Publications: 2015-current

1175) K. Nonaka, T. Kaneta, S. Ōmura, and R. Masuma: Transcriptional analysis of genes encoding proteins significantly increased in Kitasatospora setae KM-6054T under submerged culture. Mycoscience, 56, 29-33 (2015).

1176) Y. Yamada, T. Kuzuyama, M. Komatsu, K. Shin-ya, S. Ōmura, D. E. Cane, and H. Ikeda: Transcriptional analysis of genes encoding proteins significantly increased in Kitasatospora setae KM-6054T under submerged culture. Proc. Natl. Acad. Sci., USA, 112, 857-862 (2015).

1177) T. Nakashima, Y. Kamiya, M. Iwatsuki, N. Sato, Y. Takahashi, and S. Ōmura: Mangromicin C, a new analog of mangromicin. J. Antibiot., 68, 220-222 (2015).

1178) A. Take, A. Matsumoto, S. Õmura, and Y. Takahashi: Streptomyces lactacystinicus sp. nov. and Streptomyces cyslabdanicus sp. nov., producing lactacystin and cyslabdan, respectively. J. Antibiot., 68, 322-327 (2015).

1179) T. Nakashima, Y. Kamiya, K. Yamaji, M. Iwatsuki, N. Sato, Y. Takahashi, and S. Õmura: New steroidal compounds from an actionete strain, Lechevalieria aerocolonigenes K10-0216. J. Antibiot., 68, 348-350 (2015).

1180) A. Ishiyama, M. Iwatsuki, R. Hokari, M. Sawa, S. Ōmura, and K. Otoguro: Antimalarial activity of kinase inhibitor, nilotinib, in vitro and in vivo. J. Antibiot., 68, 469-472 (2015).

1181) K. Nonaka, T. Chiba, T. Suga, Y. Asami, M. Iwatsuki, R. Masuma,S. Ōmura, and K. Shiomi: Coculnol, a new penicillic acid produced by a coculture of Fusarium solani FKI-6853 and Talaromyces sp. FKA-65. J. Antibiot., 68, 530-532 (2015).

1182) K. Nonaka, M. Iwatsuki, S. Horiuchi, K. Shiomi, S. Ōmura, and R. Masuma: Induced production of BE-31405 by co-culturing of Talaromyces siamensis FKA-61 with a variety of fungal strains. J. Antibiot., 68, 573-578 (2015).

1183) T. Ishii, K. Nonaka, A. Sugawara, M. Iwatsuki, R. Masuma, T. Hirose, T. Sunazuka, S. Ōmura, and K. Shiomi: Cinetrins D and E, and virgaricin B, three novel compounds produced by a fungus, Virgaria boninensis FKI-4958. J. Antibiot., 68, 633-637 (2015).

1184) T. Suga, Y. Asami, S. Hashimoto, K. Nonaka, M. Iwatsuki, T. Nakashima, R. Sugahara, T. Shiotuki, T. Yamamoto, Y. Shionohara,Ichimaru, M. Murai, H. Miyoshi, S. Ōmura, and K. Shiomi: Ascosteroside C, a new mitochondrial respiration inhibitor discovered by pesticidal screening using recombinant Saccharomyces cerevisiae. J. Antibiot., 68, 649-652 (2015).

1185) T. Seki, A. Matsumoto, S. Ōmura, and Y. Takahashi: Distribution and isolation of strains belonging to the order Solirubrobacterales. J. Antibiot., 68, 763-766 (2015).

1186) M. Ohtawa, M. Matsunaga, K. Fukunaga, R. Shimizu, E. Shimizu, S. Arima, J. Ohmori, K. Kita, K. Shiomi, S. Ōmura, and T. Nagamitsu:Design, synthesis, and biological evalutation of air-stable nafuredin-g analogs as complex I inhibitors. Bioorg. & Med. Chem., 23, 932-943 (2015).

1187) N. Iwanaga, S. Nakamura, K. Oshima, T. Kajihara, T. Takazono, T.Miyazaki, K. Izumikawa, K. Yanagihara, A. Sugawara, T. Sunazuka. S. Ōmura, and S. Kohno: Macrolides promote CCL2-mediated macrophage recruitment and clearance of nasopharyngeal pneumococcal colonization in mice. J. Infect. Dis., 212, 1150-1159 (2015).

1188)       S. Kaifuchi, M. Mori, K. Nonaka, R. Masuma, S. Ōmura and K. Shiomi: AUkulactone C, a new NADH-fumarate reductase inhibitor produced by Talaromyces sp. FKI-6713. J. Gen. Appl. Microbiol., 61, 57-62 (2015).

1189)       T. Suga, Y. Asami, S. Hashimoto, K. Nonaka, M. Iwatsuki, T. Yamamoto, T. Shinohara, N. Ichimaru, M. Murai, H. Miyoshi, S. Ōmura, and K. Shiomi: Trichopolyn VI: a new peptaibol insecticidal compound discovered using a recombinant Saccharomyces cerevisiae screening system. J. Gen. Appl. Microbiol, 61, 82-87 (2015).

