Publications: 2010-2014

1057) N. Koyama, S. Kojima, T. Fukuda, T. Nagamitsu, T. Yasuhara, S. Ōmura, and H. Tomoda: Structure and total synthesis of fungal calpinactam, a new antimycobacterial agent. Org. Lett., 12, 432-435 (2010).

1058) J. Inokoshi, Y. Takagi, R. Uchida, R. Masuma, S. Ōmura, and H. Tomoda: Production of a new type of amidepsine with a sugar moiety by static fermentation of Humicola sp. FO-2942. J. Antibiot., 63, 9-16 (2010).

1059) K. Shiomi, R. Matsui, A. Kakei, Y. Yamaguchi, R. Masuma, H. Hatano, N. Arai, M. Isozaki, H. Tanaka, S. Kobayashi, A. Turberg, and S. Ōmura: Verticilide, a new ryanodine-binding inhibitor, produced by Verticillium sp. FKI-1033. J. Antibiot., 63, 77-82 (2010).

1060) R. Uchida, M. Iwatsuki, Y.-P. Kim, S. Ohte, S. Ōmura, and H. Tomoda: Nokosomycins, new antibiotics discovered in an in vivo-mimic infection model using silkworm larvae. I: Fermentation, isolation and biological properties. J. Antibiot., 63, 151-155 (2010).

1061) R. Uchida, M. Iwatsuki, Y.-P. Kim, S. Ōmura, and H. Tomoda: Nokosomycins, new antibiotics discovered in an in vivo mimic infection model using silkworm larve. II: Structure elucidation. J. Antibiot., 63, 157-163 (2010).

1062) Koyama, S. Kojima, K. Nonaka, R. Masuma, M. Matsumoto, S. Ōmura and H. Tomoda: Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905. J. Antibiot., 63, 183-186 (2010).

1063) T. Shirahata, J.-I. Matsuo, S. Teruya, N. Hirata, T. Kurimoto, N. Akimoto,T. Sunazuka, E. Kaji, and S. Ōmura: Improved catalytic and stereoselective glycosylation with glycosyl N-trichloro-acetyl- carbamate: application to various 1-hydroxy sugars. Carbohydrate Res., 345 740-749 (2010).

1064) M. Komatsu, T. Uchiyama, S. Ōmura, D. E. Cane, and H. Ikeda: Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism. Proc. Natl. Acad. Sci., USA, 107, 2646-2651 (2010).

1065) E. Takashima, H. Yamada, A. Yajima, K. Shiomi, S. Ōmura, K. Kiyoshi: A quinol peroxidase inhibitor prevents secretion of a leukotoxin from Aggregatibacter actinomycetemcomitans. I. Periodont. Res., 45, 123-128 (2010).

1066) T. Hirose, T. Sunazuka, and S. Ōmura: Recent development of two chitinase inhibitors, argifin and argadin, produced by soil microorganisms (Rev. article). Proc. Jpn. Acad., Ser. B86, 85-102 (2010).

1067) K. Otoguro, M. Iwatsuki, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, S. Sato, M.
Hatsu, H. Iinuma, S. Shibahara, S. Nimura Nimura, S. Kondo, H. Yamada, and S. Ōmura: In vitro and in vivo antiprotozoal activities of bispolides and their derivatives. J. Antibiot., 63, 275-277 (2010).

1068) H. Yamazaki, S. Ōmura, and H. Tomoda: Xanthoradone C, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2. J. Antibiot., 63, 329-330 (2010).

1069) M. Iwatsuki, Y. Kinoshita, M. Niitsuma, H. Hashida, M. Mori, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, K. Nonaka, R. Masuma, K. Otoguro, H. Yamada, K. Shiomi, and S. Ōmura: Antitrypanosomal peptaibiotics, trichosporins B-VIIa and B-VIIb, produced by Trichoderma polysporum FKI-4452. J. Antibiot., 63, 331-333 (2010).

1070) K. Otoguro, M. Iwatsuki, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, S. Shibahara, S. Kondo, H. Yamada, and S. Ōmura: Promising lead compounds for novel antiprotozoals. J. Antibiot., 63, 381-384 (2010).

1071) J. Hashida, M. Niitsuma, M. Iwatsuki, M. Mori, A. Ishiyama, M. BNamatame, A. Nishihara-Tsukashima, K. Nonaka, H. Ui, R. Masuma, K. Otoguro, H. Yamada, K. Shiomi, and S. Ōmura: Pyrenocine I, a new pyrenocine analog produced by Paecilomyces sp. FKI-3573. J. Antibiot., 63, 559-561 (2010).

1072) K. Otoguro, A. Ishiyama, M. Iwatsuki, M. Namatame, A. Nishihara-Tsukashima, T. Nakajima, S. Shibahara, S. Kondo, H. Yamada, and S. Ōmura: In vitro and in vivo anti-Trypanosoma brucei activities of phenazinomycin and related compounds. J. Antibiot., 63, 579-581 (2010).

