Publications: 2015-current

1175) K. Nonaka, T. Kaneta, S. Ōmura, and R. Masuma: Mariannaea macrochlamydospora, a new hyphomycete (Nectriaceae) from soil in the Bonin Islands, Japan. Mycoscience, 56, 29-33 (2015).

1176) Y. Yamada, T. Kuzuyama, M. Komatsu, K. Shin-ya, S. Ōmura, D. E. Cane, and H. Ikeda: Terpene synthases are widely distributed in bacteria. Proc. Natl. Acad. Sci., USA, 112, 857-862 (2015).

1177) T. Nakashima, Y. Kamiya, M. Iwatsuki, N. Sato, Y. Takahashi, and S. Ōmura: Mangromicin C, a new analog of mangromicin. J. Antibiot., 68, 220-222 (2015).

1178) A. Take, A. Matsumoto, S. Ōmura, and Y. Takahashi: Streptomyces lactacystinicus sp. nov. and Streptomyces cyslabdanicus sp. nov., producing lactacystin and cyslabdan, respectively. J. Antibiot., 68, 322-327 (2015).

1179) T. Nakashima, Y. Kamiya, K. Yamaji, M. Iwatsuki, N. Sato, Y. Takahashi, and S. Ōmura: New steroidal compounds from an actinomycete strain, Lechevalieria aerocolonigenes K10-0216. J. Antibiot., 68, 348-350 (2015).
             
1180) A. Ishiyama, M. Iwatsuki, R. Hokari, M. Sawa, S. Ōmura, and K. Otoguro: Antimalarial activity of kinase inhibitor, nilotinib, in vitro and in vivo. J. Antibiot., 68, 469-472 (2015).

1181) K. Nonaka, T. Chiba, T. Suga, Y. Asami, M. Iwatsuki, R. Masuma, S. Ōmura, and K. Shiomi: Coculnol, a new penicillic acid produced by a coculture of Fusarium solani FKI-6853 and Talaromyces sp. FKA-65. J. Antibiot., 68, 530-532 (2015).

1182) K. Nonaka, M. Iwatsuki, S. Horiuchi, K. Shiomi, S. Ōmura, and R. Masuma: Induced production of BE-31405 by co-culturing of Talaromyces siamensis FKA-61 with a variety of fungal strains. J. Antibiot., 68, 573-578 (2015).

1183) T. Ishii, K. Nonaka, A. Sugawara, M. Iwatsuki, R. Masuma, T. Hirose, T. Sunazuka, S. Ōmura, and K. Shiomi: Cinatrins D and E, and virgaricin B, three novel compounds produced by a fungus, Virgaria boninensis FKI-4958. J. Antibiot., 68, 633-637 (2015).

1184) T. Suga, Y. Asami, S. Hashimoto, K. Nonaka, M. Iwatsuki, T. Nakashima, R. Sugahara, T. Shiotuki, T. Yamamoto, Y. Shinohara, Ichimaru, M. Murai, H. Miyoshi, S. Ōmura, and K. Shiomi: Ascosteroside C, a new mitochondrial respiration inhibitor discovered by pesticidal screening using recombinant Saccharomyces cerevisiae. J. Antibiot., 68, 649-652 (2015).

1185) T. Seki, A. Matsumoto, S. Ōmura, and Y. Takahashi: Distribution and isolation of strains belonging to the order Solirubrobacterales. J. Antibiot., 68, 763-766 (2015).

1186) N. Iwanaga, S. Nakamura, K. Oshima, T. Kajihara, T. Takazono, T. Miyazaki, K. Izumikawa, K. Yanagihara, A. Sugawara, T. Sunazuka. S. Ōmura, and S. Kohno: Macrolides promote CCL2-mediated macrophage recruitment and clearance of nasopharyngeal pneumococcal colonization in mice. J. Infect. Dis., 212, 1150-1159 (2015).