1190) T. Yamada, T. Ideguchi-Matsushita, T. Hirose, T. Shirahata, R. Hokari, A. Ishiyama, M. Iwatsuki, A. Sugawara, YT. Kobayashi, K. Otogurao, S. Ōmura, and T. Sunazuka: A symmetric total synthesis of indole alkaloids containing an indoline spiroaminal framework. Chem. Eur. J., 21, 11855-11864 (2015).

1191) Identification of natural inhibitors of Entamoeba histolytica cysteinesynthase from microbial secondary metabolites. M. Mori, G. Jealaru, Y. Masuda, K. Sakai, K. Tsukui, D. Waluyo, Tarwadi, Y. Watanabe, K. Nonaka, A. Matsumpoto, S. Omura, T. Nozaki, and K. Shiomi: Frontiers in Microbiol., 6, 962 (2015)

1192) N. L. Kalonji, K. Nomura, T. Kawase, C. Oita, H. Kubo, T. Sato, T. Yanagisawa, T. Sunazuka, S. Ōmura, amnd M. Yamaya: The non-antibiotic macrolide EM-900 inhibits rhinovirus infection and cytokine production in human airway epithelial cells. Physiol. Rep., pil: e12557 (2015).

1193) A. Sugawara, M. Kubo, T. Nakashima, T. Hirose, N. Tsunoda, K. Yahagi, Y. Asami, T. Yamada, K. Shiomi, Y. Takahashi, S. Ōmura, and T. Sunazuka: Jietacins with potent nematocidal activity: efficient isolation of novel analogs and divergent total synthesis of jietacin A, B, C, and D.
Tetrahedron, 71, 2140-2152 (2015).

1194) T. Nakashima, P. Boonsnongcheep. T. Kimura, M. Iwatsuki, N. Sato, K. Nonaka, S. Prathanturarug, Y. Takahashi, and S. Ōmura: New compounds nanaomycin F and G, discovered by physicochemical screening from a culture broth of Streptomuyces rosa subsp. notoensis OS-3966. J. Biosci. Bioeng., 120, 596-600 (2015).

1195) M. Ohtawa, Y. Hishinuma, E. Takagi, T. Yamada, F. Ito, R. Uchida, Y. P. Kim, S. Ōmura, H. Tomoda, and T. Nagamitsu: Synthesis and structural revision of cyslabdan.Chem. Pharm. Bull., 64, 1370-1377 (2016).

1196) S. Mukai, S. Molriya, M. Hiramoto, H. Kazawa, H. Kokuba, X.-F. Che, T. Yokoyama, S. Sakamoto, A. Sugawara, T. Sunazuka, S. Ōmura, H. Handa, T. Itoi, ande K. Miyazawa: Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell line. Int. J. Oncol., 48, 45-54 (2016).

1197) S. Toguchi, T. Hirose, K. Yorita, K. Fukui, K. B. Sharpless, S.Ōmura, and T. Sunazuka: In Situ Click chemistry for the identification of a potent D-amino acid oxidase inhibitor. Chem. Pharm. Bull., 64, 695-703 (2016).

1198) T. Yamada, K. Suzuki, T. Hirose, T. Furuta, Y. Ueda, T. Kawabata, S. Ōmura, and T. Sunazuka: Organocatalytic site-selective acylation of avermectin B2a, a unique endectocidal drug. Chem. Pharm. Bull., 64, 856-864 (2016).

1199) M. Ganaha, K. Yoshii, Y. Otsuki, M. Iguchi, Y. Okamoto, K. Iseki, S. Ban, A. Ishiyama. R. Hokari, M. Iwatsuki, K. Otoguro, S. Ōmura, T. Hashimoto, M. Noji, and A. Umeyama: In vitro antitrypanosomal activity of the secondary metabolites from the mutant strain IU-3 of the insect pathogenic fungus Ophiocordyceps conccidiicola NBRC 100683. Chem. Pharm. Bull., 64, 988-990 (2016).

1200) Y. Noguchi, T. Hirose, A. Ishiyama, M. Iwatsuki, K. Otoguro, T. Sunazuka, and S. Ōmura: Synthesis ands stereochemical determination of an antiparasitic pseudo-aminal type monoterpene indole alkaloid. J. Nat. Med., 70, 302-317 (2016).

1201) S. Ōmura: A splendid gift from the earth: the origins and impact of the avermectins. (Nobel Lecture). Angewandte Chemie, 55, 10190-10209 (2016).

1202) A. Take, T. Nakashima, Y. Inahashi, K. Shiomi, Y. Takahashi, S. Ōmura, and A. Matsumoto: Analyses of the cell-wall peptidoglycan structures in three genera Micromonospora, Catenuloplanes, and Couchioplanes belonging to the family Micromonosporaceae by derivatization with FDLA and PMP using LC/MS. J. Gen. Appl. Microbiol., 62, 199-205 (2016).