1073) M. Iwatsuki, K. Otoguro, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, J. Hashida, T. Nakashima, R. Masuma, Y. Takahashi, H. Yamada, and S. Ōmura: In vitro antitrypanosomal activity of 12 low-molecular-weight antibiotics and observations of structure/activity relationships. J. Antibiot., 63, 619-622 (2010).

1074) A. Takahashi, J. Inokoshi, M. Tsunoda, K. Suzuki, A. Takenaka, T. Sekiguchi, S. Ōmura, and H. Tanaka: Actinohivin: specific amino acid residues essential for anti-HIV activity. J. Antibiot., 63, 661-665 (2010).

1075) M. Niitsuma, J. Hashida, M. Iwatsuki, M. Mori, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, A. Matsumoto, Y. Takahashi, H. Yamada, K. Otoguro, K. Shiomi, and S. Ōmura: Sinefungin VA and dehydrosinefungin V, new antitrypanosomal antibiotics produced by Streptomyces sp. K05-0178. J. Antibiot., 63, 673-679 (2010).

1076) T. Nakajima, T. Seki, A. Matsumoto, H. Miura, E. Sato, Y. Niwano, M. Kohno, S. Ōmura, and
Y. Takahashi: Generation of reactive oxygen species from conventional laboratory media. J. Biosci. Bioeng., 110, 304-307 (2010).

1077) Y. Kobayashi, M. Ichioka, T. Hirose, K. Nagai, A. Matsumoto, H. Matsui, H. Hanaki, R. Masuma, Y. Takahashi, S. Ōmura, and T. Sunazuka: Bottromycin derivatives: Efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities. Bioorg. Med. Chem. Lett., 20, 6116-6120 (2010).

1078) H. Yamazaki, S. Ōmura, and H. Tomoda: 6’-Hydroxy-3’-methoxy-mitorubrin, a new potentiator of antifungal miconazole ativity produced by Penicilliim radicum FKI-3765-2. Chem. Pharm. Bull., 58, 829-832 (2010).

1079) H. Gouda, T. Sunazuka, T. Hirose, K. Iguchi, N. Yamaotsu, A. Sugawara, Y. Noguchi, Y. Saito, T. Yamamoto, T. Watanabe, K. Shiomi, S. Ōmura, and S. Hirono: NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclo-pentapeptide chitinase inhibitor argifin. Bioorg. Med. Chem., 18, 5835-5844 (2010).

1080) T. Nagai, Y. Shimizu, T. Shirahata, T. Sunazuka, H. Kiyohara, S. Ōmura, and H. Yamada: Oral adjuvant activity for nasal influenza vaccines caused by combination of two trihydroxy fatty acid stereoisomers from the tuber of Pinellia ternata. Int. Immunopharmacol., 10, 655-661 (2010).

1081) N. Matoba, A. S. Husk, B. W. Barnett, M. M. Pickel, C. J. Arntzan, D. C.Montefiori, A. Takahashi, K. Tanno, S. Ōmura, H. Cao, J. P. Mooney, C. V. Hanson, and H. Tanaka: HIV-1 neutralization profile and plant-based recombinant expression of actinohivin, an Env glycan-specific lectin devoid of T-cell mitogenic ativity. PLOS One, 5, e11143-1-e11143-13 (2010).

1082) H. Yamazaki, N. Koyama, S. Ōmura, and H. Tomoda: New rugulosins, anti-MRSA antibiotics, produed by Penicilliuim radicum FKI-3765-2. Org. Lett., 12, 1572-1575 (2010).

1083) A. Matsumoto, K . Nakai, K. Morisaki, S. Ōmura, and Y. Takahashi: Demequina salsinemoris sp. nov., isolated on agar media supplemented with ascorbic acid or rutin. Int. J. Sys. Evol. Microbiol., 60, 1206-1209 (2010).

1084) Y. Inahashi, A. Matsumoto, H. Danbara, S. Ōmura, and Y. Takahashi:Phytohabitans suffuscus gen. nov., sp. nov., an actinomycete of the family Micromonosporaceae isolated from plant roots.Int. J. Sys. Evol. Microbiol., 60, 2652-2658 (2010).

1085) H. Namikoshi, T. Sunazuka, Y. Kitamura, T. Suzuki, Y Hamasaki, S. Yamazaki, S. Ōmura, and A. Hatamochi: Effect of erythromycin A and its new derivative EM201 on type I collagen production by cultured dermal fibroblasts. Arch. Dermatol. Res., 302, 341-348 (2010).

1086) S. Ikeda, H. Hanaki, C. Yanagisawa, Y. Ikeda-Dantsuji, H. Matsui, M. Iwatsuki, K. Shiomi, T. Nakae, K. Sunagawa, and S. Ōmura: Identification of the active component that induces vancomycin resistance in MRSA. J. Antibiot., 63, 533-538 (2010).