1187) M. Ohtawa, M. Matsunaga, K. Fukunaga, R. Shimizu, E. Shimizu, S. Arima, J. Ohmori, K. Kita, K. Shiomi, S. Ōmura, and T. Nagamitsu: Design, synthesis, and biological evalutation of air-stable nafuredin-g analogs as complex I inhibitors. Bioorg. Med. Chem., 23, 932-943 (2015).

1188) S. Kaifuchi, M. Mori, K. Nonaka, R. Masuma, S. Ōmura and K. Shiomi: Ukulactone C, a new NADH-fumarate reductase inhibitor produced by Talaromyces sp. FKI-6713. J. Gen. Appl. Microbiol., 61, 57-62 (2015).

1189) T. Suga, Y. Asami, S. Hashimoto, K. Nonaka, M. Iwatsuki, T. Nakashima, Y. Watanabe. R. Sugahara. T. Shiotsuki, T. Yamamoto, Y. Shinohara, N. Ichimaru, M. Murai, H. Miyoshi, S. Ōmura, and K. Shiomi: Trichopolyn VI: a new peptaibol insecticidal compound discovered using a recombinant Saccharomyces cerevisiae screening system. J. Gen. Appl. Microbiol, 61, 82-87 (2015).

1190) T. Yamada, T. Ideguchi-Matsushita, T. Hirose, T. Shirahata, R. Hokari, A. Ishiyama, M. Iwatsuki, A. Sugawara, Y. Kobayashi, K. Otoguro, S. Ōmura, and T. Sunazuka: Asymmetric total synthesis of indole alkaloids containing an indoline spiroaminal framework. Chem. Eur. J., 21, 11855-11864 (2015).

1191) M. Mori, G. Jeelani, Y. Masuda, K. Sakai, K. Tsukui, D. Waluyo, Tarwadi, Y. Watanabe, K. Nonaka, A. Matsumoto, S. Ōmura, T. Nozaki, and K. Shiomi: Identification of natural inhibitors of Entamoeba histolytica cysteine synthase from microbial secondary metabolites. Frontiers Microbiol., 6, 962 (2015)

1192) N. L. Kalonji, K. Nomura, T. Kawase, C. Ota, H. Kubo, T. Sato, T. Yanagisawa, T. Sunazuka, S. Ōmura, and M. Yamaya: The non-antibiotic macrolide EM-900 inhibits rhinovirus infection and cytokine production in human airway epithelial cells. Physiol. Rep., e12557 (2015).

1193) A. Sugawara, M. Kubo, T. Nakashima, T. Hirose, N. Tsunoda, K. Yahagi, Y. Asami, T. Yamada, K. Shiomi, Y. Takahashi, S. Ōmura, and T. Sunazuka: Jietacins with potent nematocidal activity: efficient isolation of novel analogs and divergent total synthesis of jietacin A, B, C, and D. Tetrahedron, 71, 2149-2157 (2015).

1194) T. Nakashima, P. Boonsnongcheep. T. Kimura, M. Iwatsuki, N. Sato, K. Nonaka, S. Prathanturarug, Y. Takahashi, and S. Ōmura: New compounds nanaomycin F and G, discovered by physicochemical screening from a culture broth of Streptomyces rosa subsp. notoensis OS-3966. J. Biosci. Bioeng., 120, 596-600 (2015).

1195) H. Nakano, A. Sugawara, T. Hirose, H. Gouda, S. Hirono, S. Ōmura, and T. Sunazuka: An architectonic macrolide library based on a C2-symmetric macrolide toward pharmaceutical compositions. Tetrahedron, 21, 6569-6579 (2015).

1196) I. Tojima, S. Shimizu, T. Ogawa, H. Kouzaki, S. Ōmura, T. Sunazuka, T. Shimizu: Anti-inflammatory effects of a novel non-antibiotic macrolide, EM-900, on mucus secretion of airway epithelium. Auris Nasus Laarynx, 42, 332-336 (2015).

