pharm. Bull., 57, 377-381 (2009).

1052) H. Gouda, T. Sunazuka, K. Iguchi, A. Sugawara, T. Hirose, Y. Noguchi, Y. Saito, Y. Yanai, T. Yamamoto, T. Watanabe, K. Shiomi, S. Ōmura, and S. Hirono: Computer-aided rational molecular design of argifin-derivatives with increased inhibitory activity against chitinase B from Serratia marcescens. Bioorg. Med. Chem. Lett., 19, 2630-2633 (2009).

1053) S. Takishima, A. Ishiyama, M. Iwatsuki, K. Otoguro, H. Yamada, S. Ōmura, H. Kobayashi, R. W. M. van Soest, and S. Matsunaga: Merobatzelladines A and B, Anti-infective tricyclic guanidines from a marine sponge Monanchora sp. Org. Lett., 11 2655-2658 (2009).

1054) M. Iwatsuki Y. Koizumi, H. Gouda, S. Hirono, H. Tomoda, and S. Ōmura: Lys17 in the ‘lasso’ peptide lariatin A is responsible for anti-mycobacerial activity. Bioorg. Med. Chem. Lett., 19, 2888-2890 (2009).

1055) H. Gouda, S. Terashima, K. Iguchi, A. Sugawara, Y. Saito, T. Yamamoto, T. Hirose, K. Shiomi, T. Sunazuka, S, Ōmura, and S. Hirono: Molecular modeling of human acidic mammalian chitinase in complex with the natural-product cyclopentapeptide chitinase inhibitor argifin. Bioorg. Med. Chem., 17. 6270-6278 (2009).

1056) H. Tanaka, H. Chiba, J. Inokoshi, A. Kuno, T. Sugai, A. Takahashi, Y. Ito, M. Tdunoda, K. Suzuki, A. Takenaka, T. Sekiguchi, H. Umeyama, J. Hirabayashi,and S. Ōmura: Mechanism by which the lectin actinohivin blocks HIV infection of target cells. Proc. Natl. Acad. Sci., USA, 106, 15633-15638 (2009).