1087) M. Iwatsuki, S. Takada, M. Mori, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, K. Nonaka, R. Masuma, K. Otoguro, K. Shiomi, and S. Ōmura: In vitro and in vivo antimalarial activity of puberulic aci and its new analogs, viticolins A-C, produced by Penicillium sp. FKI-4410. J. Antibiot., 64, 183-188 (2011).

1088) K. Otsu, H. Ishinaga, S. Suzuki, A. Sugawara, T. Sunazuka, S. Ōmura、H. Jono, and K. Takeuchi: Effects of a novel nonantibiotic macrolide, EM900, on cytokine and mucin gene expression in a human airway epithelial cell line. Pharmacology, 88, 327-332 (2011).

1089) A. Crump and S. Ōmura: Ivermectin, ‘Wonder drug’ from Japan: the human use perspective (Rev. article). Proc. Jpn. Acads., Ser. B, 87, 13-28 (2011).

1090) K. Kimura, M. Iwatsuki, T. Nagai, A. Matsumoto, Y. Takahashi, K. Shiomi, S. Ōmura, and A. Abe: A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection with Citrobacer rodentium. J. Antibiot., 64, 197-203 (2011).

1091) Y. Inahashi, A. Matsumoto, S. Ōmura, Y. Takahashi: Streptosporangium oxazolinicum sp. nov., a novel endophytic actinomycete producing new antitrypanosomal antibiotics, spoxazomicins. J. Antibiot., 64, 297-302 (2011).

1092)Y. Inahashi, M. Iwatsuki, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, A. Matsumoto, T. Hirose, T. Sunazuka, H. Yamada, K. Otoguro, Y. Takashi, S. Ōmura, and K. Shiomi: Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460T. J. Antibiot., 64, 303-307 (2011).

1093) A. Ishiyama, M. Iwatsuki, M. Namatame, A. Nishihara-Tsukashima, T. Sunazuka, Y. Takahashi, S. Ōmura, and K. Otoguro: Borrelidin, a potent antimalarial: stage-specific inhibition profile of synchronized cultures of Plasmodium falciparum. J. Antibiot., 64, 381-384 (2011).

1094) S. Ohte, D. Matsuda, R. Uchida, K. Nonaka, R. Masuma, S. Ōmura, and H. Tomoda: Dinapinones, novel inhibitors of triacylglycerol synthesis in mammalian cells, produced by Penicillium pinophilum FKI-3864. J. Antibiot., 64, 489-494 (2011).

1095) A. Takahashi, J. Inokoshi, A. Hachiya, S. Oka, S. Ōmura, and H. Tanaka: The high mannose-type glycan binding lectin actinohivin: dimerization greatly improves anti-HIV activity. J.Antibiot., 64, 551-557 (2011).

1096) H. Oguri, T. Hiruma, Y. Yamagishi, H. Oikawa, A. Ishiyama, K. Otoguro, H. Yamada, and S. Ōmura: Generation of anti-trypanosomal agents through concise synthesis and structural diversification of sesquiterpene analogues. J. Am. Chem. Soc., 133, 7096-7105 (2011).

1097) K. Otoguro, M. Iwatsuki, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, H. Kiyohara, T. Hashimoto, Y. Asakawa, S. Ōmura, and H. Yamada: In vitro antitrypanosomal activity of plant terpens against Trypanosoma brucei. Phytochemistry, 72, 2024-2030 (2011).

1098) S. Kitani, K. T. Miyamoto, S. Takamatsu, E. Herawati, H. Iguchi, K. Nishitomi, M. Uchida, T. Nagamitsu, S. Ōmura, H. Ikeda, and T. Nihira: Avenolide, a Streptomyces hormone controlling antibiotic production in  Streptomyces avermitilis. Proc. Natl. Acad. Sci., USA, 108, 16410-16415 (2011).

1099) A. Sugawara, A. Sueki, T. Hirose, K. Nagai, H. Gouda, S. Hirono, H. Shima, K. S. Akagawa, S. Ōmura, and T. Sunazuka: Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel lead for anti-inflammatory and/or immunomodulatory agents. Bioorg, & Med. Chem. Lett., 21, 3373-3376 (2011).

1100) T. Miyagawa, K. Nagai, A. Yamada, Y. Sugihara, T. Fukuda, R. Uchida, H. Tomoda, S. Ōmura, and T. Nagamitsu: Total synthesis of citridone A. Org. Lett., 13, 1158-1161 (2011).

1101) H. Matsui, H. Hanaki, M. Inoue, H. Akama, T. Nakae, K. Sunagawa, and S. Ōmura: Development of an immiunochromatographic strip for simple detection of Penicillin-binding protein 2’∇. Clin. Vacc. Immunol., 18, 248-253 (2011).

1102) K. Nonaka, R. Masuma, M. Iwatsuki, K. Shiomi, K. Otoguro, and S. Ōmura: Penicillium viticola, a new species isolated from a grape in Japan. Mycoscience 52, 338-343 (2011).