1197) S. Mukai, S. Moriya, M. Hiramoto, H. Kazama, H. Kobuba, X.-F. Che, T. Yokoyama, S. Sakamoto, A. Sugawara, T. Sunazuka, S. Ōmura, H. Handa, T. Itoi, and K. Miyazawa: Macrolides sensitize EGFR-TK1-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines. Int. J. Oncology, 48, 45-54 (2016).

1198) S. Toguchi, T. Hirose, K. Yorita, K. Fukui, K. B. Sharpless, S. Ōmura, and T. Sunazuka: In Situ click chemistry for the identification of a potent D-Amino acid oxidase inhibitor. Chem. Pharm. Bull., 64, 695-703 (2016).

1199) T. Yamada, K. Suzuki, T. Hirose, T. Furuta, Y. Ueda, T. Kawabata, S. Ōmura, and T. Sunazuka: Organocatalytic site-selective acylation of avermectin B2a, a unique endectocidal drug. Chem. Pharm. Bull., 64, 856-864 (2016).

1200) M. Ganaha, K. Yoshii, Y. Otuki, M. Iguchi, Y. Okamoto, K. Iseki, S. Ban, A. Ishiyama, R. Hokari, M. Iwatsuki, K. Otoguro, S. Ōmura, T. Hashimoto, M. Noji, and A. Umeyama: In vitro antitrypanosomal activity of the secondary metabolites from the mutant strain IU-3 of the insect pathogenic fungus Ophiocordyceps coccidiicola NBRC 100683. Chem. Pharm. Bull., 64, 988-990 (2016).

1201) Y. Noguchi, T. Hirose, A. Ishiyama, M. Iwatsuki, K. Otoguro, T. Sunazuka, and S. Ōmura: Synthesis and stereochemical determination of an antiparasitic pseudo-aminal type monoterpene indole alkaloid. J. Nat. Med., 70, 302-317 (2016).

1202) S. Ōmura: A splendid gifts fron the earth: the origins and impact of the avermectins. (Nobel Lecture). Angew. Chem. Int. Ed., 55, 10190-10209 (2016).

1203) A. Take, T. Nakashima, Y. Inahashi, K. Shiomi, Y. Takahashi, S. Ōmura, and A. Matsumoto: Analyses of the cell-wall peptidoglycan structures in three genera Micromonospora, Catenuloplanes, and Couchioplanes belonging to the family Micromonosporaceae by derivatization with FDLA and PMP using LC/MS. J. Gen. Appl. Microbiol., 62, 199-205 (2016).

1204) A. Sugawara, H. Shima, A. Sueki, T. Hirose, H. Matsui, H. Nakano, H. Hanaki, K. A. Akagawa, S. Ōmura, and T. Sunazuka: Non-antibiotic 12-membered macrolides: design, synthesis and biological evaluation in a cigarette-smoking model. J. Antibiot., 69, 319-326 (2016).

1205) T. Suga, M. Shiina, Y. Asami, M. Iwatsuki, T. Yamamoto, K. Nonaka,
R. Masuma, H. Matsui, H. Hanaki, S. Iwamoto, H. Onodera, K. Shiomi, and S. Ōmura: Paraphaeosphaeride D and berkleasmin F, new circumventors of arbekacin resistance in MRSA, produced by Paraphaeosphyaeria sp. TR-022. J. Antibiot., 69, 605-610 (2016).

1206) H. Ogawa, A. Iwasaki, S. Sumimoto, Y. Kanamori, O. Ohno, M. Iwatsuki, A. Ishiyama, R. Hokari, K. Otoguro, S. Ōmura, and K. Suenaga:Janadolide, a cyclic polyketide-peptide hybrid possessing a tert-butyl group from an Okeania sp. marine cyanobacterium. J. Nat. Prod., 79, 1862-1866 (2016).