1203) A. Sugawara, H. Shima, A. Sueki, T. Hirose, H. Matsui, H. Nakano, H. Hanaki, K. A. Akagawa, S. Ōmura, and T. Sunazuka: Non-antibiotic 12-membered macrolides: design, synthesis and biological evaluation in a cigarette-smoking model. J. Antibiot., 69, 319-326 (2016).

1204) T. Suga, M. Shiina, Y. Asami, M. Iwatsuki, T. Yamamoto, K. Nonaka,R. Masuma, H. Matsui, H. Hanaki, S. Iwamoto, H. Onodera, K. Shiomi, and S. Ōmura: Paraphaeosphaeride D and berkleasmin F, new circumventors of arbekacin resistance in MRSA, produced by Paraphaeosphyaeria sp. TR-022. J. Antibiot., 69, 605-610 (2016).

1205) H. Ogawas, A. Iwasaki, S. Sumimoto, Y. Kanamori, O. Ohno, M. Iwatsuki, A. Ishiyama, R. Hokari, K. Otoguro, S. Ōmura, and K. Suenaga: Janadolide, a cyclic polyketide peptide hybrid possessing a tert-butyl group from an Okeania sp. marine cyanobacterium. J. Nat. Prod., 79, 1862-1866 (2016).

1206) R. Mingma, K. Tanaka, S. Ōmura, Y. Takahashi, and A. Matsumoto Actinohabdospora filicis gen. nov., sp. nov., a new member of the family Micromonosporaceae. Int. J. System. Evol. Microbiol., 66, 3071-3077 (2016)

1207) T. Yamamoto, H. Matsui, K. Yamaji, T. Takahashi, A. Overby, M. Nakamura, A. Matsumoto, K. Nonaka, T. Sunazuka, S. Ōmura, and H. Nakano: Narrow-sectrum inhibitors targeting an alternative menaquinone biosynthetic pathway of Helicobacter pylori. I. Infet. Chemother., 22, 587-592 (2016).

1208) I. Tojima, S. Shimizu, T. Ogawa, H. Kouzaki, S. Ōmura, T. Sunazuka, and T. Shimizu: Anti-inflammatory effects of a novel non-antibiotic macrolide, EM900, on mucus secretion of airway epithelium. Aurix Nasus Larynx, 42, 332-336 (2016).

1209) T. Nakashima, R. Miyano, M. Iwatsuki, T. Shirahata, T. Kimura, Y. Asami, Y. Kobayashi, K. Shiomi, G. A. Petersson, Y. Takahashi, and S. Ōmura: Iminimycin A, the new iminium metabolite produced by Streptomyces griseus OS-3601. J. Antibiot., 69, 611-615 (2016).

1210) T. Kimura, M. Iwatsuki, Y. Asami, A. Ishiyama, R. Hokari, K. Otoguro, A. Matsumoto, N. Sato, K. Shiomi, Y. Takahashi, S. Ōmura, and T. Nakashima: Anti-trypanosomal compound, sagamilactam, a new polyene macrocyclic lactam from Actinomadura sp. K13-0306. J. Antibiot., 69, 818-824 (2016).

1211) R. Mingma, K. Duangmal, A. Take, Y. Inahashi, S. Ōmura, Y. Takahashi, and A. Matsumoto: Proposal of Sphaerimonospora cavernae gen. nov., sp. nov. and transfer of Microbispora mesophila (Zhang et al., 1998) to Sphaerimonospora maesophila comb. Nov. and Microbispora thailandensis (Duangmal et al., 2012) to Sphaerimonospora thailandensis comb. nov. Int. J. System Evol. Microbiol., 66, 1735-1744 (2016).

1212) Y. Inahashi, T. Shiraishi, K. Palm, Y. Takahashi, S. Ōmura, T. Kuzuyama, and T. Nakashima: Biosynthesis of trehangelin in Polymorphospora rubra K078-0510: identification of metabolic pathway to Angelyl-CoA. ChemBioChem., 17, 1442-1447 (2016).

1213) T. Nakashima, R. Miyano, H. Matsuo, M. Iwatsuki, T. Shirahata, Y. Kobayashi, K. Shiomi, G. A. Petersson, Y. Takahashi, and S. Ōmura: Absolute configuration of iminimycin B, a new indolizidine alkaloid, from Streptomyces griseus OS-3601.Tetrahedron Lett., 57, 3284-3286 (2016).

1214) Y. Tong, M. Liu, Y. Zhang, X. Liu, R. Huang, F. Song, H. Dai, B. Ren, N. Sum, G. Pei, J. Bian, X-M. Jia, G. Huang, X. Zhou, S. Li, B. Zhang, T. Fukuda, H. Tomoda, S. Ōmura, R. D. Cannon, R. Calderone, and L. Zhang: Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters. Syn. System. Biotechnol., 1, 158-168 (2016).

1215) R. Horikoshi, K. Goto, M. Mitomi, K. Oyama, T. Sunazuka, and S. Ōmura: Identification of pyripyropene A as a promising insecticidal compound in a microbial metabolite screening. J. Antibiot., 70, 272-276 (2017).