1103) T. Ohshiro, D. Matsuda, K. Sasaki, C. Degirolamo, Hiroaki Yagyu, L. L. Rudel, S. Ōmura, S. Ishibashi, H. Tomoda: Pyripyropene A, an acyl-coenzyme A: cholesterol acyltransferase 2-selective  inhibitor, attenuates hyperchol- esterolemia and atherosclerosis in murine models  of hyperlipidemia. Arterioscler. Thromb. Vasc. Biol., 3, 1108-1115 (2011).

1104) S. Ōmura: Microbial metabolites: 45 years of wandering, wondering and discovering. Tetrahedron, 67, 6420-6459 (2011).

1105) T. Shirahata, A. Kojima, S. Teruya, J. Matuo, M. Yokoyama, S. Unagiike, T. Sunazuka, K. Makino, E. Kaji, S. Ōmura, and Y. Kobayashi: Sequential one-pot glycosylation with glycosyl N-trichloroacetylcarbamate and trichloroacetate including dehydrative approach using 1-hydroxy sugars. Tetrahedron, 67, 6482-6496 (2011).

1106) M. Mori, H. Morimoto, Y.-P. Kim, H. Ui, K. Nonaka, R. Masuma, K. Sakamoto, K. Kita, H. Tomoda, K. Shiomi, and S. Ōmura: Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp. FKI-3389. Tetrahedron, 67, 6582-6586 (2011).

1107) T. Hirose, T. Kasai, T. Akimoto, A. Emndo, A. Sugawara, K. Nagasawa, K. Shiomi, S. Ōmura, T. Sunazuka: Solution-phase total synthesis of the hydrophilic natural product argifin using 3,4,5-tris(octadecycloxy)benzyl tag. Tetrahedron, 67, 6633-6643 (2011).

1108) M. Iwatsuki, T. Ishimori, T. Yamamoto, K. Takata, M Mori, K. Nonaka, R. Masuma, Y. Hayakawa, H. Hanaki, K. Shomi, and S. Ōmura: Biverlactones A-D, new circumventors of arbekacin resistance in MRSA, produced by Penicillium sp. FKI-4429. Tetrahedron, 67, 6644-6648 (2011).

1109) T. Hirose, M. Iwatsuki, S. Ōmura, and T. Sunazuka: Isolation, total synthesis and determination of the absolute configuration of guadinomines: potent inhibitors of a bacterial type III secretion system (Rev. article). Journal of Synthetic Organic Chemistry, Japan, 69, 775-788 (2011).

1110) A. Odani, K. Ishihara, M. Ohtawa, H. Tomoda, S. Ōmura, and T. Nagamitsu: Total synthesis of pyripyropepe A. Tetrahedron, 67, 8195-8203 (2011).

1111) K. Nonaka, T. Abe, M. Iwatsuki, M. Mori, T. Yamamoto, K. Shiomi, S. Ōmura, and R. Masuma: Enhancement of metabolites productivity of Penicillium FKI-5653, by co-culture with Trichoderma harzianum FKI-5655. J. Antibiot., 64, 769-774 (2011).

1112) A. Matsumoto, A. Fukuda, Y. Inahashi, S. Ōmura, and Y. Takahashi: Actinoallomurus radicium sp. nov., isolated from the roots of two plant species. Int. J. Syst. Evol. Microbiol., 62, 295-298 (2012).

1113) N. Ugaki, D. Matsuda, H. Yamazaki, K. Nonaka, R. Masuma, S. Ōmura, and H. Tomoda. J. Antibiot., 65, 15-19 (2012).

1114) A. Ishiyama, K. Otoguro, M. Iwatsuki, M. Namatame, A. Nishihara-Tsukashima, Y. Takahashi, H. Onodera, H. Yamada, and S. Ōmura: In vitro antitrypanosomal activity of five low-MW antibiotics. J. Antibiot., 65, 113-114 (2012).

1115) K. Otoguro, A. Ishiyama, M. Iwatsuki, M. Namatame, A. Nishihara-Tsukashima, H. Kiyohara, T. Hashimoto, Y. Asakawa, S. Ōmura, and H. Yamada: In vitro antitrypanosomal activity of　bis(bibenzyls)s and bibenzyls from liverworts against Trypanosoma brucei. J. Nat. Med., 55, 377-382 (2012).

1116) T. Ishii, K. Nonaka, M. Iwatsuki, R. Masuma, S. Ōmura, and K. Shiomi: Virgaricin produced by Virgaria sp. FKI-4860. J. Antibiot., 65, 139-141 (2012).

1117) M. Iwatsuki, A. Nishihara-Tsukashima, A. Ishiyama, M. Namatame, Y. Watanabe, S. Handasah, H. Pranamuda, B. Marwoto, A. Matsumoto, Y. Takahashi, K. Otoguro, and S. Ōmura: Jogyamycin, a new antiprotozoal aminocyclopentitol antibiotic, produced by Streptomyces sp. a-WM-JG-16.2. J. Antibiot., 65, 169-171 (2012).