1207) R. Mingma, K. Tanaka, S. Ōmura, Y. Takahashi, and A. Matsumoto: Actinorhabdospora filicis gen. nov., sp. nov., a new member of the family Micromonosporaceae. Int. J. System. Evol. Microbiol., 66, 3071-3077 (2016)

1208) T. Yamamoto, H. Matsui, K. Yamaji, T. Takahashi, A. Overby, M. Nakamura, A. Matsumoto, K. Nonaka, T. Sunazuka, S. Ōmura, and H. Nakano: Narrow-sectrum inhibitors targeting an alternative menaquinone biosynthetic pathway of Helicobacter pylori. I. Infet. Chemother., 22, 587-592 (2016).

1209) M. Ohtawa, Y. Hishinuma, E. Takagi, T. Yamada, F. Ito, S. Arima, R. Uchida, Y.-P. Kim, S. Ōmura, H. Tomoda, and T. Nagamitsu: Synthesis and structural revision of cyslabdan. Chem. Pharm. Bull., 64, 1370-1377 (2016).

1210)    T. Nakashima, R. Miyano, M. Iwatsuki, T. Shirahata, T. Kimura, Y. Asami, Y. Kobayashi, K. Shiomi, G. A. Petersson, Y. Takahashi, and S. Ōmura: Iminimycin A, the new iminium metabolite produced by Streptomyces griseus OS-3601. J. Antibiot., 69, 611-615 (2016).

1211) T. Kimura, M. Iwatsuki, Y. Asami, A. Ishiyama, R. Hokari, K. Otoguro, A. Matsumoto, N. Sato, K. Shiomi, Y. Takahashi, S. Ōmura, and T. Nakashima: Anti-trypanosomal compound, sagamilactam, a new polyene macrocyclic lactam from Actinomadura sp. K13-0306. J. Antibiot., 69, 818-824 (2016).

1212) R. Mingma, K. Duangmal, A. Take, Y. Inahashi, S. Ōmura, Y. Takahashi, and A. Matsumoto: Proposal of Sphaerimonospora cavernae gen. nov., sp. nov. and transfer of Microbispora mesophila (Zhang et al., 1998) to Sphaerimonospora mesophila comb. nov. and Microbispora thailandensis (Duangmal et al., 2012) to Sphaerimonospora thailandensis comb. nov. Int. J. System Evol. Microbiol., 66, 1735-1744 (2016).

1213) Y. Inahashi, T. Shiraishi, K. Palm, Y. Takahashi, S. Ōmura, T. Kuzuyama, and T. Nakashima: Biosynthesis of trehangelin in Polymorphospora rubra K078-0510: identification of metabolic pathway to Angelyl-CoA. ChemBioChem., 17, 1442-1447 (2016).

1214) T. Nakashima, R. Miyano, H. Matsuo, M. Iwatsuki, T. Shirahata, Y. Kobayashi, K. Shiomi, G. A. Petersson, Y. Takahashi, and S. Ōmura: Absolute configuration of iminimycin B, a new indolizidine alkaloid, from Streptomyces griseus OS-3601.Tetrahedron Lett., 57, 3284-3286 (2016).

1215) Y. Tong, M. Liu, Y. Zhang, X. Liu, R. Huang, F. Song, H. Dai, B. Ren, N. Sum, G. Pei, J. Bian, X-M. Jia, G. Huang, X. Zhou, S. Li, B. Zhang, T. Fukuda, H. Tomoda, S. Ōmura, R. D. Cannon, R. Calderone, and L. Zhang: Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters. Syn. System. Biotechnol., 1, 158-168 (2016).

1216) R. Horikoshi, K. Goto, M. Mitomi, K. Oyama, T. Sunazuka, and S. Ōmura: Identification of pyripyropene A as a promising insecticidal compound in a microbial metabolite screening. J. Antibiot., 70, 272-276 (2017).

1217) T. Nakashima, Y. Takahashi, and S. Ōmura: Search for new compounds from Kitasato microbial library by physicochemical screening. Biochem. Pharmacol., 134, 42-55 (2017).

1218) T. Nakashima, T. Kimura, R. Miyano, H. Matsuo, T. Hirose, A. Kimishima, K. Nonaka, M. Iwatsuki, J. Nakanishi, Y. Takahash, and S. Ōmura: Nanaomycin H: a new nanaomycin analog. J. Biosci. Bioengin., 113, 765-770 (2017)

1219) A. Fukumoto, Y.P. Kim, A. Matsumoto, Y. Takahashi, M. Suzuki, H. Onodera, H. Tomoda, H. Matsui, H. Hanaki, M. Iwatsuki, S. Ōmura, and K. Shiomi: Naphthacemycins, novel circumventors of b-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities. J. Antibiot., 70, 562-567 (2017)

1220) A. Fukumoto, Y.P. Kim, M. Iwatsuki, T. Hirose, T. Sunazuka, H. Hanaki, S. Ōmura, and K. Shiomi: Naphtacemycins, novel circumventors of b-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. II. Structure elucidation. J. Antibiot., 70, 568-573 (2017).

1221) T. Hirose, Y. Kojima, H. Matsui, H. Hanaki, M. Iwatsuki, K. Shiomi, S. Ōmura, and T. Sunazuka: Total synthesis of (±)-naphthacemycin A9, possessing both antibacterial activity against methicillin-resistant Staphylococcus aureus and circumventing effect of b-lactam resistance. J. Antibiot., 70, 574-581 (2017).

1222) M. Ohtawa, S. Arima, R. Shimizu, N. Hanatani, E. Shimizu, K. Shiomi, K. Kita, S. Ōmura, and T. Nagamitsu: Development of a new air-stable structure-simlified nafuredin-g analog as a potent and selective nematode complex I inhibitor. J. Antibiot., 70, 647-654 (2017).

1223) N. Katz, N. Araujo, P. M. Z.Coelho, C. M. Morel, A. R. Linde-Arias, T. Yamada, Y. Horimatsu, K. Suzuki, T. Sunazuka, and S. Ōmura: Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis. J. Antibiot., 70, 680-684 (2017).

1224) T. Shirahata, C. Ino, F. Mizuno, Y. Asada. M. Hirotani, G. A. Petersson, S. Ōmura, T. Yoshikawa, Y. Kobayashi: g-Ionylidene-type sesquiterpenoides possessing antimicrobial activity against Porphyromonas gingivalis from Phellinus linteus and their absolute structure determination. J. Antibiiot., 70, 695-698 (2017).

1225) A. Sugawara, H. Maruyama, S. Shibusawa, H. Matsui, T. Hirose, A. Tsutsui, R. Froyman, C. Ludwig, J. Koebberling, H. Hanaki, G. Kleefeld, S. Ōmura, and T. Sunazuka: 5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity. J. Antibiot., 70, 878-887 (2017).

1226) K. Takahashi, K. Sakai, Y. Nagano, S. O. Sakaguchi, A. O. Lima, V. H. Pellizari, M. Iwatsuki, K. Takishita, K. Nonaka, K. Fujikura, S. Ōmura: Cladimarine a new anti-saprolegniasis compound isolated from the deep-sea fungus. Penicilliium coralligerum YK-247. J. Antibiot., 70, 911-914 (2017).

1227) W. Koomsiri, Y. Inahashi, T. Kimura, K. Shiomi, Y. Takahashi, S. Ōmura, A. Thamchaipenet, T. Nakashima: Bisoxazolomycin A: a new natural product from ‘Streptomyces subflavus subsp. irumaensis’ AM-3603. J. Antibiiot., 70, 1142-1145 (2017).

1228) G. Sennari, R. Saito, T. Hirose, M. Iwatsuki, A. Ishiyama, R. Hokari, K. Otoguro, S. Ōmura, and T. Sunazuka: Antimalarial troponoids, puberulic acid and viticolins: divergent synthesis and structure-activity relationship studies. Sci. Rep., 7, 7259 (2017).
 
1229) S. Ōmura and A. Crump: Ivermectin and malaria control. Malar. J. 16, 172 (2017).