1118) J. Hashida, M. Niitsuma, M. Iwatsuki, M. Mori, A. Ishiyama, M. Namatame, A. Nishihara-Tsukashima, A. Matsumoto, I. Ara, Y. Takahashi, H. Yamada, K. Otoguro, K. Shiomi, and S. Ōmura: Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp. K07-0010. J. Antibiot., 65, 197-201 (2012).

1119) R. Koyama, A. Matsumoto, Y. Inahashi, S. Ōmura, and Y. Takahashi: Isolation of actinomycetes from the root of the plant, Ophiopogon japonicus, and proposal of two new species, Actinoallomurus liliacearum sp. nov. and Actinoallomurus vinaceus sp. nov. J. Antibiot., 65, 335-340 (2012).

1120) H. Gouda, Y. Kobayashi, T. Yamada, T. Ideguchi, A. Sugawara, T. Hirose, S. Ōmura, T. Sunazuka, and S. Hirono: Three-dimensional solution structure of bottromycin A2: a potent antibiotic active against meticillin-resistant Staphylococcus aureus and vancomycin-resistant Enteroocci. Chem. Pharm. Bull., 60, 169-171 (2012).

1121) M. Ohtawa, K. Sugiyama, T. Hiura, S. Izawa, K. Shiomi, S. Ōmura, and T. Nagamitsu: Stereoselective total synthesis of atpenins A4 and B, harzianopyridone, and NBRI23477B. Chem. Pharm. Bull., 60, 898-906 (2012).

1122) K. Nonaka, H. Miyazaki, M. Iwatsuki, K. Shiomi, H. Tomoda, S. Ōmura, and R. Masuma: Staphylotrichum boninense, a new hyphomycete (Chaetomiaceae) from soils in the Bonin Island, Japan. Mycoscience, 53, 312-318 (2012).

1123) T. Nakashima, S. Ōmura, and Y. Takahashi: Generation of superoxide anions by a glycation reaction in conventional laboratory media. J. Biosci. Bioeng., 114, 275-280 (2012).

1124) A. Crump, C. M. Morel, and S. Ōmura: The onchocerciasis chronicle: from the beginning to the end? Trends in Parasitology, 28, 280-288 (2012).

1125) T. Yamamoto, N. Izumi, H. Ui, A. Sueki, R. Masuma, K. Nonaka, T. Hirose, T. Sunazuka, T. Nagai, H. Yamada, S. Ōmura, and K. Shiomi: Wickerols A and B: novel anti-influenza virus diterpenes produced by Trichoderma atroviride FKI-3849. Tetrahedron, 68, 9267-9271 (2012).

1126) T. Suga, T. Ishii, M. Iwatsuki, T. Yamamoto, K. Nonaka, R. Masuma, H. Matsui, H. Hanaki, S. Ōmura, and K. Shiomi: Aranorosin circumvents arbekacin-resistant in MRSA by inhibiting the bifunctional enzyme AAC (6’)/APH(2”). J. Antibiot., 65, 527-529 (2012).

1127) Y. Noguchi, T. Hirose, Y. Furuya, A. Ishiyama, K. Otoguro, S. Ōmura, and T. Sunazuka: The first total synthesis and reassignment of the relative stereochemistry of     16-hydroxy- 16,22-dihydroapparicine. Tetrahedron Lett., 53, 1802-1807 (2012).

1128) A. Kimishima, T. Hirose, A. Sugawara, T. Matsumaru, K. Nakamura, K. Katsuyama, M. Toda, H. Takada, R Masuma, S. Ōmura, and T. Sunazuka: Toward the total synthesis of luminamicin: construction of 14-membered lactone framework possessing versatile enol ether moiety. Tetrahedron Lett., 53, 2813-2816 (2012).

1129) S. Kaifuchi, K. Nonaka, M. Mori, K. Shiomi, S. Ōmura, and R. Masuma: Inducing pigmentation using Hypocrea/Trichoderma co-cultures. Jpn. J. Mycology, 53, 71-81 (2012).

1130) T. Seki, A. Matsumoto, R. Shimada, Y. Inahashi, S. Ōmura, and Y. Takahashi: Conexibacter arvalis sp. nov., isolated from a cultivated field solid sample. Int. J. System. Evol. Microbiol., 62, 2400-2404 (2012).

1131) Y. Inahashi, A. Matsumoto, S. Ōmura, and Y. Takahashi: Phytohabitans flavus sp. nov., Phytohabitans rumicis sp. nov. and Phytohabitans houttuyneae sp. nov., isolated from plant roots, and emended description of the genus Phytohabitans. Int. J. System. Evol. Microbiol., 62, 2717-2723 (2012).

1132) T. C. Holmes, A. E. May, K. Zaleta-Rivera, J. Graham Ruby, P. Skewes-Cox, M. A. Fischbach, J. I. DeRisi, M. Iwatsuki, S. Ōmura, and A. Khosla:Molecular insights into the biosynthesis of guadinomine: A type III secretion system inhibitor. J. Am. Chem. Soc., 123, 17797-17806 (2012).