1230) T. Chiba, Y. Asami, T. Suga, Y. Watanabe, T. Nagai, F. Momose, K. Nonaka, M. Iwatsuki, H. Yamada, S. Ōmura, and K. Shiomi: Herquline A, produced by Penicillium herquei FKI-7215, exhibits anti-influenza virus properties. Biosci. Biotechnol., Biochem., 81, 59-62 (2017).

1231) B. Tuvshintulga, M. AbouLalia, T. Sivakumar, D. S. Tayebwa, S. Gantuya, K. Naranbaatar, A. Ishiyama, M. Iwatsuki, K. Otoguro, S. Ōmura, M. A. Terkawi, A. Guswanto, M. A. Rizk, N. Yokoyama, I. Igarashi: Chemotherapeutic efficacies of a clofazimine and diminazene aceturate combination against piroplasm parasites and their AT-rich DNA binding activity on Basesia bovis. Sci. Rep., 7, 13888 (2017).

1232) W. Wattanasuepsin, B. Intra, A. Take, Y. Inahashi, J. Euanorasetr, S. Ōmura, A. Matsumoto, W. Panbangred,: Saccharomonospora colocasiae sp. nov., an actinomycete isolated from the rhizosphere of Colocasia esculenta. Int. J. Syst. Evol. Microbiol., 67, 4572-4577 (2017).

1233) Y. Watanabe, Y. Asami, S. Narusawa, S. Hashimoto, M. Iwatsuki, K. Nonaka, Y. Shinohara, T. Shiotsuki, N. Ichimaru, H. Miyoshi, S. Ōmura, and K. Shiomi: Ascosteroside D, a new mitochondrial respiration inhibitor disovered by pesticidal screening using insect ADP/ATP carrier protein-expressing Saccharomyces cerevisiae. J. Antibiot., 72, 146-148 (2018).

1234) H. Ando, A. Kimishima, Ml Ohara, T. Hiirose, T. Matsumaru, H. Takada, K. Morodome, T. Miyamoto, A. Sugawara, S. Ōmura, and T. Sunazuka: Toward the total synthesis of luminamicin: an anaerobic antibiotic: construction of highly functionalized cis-decalin containing a bridged ether moiety. J. Antibiot., 71, 268-272 (2018).

1235) E. Sato, M. Morita, H. Ogawa, M. Iwatsuki, R. Hokari, A. Ishiyama, S. Ōmura, A. Iwasaki, K. Suenaga: Design, synthesis and anti-malarial activities of synthetic analogs of biselyngbyolide B, a Ca2+ -pump inhibitor from marine cyanobacteria. Bioorg. Med. Chem. Lett., 28, 298-301 (2018)

1236) S. Izuta, S. Kosaka, M. Kawai, R. Miyano, H. Matsuo, A. Matsumoto, K. Nonaka, Y. Takahashi, S. Ōmura, and T. Nakashima: Dipyrimicin A and B. microbial compounds isolated from Amycolatopsis sp. K16-194. J. Antibiot., 71, 535-537 (2018).

1237) T. Kimura, Y. Inahashi, H. Matsuo, T. Suga, M. Iwatsuki, K. Shiomi, Y. Takahashi, S. Ōmura, and T. Nakashima: Pyrizomicin A and B: structure and bioactivity of new thiazolyl pyridines from Lechevalieria aerocolonigenes K10-0216. J. Antibiot., 71, 606-608 (2018).

1238) T. Suga, T. Kimura, Y. Inahashi, M. Iwatsuki, K. Nonaka, A. Take, A. Matsumoto, Y. Takahashi, S. Ōmura, and T. Nakashima: Hamuramicins A and B. 22-memembered macrolides produced by an entophytic actinomycete Allostreptomyces sp. K12-0794. J. Antibiot., 71, 619-625 (2018).

1239) W. Fukasawa, N. Mori, M. Iwatsuki, R. Hokari, A. Ishiyama, M. Nakajima, T. Ouchi, K. Nonaka, H. Kojima, H. Matsuo, S. Ōmura, and K. Shiomi: Tolyprolinol, a new dipeptide from Tolyprolinol, a new dipeptide from Tolypocladium sp. FKI-7981. J. Antibiot., 71, 682-684 (2018).