1133) M. Mominul Hoque, K. Suzuki, M. Tsunoda, J.Iiang, F. Zhang, A. Taahashi, N. Ohbayashi, X. Zhang, H. Tanaka, S. Ōmura, and A. Takenaka: Structural insights into the specific anti-HIV property of actinohivin: structure of its complex with the a(1-2)mannobiose moietuy of gP120. Acta Cryst., D68, 1671-1679 (2012).

1134) A. Sugawara, A. Sueki, H. Hirose, H. Shima, K. S. Akagawa, S. Ōmura, and T. Sunazuka:　Novel 12-membered non-antibiotic macrolides, EM900 series with anti-inframmatory and/or immuno- modulatory activity: synthesis, strucutre-activity relationships and in vivo study. J. Antibiot., 65, 487-490 (2012).

1135) T. Suzuki, J-H. Choi, T. Kawaguchi, K. Yamashita, A. Morita, H. Hirai, K. Nagai, T. Hirose, S. Ōmura, T. Sunazuka, and H. Kawagishi: Makomotindoline from Makomotake, Zizania latifolia infected with Ustilago esculenta. Bioorg. Med. Chem. Lett., 22, 4246-4248 (2012).

1136) M. R. Fullone, A. Paiardini, R. Miele, S. Marsango, D. C. Gross, S. Ōmura, E. R.-Herrera, M. C. B. di Patti, A. Lagana, S. Pascarella, and I. Grgurina: Insight into the structure-function relationship of the nonheme iron halogenases involved in the biosynthesis of 4-chlorothreonine-Thr3 from Streptomyces sp. OH-5093 and SyrB2 from Pseudomonas syringae pv. syringae B301DR. FEBS J., 279, 4269-4282 (2012).

1137) H. Oguri, H. Mizoguchi, H. Oikawa, A. Ishiyama, M. Iwatsuki, K. Otoguro, and S. Ōmura: Parallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization. Beilstein J. Org. Chem., 8, 930-940 (2012).

1138) M. Ohtawa, H. Yamazaki, S. Ohte, D. Matsuda, T. Ohshiro, L. L. Rudel, S. Ōmura, H. Tomoda, and T. Nagamitsu: Synthesis and struture-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 1. Bioorg. Med. Chem. Lett., 23, 1285-1287 (2013).

1139) K. Nonaka, S. Kaifuchi, S. Ōmura, and R. Masuma: Five new Simplicillium species (Cordycipitaceae) from soils in Tokyo, Japan. Mycoscience, 54, 42- 53 (2013).

1140) S. Kaifuchi, K. Nonaka, M. Mori, K. Shiomi, S. Ōmura, and R. Masuma: Lecanicillium primulinum,　a new hyphomycete (Cordycipitaceae) from soils in the okinawa’s main island and the Bonin Islands, Japan. Mycoscience, 54, 291-296 (2013).

1141) A. Tsutsui, T. Hirose, A. Ishiyama, M. Iwatsuki, A. Yokota, H. Maruyama, H. Matsui, K. Otoguro, H. Hanaki, S. Ōmura, and T. Sunazuka: Antimalarial C-9 oxime derivatives from desmycosin, produced by click chemistry. J. Antibiot., 66, 191-194 (2013).

1142) T. Nakashima, R. Okuyama, Y. Kamiya, A. Matsumoto, M. Iwatsuki, Y. Inahanashi, K. Yamaji, Y. Takahashi, and S. Ōmura: Trehangelins A, B and C, novel photo-oxidative hemolysis inhibitors produced by an endophytic actinomycete, Polymorphospora rubra K07-0510. J. Antibiot., 66, 311-317 (2013).

1143) K. Nonaka, T. Ishii, K. Shiomi, S. Ōmura, and R. Masuma: Virgaria boninensis, a new hyphomycete (Xylariaceae) from soils in the Bonin Island, Japan. Mycoscience, 54, 394-399 (2013).

1144) H. Miura, K. Hori, Y. Sasaki, Y. Inahashi, Y. Yagisawa, N. Fujita, S. Ōmura, and Y. Takahashi: Simple analytic method of diamino-pimelate epimerase activity. J. Biosci. Bioeng., 116, 253-255 (2013).

1145) T. Ishii, K. Nonaka, T. Suga, R. Masuma, S. Ōmura, and K. Shiomi: Cytosporone S with antimicrobial activity, isolated from the fungus Trichoderma sp. FKI-6626. Bioorg. Med. Chem. Lett., 23, 679-681 (2013).

1146) A. Sugawara, T. Tanaka, T. Hirose, A. Ishiyama, M. Iwatsuki, Y. Takahashi, K. Otoguro, S. Ōmura, and T. Sunazuka: Borrelidin analogues with antimalarial activity: Design, synthesis and biological evaluation against Plasmodium falciparum parasites. Bioorg. Med. Chem. Lett., 23, 2302-2305 (2013).

1147) M. Ohtawa, H. Yamazaki, D. Matsuda, T. Ohshiro, L. L. Rudel, S. Ōmura, H. Tomoda, and T. Nagamitsu: Synthesis and structure-activity relationship of pyripyropene A derivatives and potent and selective acyl-CoA:cholesterol acyl-transferase 2 (ACAT2) inhibitors: part 2. Bioorg. Med. Chem. Lett., 23, 2659-2662 (2013).

1148) M. Ohtawa, H. Yamazaki, S. Ohte, D. Matsuda, T. Ohshiro, L. L. Rudel, S. Ōmura, H. Tomoda, and T. Nagamitsu: Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 3. Bioorg. Med. Chem. Lett., 23, 3798-3801 (2013).

1149) K. Nonaka, S. Ōmura, R. Masuma, and S. Kaifuchi: Three new Pochonia taxa (Clavicipitaceae) from soils in Japan. Mycologia, 105, 1202-1218 (2013).

1150) T. Hirose, Y. Noguchi, Y. Furuya, A. Ishiyama, M. Iwatsuki, K. Otoguro, S. Ōmura, and T. Sunazuka: Structure determination and total synthesis (+)-16-hydroxy-16,22-dihydro-apparicine. Chem. Eur. J., 19, 10741-10750 (2013).

1151) M. Komatsu, K. Komatsu, H. Koiwai, Y. Yamada, I. Kozone, M. Izumikawa, J. Hashimoto, M. Takagi, S. Ōmura, K. Shin-ya, D. E. Cane, and H. Ikeda: Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites. ACS Synth. Biol., 2, 384-396 (2013).

1152) B. Intra, A. Matsumoto, Y. Inahashi, S. Ōmura, Y. Takahashi, and W. Panbangred: Actino- kineospora bangkokensis sp. nov., isolated from rhizospheric soil. Int. J. System. Evol. Microbiol., 63, 2655-2660 (2013).

1153) A. Matsumoto, H. Kasai, Y. Matsuo, Y. Shizuri, N. Ichikawa, N. Fujita, S. Ōmura, and Y. Takahashi: Ilumatobacter nonamiense sp. nov. and Ilumatobacter coccineum sp. nov., isolated from seashore sand. Int. J. System. Evol. Microbiol., 63, 3404-3408 (2013).

1154) Y.-J. Li, T. Shimizu, Y. Hirata, H. Inagaki, H. Takizawa, A. Azuma, T. Kawada, I. Sugawara, S. Kudoh, T. Sunazuka, and S. Ōmura: EM, EM703 inhibit NF-kB activation induced by oxidative stress from diesel exhaust particle in human bronchial epithelial cells: importance in IL-8 transcription. Pulm. Pharmacol. Ther., 26, 318-324 (2013).

1155) M. Wakasugi, H. Gouda, T. Hirose, A. Sugawara, T. Yamamoto, K. Shiomi, T. Sunazuka, S. Ōmura, and S. Hirono: Human acidic mammalian chitinase as a novel target for anti-asthma drug design using in silico screening. Bioorg Med. Chem., 21, 3214-3220 (2013).

1156) T. Ideguchi, T. Yamada, T. Shirahata, T. Hirose, A. Sugawara, Y. Kobayashi, S. Ōmura, and T. Sunazuka: Asymmetric total synthesis of neoxaline. J. Am. Chem. Soc., 135, 12568-12571 (2013).

1157) T. Hirose, N. Maita, H. Gouda, J. Koseki, T. Yamamoto, A. Sugawara, H. Nakano, S. Hirono, K. Shiomi, T. Watanabe, H. Taniguchi, K. B. Sharpless, S. Ōmura, and T. Sunazuka: Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor. Proc. Natl. Acad. Sci., USA, 110, 15892- 15897 (2013).

1158) K. Takata, M. Iwatsuki, T. Yamamoto, T. Shirahata, K. Nonaka, R. Masuma,Y. Hayakawa, H. Hanaki, Y. Kobayashi, G. A. Petersson, S. Ōmura, and K. Shiomi: Aogacillins A and B produced by Simplicillium sp. FKI-5985: New circumventors of arbekacin resistance in MRSA. Org. Lett., 15, 4678-4681 (2013).

1159) Y. Aoyagi, K. Fujiwara, A. Yamazaki, N. Sugawara, R. Yano, H. Fukaya, Y. Hitotsuyanagi, K. Takeya, A. Ishiyama, M. Iwatsuki, K. Otoguro, H. Yamada, S. Ōmura: Semisynthesis of salviandulin E analogues and their antitrypanosomal activity. Bioorg. Med. Chem. Lett., 24, 442-446 (2014).