1240) S. Ōmura, Y. Asami, and A. Crump: Staurosporine: new lease of life for parent compound of today’s novel and highly successful anti-cancer drugs. J. Antibiot., 71, 688-701 (2018).

1241) K. Takahashi, K. Sakai, W. Fukasawa, Y. Nagano, SO. Sakaguchi, AO Lima, VH Pellizari, M. Iwatsuki, K. Takishita, T. Yoshida, K. Nonaka, K. Fujikura, and S. Ōmura: Quellenin a new anti-Saprolegnia compound isolated from the deep-sea fungus, Aspergillus sp. YK-76. J. Antibiot. 71, 741-744 (2018).

1242) Y. Inahashi, T. Shiraishi, A. Take, A. Matsumoto, Y. Takahashi, S. Ōmura, T. Kuzuyama, T. Nakashima: Identification and heterologous expression of the actinoallolide biosynthetic gene cluster. J. Antibiot., 71, 749-752 (2018).

1243) K. Goto, R. Horikoshi, M. Mitomi, K. Oyama, T. Hirose, T. Sunazuka, and S. Ōmura: Synnthesis and insecticidal efficacy of pyripyropene derivatives focusing on the C-1, C-7 and C-11positions’ substituent groups. J. Antibiot., 71, 785-797 (2018).

1244) K. Sakai, Y. Asami, T. Chiba, T. Suga, K. Nonaka, M. Iwatsuki, S. Ōmura, and K. Shiomi: Oxoberkedienoic acid: a new octadienoic acid derivative isolated from Talaromyces verruculosus using a chemical screening system. J. Gen. Appl. Microbiol., 64, 136-138 (2018).

1245) A. Take, Y. Inahashi, S. Ōmura, Y. Takahashi, and A. Matsumoto: Streptomyces boninensis sp. nov., isolated from soil from a limestone cave in the Ogasawara Islands. Int. J. System. Evol. Microbiol., 68, 1795-1799 (2018).

1246) M. Ohtawa, S. Arima, N.Ichida, T. Terayama, H. Ohno, T. Yamazaki, T. Ohshiro, N. Sato, S. Ōmura, H. Tomoda, and T. Nagamitsu: Desing and synthesis of A-ring simplified pyripyropene A analogues as potent and selective synthetic SOAT2 inhibitors. ChemMedChem., 13, 411-421 (2018).

1247) A. Sugawara, M. Kubo, T. Hirose, K. Yahagi, N. Tsunoda, Y. Noguchi, T. Nakashima, Y. Takahashi, C. Welz, D. Mueller, C. Mertens, J. Koebberling, S. Ōmura, and T. Sunazuka: Jietacins, azoxty antibiotics with potent nematocidal activity; design, synthesis, and biological evaluation against parasitic nematodes. Eur. J. Med. Chem., 145, 524-538 (2018).

1248) T. Kimura, A. Tajima, Y. Inahashi, M. Iwatsuki, H. Kasai, T. Mokudai, Y. Niwano, K. Shiomi, Y. Takahashi, S. Ōmura, and T. Nakashima: Mumiamicin: structure and bioactivity of a new furan fatty acid from Mumia sp. YSP-2-79. J. Gen. Appl. Microbiol., 64, 62-67 (2018).

1249) H. Matsuo, K. Nonaka, Y. Nagano, A. Yabuki, K. Fujikura, Y. Takahashi, S. Ōmura, and T. Nakashima: New metabolites, sarcopodinols A and B, isolated from deep-sea derived fungal strain Sarcopodium sp. FKJ-0025. Biosci. Biotechnol. Biochem., 82, 1323-1326 (2018).

1250) J. H. Kim, M. Komatsu, K. Shin-Ya, S. Ōmura, and H. Ikeda: Distribution and functional analysis of the phosphopantetheinyl transferase superfamily in Actinomycetales microorganisms.
Prof. Natl. Acad. Sci., USA, 115, 6828-6823 (2018).

1251) R. Miyano, H. Matsuo, K. Nonaka, T. Mokudai, Y. Niwano, K. Shiomi, Y. Takahashi, S. Ōmura, and T. Nakashima: Pochoniolides A and B, new antioxidants from the fungal strain Pochonia chlamydosporia var. spinulospora FKI-7537, J. Biosci. Bioeng., 126, 661-666 (2018).

1252) K. Sakai, T. Suga, M. Iwatsuki, T. Chinen, K. Nonaka, T. Usui, Y. Asami, S. Ōmura, and K. Shiomi: Pestiocandin, a new papulacandin class antibiotic isolated from Pestalotiopsis humus. J. Antibiot., 71, 1031-1035 (2018).

1253) N. Wakayama, S. Matsune, E. Takahara, K. Sekine, Y. Yoshida, M. Ishida, S. Yamaguchi, K.Okubo, T. Sunazuka, and S. Ōmura: Anti-inflammatory effects of EM-900 on cultured human nasal epithelial cells. J. Nippon Med. Sch., 85, 265-270 (2018).

1254) S. I. Kurimoto, T. Ohno, R. Hokari, A. Ishiyama, M. Iwatsuki, S. Ōmura, J. Kobayashi, T. Kubota: Ceratinadins E and F, new boromotyrosine alkaloids from an Okinawan marine sponge Pseudoceratina sp., Mar. Drugs, 23, E463 (2018).

1255) H. Matsuo, Y. Noguchi, A. Take, J. Nakanishi, K. Shigemura, T. Sunazuka, Y. Takahashi, S. Ōmura, and T. Nakashima: Nanaomycin I and J: new nanaomycins generated by mycothiol- mediated compounds from “Streptmyces rosa subsp. notoeneis” OS-3966. J. Biosci. Bioeng., pil: S1389-1723 (2018).

1256) R. Horikoshi, K. Goto, M. Mitomi, K. Oyama, T. Sunazuka, and S. Ōmura: Insecticidal properties of pyripyropene A, a microbial secondary metaboilite against agricultural pests. J. Pestic. Sci., 43, 266-271 (2018).

1257) M. Mori, S. Tsuge, W. Fukasawa, G. Jeelani, K. Nakada-Tsukui, K. Nonaka, A. Matsumoto, S. Ōmura, T. Nozaki, and K. Shiomi: Discovery of antiamebic compounds that inhibit systeine synthase from the enteric parasitic protest by screening of microbial secondary metabolites, Front. Cell Infect. Microbiol., 8, 409 (2018).

1258) T. Kimura, T. Suga, M. Kameoka, M. Ueno, Y. Inahashi, H. Matsuo, M. Iwatsuki, K. Shigemura, K. Shiomi, Y. Takahashi, S. Ōmura, and T. Nakashima: New tetrahydroquinoline and indoline compounds containing a hydroxyl cyclopentenone, virantmycin B and C, produced by Streptomyces sp. AM-2504. J. Antibiot., 72, 169-173 (2019)

1259) S. Ōmura and A. Crump: Lactacystin: first-in-class proteasome inhibitor still excelling and an exemplar for future antibiotic research. J. Antibiiot., 72, 189-201 (2019).

1260) Y. Sakai, M. Sato, Y. Funami, A. Ishiyama, R. Hokari, M. Iwatsuki, T. Nagai, K. Otoguro, H. Yamada, S. Ōmura, and H. Kiyohara: Peyer’s patch-immunomodulating glucans from sugar cane enhance protective immunity through stiumulation of the hemopoietic system. Int. J. Biol., Macromol., 124, 505-514 (2019).

1261) J. Nakanishi, K. Sugiyama, H. Matsuo, Y. Takahashi, S. Ōmura, and T. Nakashima: An application of photoactivatable substrate for the evaluation of epithelial-mesenchymal transition inhibitors. Anal. Sci., 35, 65-69 (2019).