1160) A. Umeyama, K. Takahashi, A. Grundniewska, M. Shimizu, S. Hayashi, M. Kato, Y. Okamoto, M. Suenaga, S. Ban, T. Kumada, A. Ishiyama, M. Iwatsuki, K. Otoguro, S. Ōmura, and T. Hashimoto: In vitro antitrypanosomal activity of the cyclodepsipeptides, cardinalisamides A-C, from the insect  pathogenic fungus Cordyceps cardinalis NBRC 103832.  J. Antibiot., 67, 163-166 (2014).

1161) H. Ikeda, K. Shin-ya, S. Ōmura: Genome mining of the Streptomyces avermitilis genome and development of genome minimized hosts for heterologous expression of biosynthetic gene clusters (Review article). J. Ind. Microbiol. Biotechnol., 42, 233-250 (2014).

1162) R. Sugamata, A. Sugawara, T. Nagao, K. Suzuki, T. Hirose, K. Yamamoto, M. Oshima, J, Kobayashi, T. Sunazuka, K. S. Akagawa, S. Ōmura, T. Nakayama, and K. Suzuki: Leucomycin A3, a 16-membered macrolide antibiotic, inhibits influenza A virus infection and disease progression. J. Antibiot., 67, 213-222 (2014).

1163) T. Nakashima, M. Iwatsuki, J. Ochiai, Y. Kamiya, K. Nagai, A. Matsumoto, A. Ishiyama, K. Otoguro. K. Shiomi, Y. Takahashi, and S. Ōmura: Mangromicins A and B: structure and antitrypanosomal activity of two new cyclopentadecane compounds from Lechevalieria aerocolonigenes K10-0216. J. Antibiot., 67, 253-260 (2014).

1164) A. Ishiyama, M. Iwatsuki, T. Yamamoto, H. Miura, S. Ōmura, and K. Otoguro: Antimalarial tropones and their Plasmodium falciparum glyoxalase I (pfGLO1) inhibitory activity. J. Antibiot., 67, 545-547 (2014).

1165) B. Intra, A. Matsumoto, Y. Inahashi, S. Ōmura, W. Panbangred, and Y. Takahashi: Streptosporangium jomthongense sp. nov., an actinomycetes isolated from rhizosperic soil and emendation of the genus Streptosporangium. Int. J. System. Evol. Microbiol., 64, 2400-2406 (2014).

1166) T. Nakashima, Y. Kamiya, M. Iwatsuki, Y. Takahashi, and S. Ōmura: Mangromicins, six new anti-oxidative agents isolated from a culture borth of the actinomycete, Lechevalieria aerocolonigenes K10-0216. J. Antibiot., 67, 533-539 (2014).

1167) S. Sakuda, D. F. Orabowo, K. Takagi, K. Shiomi, M. Mori, S. Ōmura, and H. Nagasawa: Inhibitory effects of respiration inhibitors on aflatoxin production. Toxin, 6, 1193-1200 (2014).

1168) G. Sennari, T. Hirose, M. Iwatsuki, S. Ōmura, and T. Sunazuka: A concise total synthesis of puberulic acid, a potent antimalarial agent. Chem. Commun., 50, 8715-8718 (2014).

1169) S. Hayashi, T. Ozaki, S. Asamizu, H. Ikeda, S. Ōmura, N. Oku, Y. Igarashi, H. Tomoda, and H. Onaka: Genome mining reveals a minimum gene set for the biosynthesis of 32-membered macrocyclic thiopeptides lactazoles. Chem. Biol., 21, 679-688 (2014).

1170)  A. Matsumoto, Y. Kawaguchi, T. Nakashima, M. Iwatsuki, S. Ōmura, and Y. Takahashi: Rhizocola hellebori gen. nov., sp. nov., an actinomycete of the family Micromonosporaceae containing 3,4- dihydroxy-diaminopimelic acid in the cell-wall peptidoglycan. Int. J. System. Evol. Microbiol., 64, 2706-2711 (2014).

1171)  A. Umeyama, C. Ohta, Y. Shino, M. Okada, Y. Nakamura, T. Hamagaki, H. Imagawa, M. Tanaka, A. Ishiyama, M. Iwatsuki, K. Otoguro, S. Ōmura, and T. Hashimoto: Three lanostane triterpenoids with anti- trypanosomal activity from the fruiting body of Hexagonia tenuis. Tetrahedron, 70, 8312-8315 (2014).

1172) S. Ōmura and A. Crump: Ivermectin: panacea for resource-poor communities? (Review article). Trends Parasitol., 30, 445-455 (2014).

1173) K. Nonaka, N. Todaka, S. Ōmura, and R. Masuma: Combination cellulose plate (non-agar solid support) and agar plate method improves isolation of fungi from soil. J. Antibiot., 67, 755-761 (2014).

1174) H. Miura, Y. Yagisawa, Y. Kato, K. Hayashi, N. Fujita, S. Ōmura, and Y. Takahashi: Transcriptional analysis of genes encoding proteins significantly increased in Kitasatospora setae KM-6054T under submerged culture. J. Gen. Appl. Microbiol., 60, 276-280 (2014).